Search Results - kenneth+johnson

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Modified CRISPR-Cas9 system for enhanced gene editing
This invention enhances the CRISPR-Cas9 gene-editing system by modifying the Cas9 protein’s Rec3 clamp region, improving its fidelity, specificity, and speed, reducing off-target effects, and increasing precision for therapeutic and research applications. Background Genome engineering is a rapidly advancing field that involves the precise modification...
Published: 10/21/2024   |   Inventor(s): David Taylor, Kenneth Johnson, Jack Bravo, Tyler Dangerfield
Keywords(s):  
Category(s): Life sciences > Research tools > Reagent
SuperFi high-fidelity Cas9 enzyme eliminates off‑target CRISPR cleavage
Background The widespread use of CRISPR/Cas9 as a programmable genome editing tool has encountered hurdles, due to concerns about potential off‑target DNA cleavage by Cas9. While the analysis of off-target editing events has led to the develop­ment of Cas9 variants with greater sensitivity to mismatches, the underlying molecular mechanisms by which...
Published: 2/29/2024   |   Inventor(s): David Taylor, Kenneth Johnson, Jack Bravo, Mu-Sen Liu, Tyler Dangerfield
Keywords(s):  
Category(s): Life sciences > Research tools > Reagent
Mitochondrial-Targeted Peptide Modulators of Delta Protein Kinase C Interaction with the d-subunit of F1Fo ATP Synthase/ATPase as Therapeutics Against Cardiac Injury
Current State of the Art: Current clinical therapy for heart attack victims focuses on the rapid restoration of blood flow by thrombolysis, angioplasty, stenting and when appropriate surgical coronary artery bypass grafts. Problems with the Current Art: The majority of cardiac cell death associated with a heart attack actually occurs during the...
Published: 4/29/2020   |   Inventor(s): John Johnson, Tiffany Tuyen Nguyen, Mourad Ogbi
Keywords(s): Cardiovascular, Heart Attack, Therapeutics
Category(s): Therapeutics
Efficient & Broadband Even-Order Harmonic Multiplication in Standard CMOS
A novel technique to realize highly-efficient passive multipliers in a standard CMOS process is demonstrated to efficiently generate even-order harmonics while simultaneously suppressing odd-order harmonics over broad-bandwidths. This is achieved by improving the cutoff frequency (fT) well beyond a THz. The higher fT combined with proposed nonlinearity...
Published: 4/26/2019   |   Inventor(s): Kenneth O, Zeshan Ahmad
Keywords(s): Devices, Electronics, Engineering & Physical Sciences, Imaging, Optics & Photonics, Semiconductor, MEMS & Nanotechnology, Signal Processing, Wireless
Category(s): Communications