Search Results - life+sciences+%3e+research+tools

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High-throughput detection of single nucleotide polymorphisms (SNPs) via CRISPR-based diagnostic platform
This CRISPR-based technology enables precise detection of single nucleotide polymorphisms (SNPs) in nucleic acids by using programmed mismatches between CRISPR RNA and target nucleic acids, facilitating high-throughput, quantitative, and point-of-care diagnostics. Background Single nucleotide polymorphisms (SNPs) play a crucial role in disease susceptibility,...
Published: 10/21/2024   |   Inventor(s): Ilya Finkelstein, Hung-Che Kuo, Chia-Wei Chou
Keywords(s):  
Category(s): Life sciences > Diagnostic, Life sciences > Research tools
High-speed laser scanning and microfluidic device system for automated 3D imaging and specimen manipulation
The high-speed laser scanning microscopy platform enables rapid, automated 3D imaging of biological specimens, offering flexible control over imaging parameters, large field-of-view, and high-resolution imaging, ideal for studying dynamic processes in living organisms. Background Laser scanning systems, particularly in the field of microscopy, have...
Published: 10/4/2024   |   Inventor(s): Adela Ben-Yakar, Ki Hyun Kim, Evan Hegarty, Sertan Gokce, Sudip Mondal
Keywords(s):  
Category(s): Life sciences > Imaging, Life sciences > Research tools
Human enzyme-mediated depletion of serine in cancer
Engineered human serine dehydratase enzymes are designed to efficiently degrade serine, an amino acid crucial to cancer cell metabolism, and inhibit cancer growth. These enzymes, with improved stability, activity, and bio­availability, offer a targeted cancer treatment option with fewer adverse effects. Background Traditional chemotherapeutic...
Published: 8/29/2024   |   Inventor(s): Everett Stone, Ebru Cayir, Daniel Diaz, Raghav Shroff
Keywords(s):  
Category(s): Life sciences > Therapeutics > Small molecule, Life sciences > Research tools
Engineered sugar uptake in yeast cells
The technology focuses on engineered transporter proteins that enhance the uptake of specific monosaccharides like xylose and arabinose into yeast cells, improving their efficiency and selectivity for biofuel and biochemical production. Background The efficient conversion of lignocellulosic biomass into biofuels and bio­chemicals is a critical...
Published: 8/15/2024   |   Inventor(s): Hal Alper, Eric Young
Keywords(s):  
Category(s): Life sciences > Metabolic engineering, Life sciences > Research tools, Physical sciences > Energy > Renewable
RealCooL: rapid thermal control of liquids
Problem statement Current technologies to heat or cool liquids, such as water baths to rewarm or pasteurize human milk, suffer from slow heating times and inability to control temperature accurately. There is a need for a device that is faster, more accurate, and safer for babies and caregivers to use. Solution RealCooL was developed by engineers...
Published: 6/25/2024   |   Inventor(s): Marissa Rylander, Christopher Rylander
Keywords(s):  
Category(s): Life sciences > Research tools, Life sciences > Medical technology > Medical devices
Degradons: target proteins for degradation without ubiquitination
Problem Targeting specific proteins for degradation is an area of intense research for the treatment of disease. The majority of currently available technologies, such as PROTACs, induce degradation through ubiquitination of target proteins by binding to both the target protein and ubiquitin ligases. However, this requires a ubiquitin ligase to efficiently...
Published: 11/5/2024   |   Inventor(s): Andreas Matouschek
Keywords(s):  
Category(s): Life sciences > Research tools, Life sciences > Metabolic engineering