Search Results - vandana+kumari

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Star, Branched, and Graft Polymers in Binders for Inkjet Additive Manufacturing for Personalized Dosage Tablets
THE CHALLENGE A major problem posed by the pharmaceutical industry is giving effective dosages while not giving excessive amounts of a particular drug. An estimated 80% of side effects in humans and animals are a direct result of inaccurate dosing because varying weights in patients. Additive manufacturing has emerged as a very promising method to...
Published: 1/31/2024   |   Inventor(s): Emily Wilts, Timothy Long, Christopher Williams, Da Ma
Keywords(s):  
Category(s): Technology Classifications > Additive Manufacturing, Technology Classifications > Biomedical, Technology Classifications > Chemicals/Materials, Technology Classifications > Pharmacology and Therapeutics
PARP Inhibitor and NO-Donor Dual Prodrugs as Anticancer Agents
Abstract: Poly-ADP ribose polymerase-1 (PARP-1) is a critical enzyme involved in DNA repair.  The inhibition of PARP has emerged as a promising strategy in cancer therapy.  Numerous PARP inhibitors have been developed and advanced into clinical trials, both for use as single agents in specific patient populations and as combination therapies with various...
Published: 5/22/2024   |   Inventor(s): Anna Maciag, Joseph Saavedra, Larry Keefer, Xinhua Ji, Vandana Kumari
Keywords(s): nitric oxide, PARP, poly-ADP-ribose polymerase, prodrug
Category(s): TherapeuticArea > Oncology, Application > Therapeutics, Collaboration Sought > Licensing