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First in class Small Molecule Agonists of the mammalian Relaxin family receptor 1 (RXFP1) and use in treatment of cancer, fibrotic, and vascular disorders (HHS Ref No. E-145-2024-0-US-02)

It is well documented in literature that activation of RXFP1 by relaxin induces: 1) up-regulation of the endothelin system which leads to vasodilation; 2) extracellular matrix remodeling through regulation of collagen deposition, cell invasiveness, proliferation, and overall tissue homeostasis; 3) a moderation of inflammation by reducing levels of inflammatory...

Published: 5/30/2025 | Inventor(s): Juan Marugan, Mark Henderson, Kenneth Wilson, Wenwei Huang, Wenjuan Ye, Noel Southall, Jiankang Jiang, Khalida Shamim, Bing Li, Alexander Agoulnik, Abhijeet Kapoor, Joshua Hutcheson, Ana Cabrera, Irina Agoulnik

Keywords(s):

Category(s): Application > Therapeutics, Application > Research Materials, TherapeuticArea > Oncology, TherapeuticArea > Cardiology, TherapeuticArea > Pulmonology, TherapeuticArea > Dermatology, TherapeuticArea > Reproductive Health, TherapeuticArea > Geriatrics

Visualization of Individual Coagulation Profiles

Undetected variations in an individual’s global hemostasis are risk factors for cardiovascular and neurovascular disease both in therapeutic treatment and in “normal” situations such as pregnancy and aging. Professor Brummel-Ziedins and her team have developed algorithms to support clinical visualization of individual patient hemostatic...

Published: 5/21/2025 | Inventor(s): Kathleen Brummel-Ziedins, Christopher Danforth, Kenneth Mann, Thomas Orfeo, Stephen Everse

Keywords(s):

Category(s): Technology Classifications > Biomedical

Next-Generation 5-HT-2B Serotonin-Receptor Antagonists for Anti-Fibrotic & Cardiopulmonary Therapy

This technology includes a family of small-molecule antagonists that selectively block the 5-HT2B serotonin receptor—an upstream driver of tissue-remodeling—to address fibrotic, cardiopulmonary and related disorders. Built on a conformationally-locked “(N)-methanocarba” nucleoside scaffold, the compounds show nanomolar potency,...

Published: 5/14/2025 | Inventor(s): Kenneth Jacobson, Dilip Tosh

Keywords(s):

Category(s): Application > Research Materials, Application > Therapeutics, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Cardiology, TherapeuticArea > Dermatology, TherapeuticArea > Immunology, TherapeuticArea > Metabolic Disease, TherapeuticArea > Oncology, TherapeuticArea > Pulmonology, TherapeuticArea > Respiratory

RNA Purification with DNA Nanoswitches

Novel, user-centric technology for detecting and analyzing RNA that accelerates the pace of discovery in RNA research. Background: RNA purification is an important part of biomedical research, and very few tools exist for pulling specific RNAs out of a complex solution. Further, understanding of RNA and its complex roles in biology is constantly evolving....

Published: 5/13/2025 | Inventor(s): Kenneth Halvorsen, Lifeng Zhou

Keywords(s):

Category(s): Campus > University at Albany, Technology Classifications > Diagnostics, Technology Classifications > Research Tools and Reagents

Portable Assay for COVID-19 Diagnostic

A low-cost, rapid, and more accurate gel electrophoresis-based assay using DNA nanoswitches for detecting COVID-19 and other viruses. Background: Viral diagnostics are of prime importance for testing infection rates and for timely treatment, especially in the case of a pandemic such as the current COVID-19 outbreak caused by the SARS-CoV-2 corona...

Published: 5/13/2025 | Inventor(s): Kenneth Halvorsen, Lifeng Zhou

Keywords(s): DNA, RNA, Technologies

Category(s): Campus > University at Albany, Technology Classifications > Diagnostics

Ribonuclease-responsive DNA Nanoswitches

A DNA nanoswitch that provides a simple mix-and-read methodology to detect RNases (ribonucleases) in a biological sample. Background: RNases are involved in many biological processes including neurotoxicity, genome replication and maintenance, immune-suppression, and antitumor activity. RNase inhibitors are also potential drug candidates and biomarkers...

Published: 5/13/2025 | Inventor(s): Kenneth Halvorsen, Arun Richard Chandrasekaran

Keywords(s): DNA, RNA, RNA-switch

Category(s): Campus > University at Albany, Technology Classifications, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Research Tools and Reagents, Technology Classifications > Diagnostics

Zika Virus Vaccine

A killed ZIKA vaccine that prevents infection and is safe for pregnant women. Background: Zika virus (ZIKV) is a Flavivirus transmitted by mosquitoes. First discovered in 1947, it remained a minor infectious entity until 2007, when the first large outbreak was reported in Micronesia. Subsequent severe outbreaks in French Polynesia (2013-14)...

Published: 5/13/2025 | Inventor(s): Timothy Endy, Kenneth Eckels

Keywords(s): Technologies, vaccines

Category(s): Campus > Upstate Medical University, Technology Classifications > Therapeutics and Vaccines

Design and Use of Multi-targeting DNA Nanoswitches for Increased Sensitivity Detection of Long RNAs

This technology provides a novel method for detecting COVID-19 and potentially other virus-based diseases. Background: The COVID-19 pandemic created an unprecedented need for large scale diagnostic testing. Unfortunately, the pandemic also created a number of challenges for traditional in vitro diagnostic techniques. These challenges include reagent...

Published: 5/13/2025 | Inventor(s): Kenneth Halvorsen

Keywords(s): detection, DNA nanoswitches, Sensitivity, Technologies

Category(s): Campus > University at Albany, Technology Classifications, Technology Classifications > Diagnostics, Technology Classifications > Research Tools and Reagents

Ophthalmoscopic Device and Method for Capturing Images using the Same

The invention is a low-cost, portable in-vivo confocal ophthalmoscope (PICO) designed to capture microscopic images of the anterior segment of the eye and external eye structures without direct contact. The device is compact, lightweight, and capable of providing high-resolution imaging for real-time diagnostics. This ophthalmoscope can attach to standard...

Published: 4/14/2025 | Inventor(s): Dongkyun Kang, Kenneth Marcelino, Momoka Sugimura, Jaya Chidambaram

Keywords(s):

Category(s): Technology Classifications > Imaging & Optics > Lens & System Design, Technology Classifications > Medical Devices > Diagnostic, Technology Classifications > Imaging & Optics > Ophthalmology, Technology Classifications > Healthcare Portfolios > Ophthalmology

Flexible heat exchange system for maintaining patient core body temperature during medical procedures

A flexible, self-regulating heat exchange pad maintains patients’ body temperature during medical procedures. Adhesive, conforming pads with built-in heaters ensure even heat distribution, prevent overheating, and avoid pressure sores without mechanical restraints. Background Maintaining patients’ core body temperature during medical...

Published: 3/3/2025 | Inventor(s): Kenneth Diller, Sepideh Khoshnevis, Brian Patrick, Patrick Brown

Keywords(s):

Category(s): Life sciences > Medical technology

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