Search Results - andreas+matouschek

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Modular protein degradation platform bypassing ubiquitination
Background Targeted protein degradation is rapidly emerging as a powerful therapeutic approach for eliminating disease-causing proteins in cancer, neuro­degenera­tive conditions, autoimmune disorders, and viral infections. By removing, rather than inhibiting, harmful proteins, this strategy enables direct and sustained therapeutic effects....
Published: 7/31/2025   |   Inventor(s): Andreas Matouschek, Amit Kumar Singh Gautam, Caroline Davis, Logan Spaller
Keywords(s):  
Category(s): Life sciences > Therapeutics > Synthetic biology, Life sciences > Research tools > Tool/assay/screening platform
Degradons: target proteins for degradation without ubiquitination
Problem Targeting specific proteins for degradation is an area of intense research for the treatment of disease. The majority of currently available technologies, such as PROTACs, induce degradation through ubiquitination of target proteins by binding to both the target protein and ubiquitin ligases. However, this requires a ubiquitin ligase to efficiently...
Published: 7/14/2025   |   Inventor(s): Andreas Matouschek
Keywords(s):  
Category(s): Life sciences > Research tools, Life sciences > Metabolic engineering