Search Results - kenneth+margulies

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Mechanically Tunable Engineered Heart Tissue Platform
Next-generation engineered heart tissue platform that enables precise tuning of mechanical properties of microenvironment to study the structure, development, and function of cultured cells or human-derived cardiac tissues. Problem: Engineering heart tissue (EHT) platforms have the potential to study heart physiology, disease pathology, and therapeutic...
Published: 1/30/2026   |   Inventor(s): Kenneth Margulies, Benjamin Lee, Nesrine Bouhrira
Keywords(s): Bioengineering, Cardiovascular, Drug Target, Platform Technology
Category(s): Technology Classifications > Hardware & Components, Technology Classifications > Research Tools & Reagents, Technology Classifications > Testing & Measurement
Transgenic Mouse Model for Marfan Syndrome Research
Description: A genetically modified mouse model carrying the FBN1Q2469X mutation enables advanced study of systemic Marfan Syndrome manifestations and therapeutic development. This innovative transgenic mouse model incorporates a mutation analogous to the human FBN1Q2467X gene mutation linked to Marfan Syndrome, resulting in fibrillin-1 deficiency...
Published: 12/23/2025   |   Inventor(s): Li Li, Shichao Wu, Jiawei Zhao
Keywords(s):  
Category(s): Technology Category > Research tools, Technology Category > Animal models, Technology Category > Biology, Technology Category > Diagnostic
VASH1 Depletion for Heart Failure Therapy
Non-replicating viral delivery of shVASH1 to treat heart failure. Problem: Heart failure (HF) is condition in which the heart cannot pump enough blood throughout the body to meet its need. Approximately 6 million American adults live with the condition, and close to 400,000 people die from it annually. Mainstay treatment for HF are lifestyle changes...
Published: 8/21/2025   |   Inventor(s): Benjamin Prosser, Kenneth Margulies, Alexey Bogush
Keywords(s): Cardiovascular
Category(s): Technology Classifications > Therapeutics
Amphiphilic macromolecules with novel hydrophobic segments
­ ​ ​ Invention Summary: Cardiovascular diseases are the leading cause of mortality in developed countries. Atherosclerosis, defined as the buildup of lipid rich plaques within the vascular intima, is the foremost pathology underlying these conditions. This causes irregular uptake of oxidized low-density lipoproteins (OxLDL) which leads...
Published: 8/12/2025   |   Inventor(s): Kathryn Uhrich, Allison Faig, Dalia Abdelhamid, Li Gu
Keywords(s): Antibacterial, Biomaterials, Polymers & Composites
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
PMU-Embedded Analytics for Online Event Detection and Classification in Power Grids
The energy requirement of the world is increasing exponentially every year. With the power demand sites concentrated in the region with the highest population density, energy production sites must be located remotely. This isolation requires lengthy and complicated grids to be designed and manufactured to transmit power over long distances. Grid failures...
Published: 1/9/2026   |   Inventor(s): Payman Dehghanian, Shiyuan Wang, Li Li
Keywords(s):  
Category(s): Technology Classifications > Industrial or Consumer Tech > Energy Infrastructure and Environment
Lens with Electronically Controlled Optical Properties
Executive SummaryThis MSU-developed device allows for electrical control of the optical properties in a liquid lens and other optic devices. Capable of altering light’s focal point, this technology lends itself into many applications such as displays, microscopes, telescopes, interferometers, and many more. Description of TechnologyBy controlling...
Published: 8/20/2022   |   Inventor(s): Gary Blanchard, Greg Swain, Romana Jarosova, Ke Ma
Keywords(s):  
Category(s): Advanced Materials, Chemicals, Devices, Photonics
Distributed Feedback Fiber Laser Pumped by Multimode Diode Lasers
Researchers at the University of Arizona College of Optical Sciences and Canada's Carleton University recently succeeded in fabricating high reflectivity (>99%) Fiber Bragg Gratings (FBGs) into phosphate glass fibers using UV light and a phase mask technique. With this new manufacturing technique, fiber lasers can be created as single monolithic...
Published: 4/3/2023   |   Inventor(s): Nasser Peyghambarian, Axel Schülzgen, Li Li, Jacques Albert
Keywords(s):  
Category(s): Technology Classifications > Imaging & Optics, Technology Classifications > Imaging & Optics > Lasers & Other Sources
Algorithm for improved Spatial Sampling Design of DNAPL contaminants
SUMMARYImproved algorithm that reduces sampling required to monitor the remediation of Dense Nonaqueous Phase Liquid (DNAPL) contaminants in subsurface water.BACKGROUNDThe difficulties encountered in the remediation of Dense Nonaqueous Phase Liquid (DNAPL) contaminants in the subsurface have spawned numerous studies relating to evaluation of the benefits...
Published: 1/15/2025   |   Inventor(s): Linda Abriola, Ke Li
Keywords(s):  
Category(s): Software, Cleantech
All-Fiber Multicore Fiber Laser Devices
Researchers at the University of Arizona have developed a compact, power-scalable, alignment-free fiber laser that takes a new approach to stabilizing phase-locked operation of multi-core fiber lasers by completely removing all free space optical components. This high-brightness, all-fiber laser package uses passive optical fiber spliced at both ends...
Published: 4/3/2023   |   Inventor(s): Nasser Peyghambarian, Axel Schülzgen, Li Li
Keywords(s):  
Category(s): Technology Classifications > Imaging & Optics, Technology Classifications > Imaging & Optics > Fiber Optics, Technology Classifications > Imaging & Optics > Lasers & Other Sources