Search Results - david+taylor

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Harnessing the Type III-Dv CRISPR-Cas system for targeted RNA modification and detection
The Type III-Dv CRISPR-Cas system is a genetic tool designed for precise RNA targeting and cleavage. It uses a complex of Cas proteins to bind and modify single-stranded nucleic acids, enabling applications in gene silencing and RNA detection. Background The field of CRISPR-Cas technology has revolutionized genetic engineering by providing precise...
Published: 10/21/2024   |   Inventor(s): David Taylor, Peter Fineran, Robert Fagerlund, Leah Smith, David Mayo-Munoz, Evan Schwartz, Jack Bravo
Keywords(s):  
Category(s): Life sciences > Diagnostic, Life sciences > Research tools > Reagent
Modified CRISPR-Cas9 system for enhanced gene editing
This invention enhances the CRISPR-Cas9 gene-editing system by modifying the Cas9 protein’s Rec3 clamp region, improving its fidelity, specificity, and speed, reducing off-target effects, and increasing precision for therapeutic and research applications. Background Genome engineering is a rapidly advancing field that involves the precise modification...
Published: 10/21/2024   |   Inventor(s): David Taylor, Kenneth Johnson, Jack Bravo, Tyler Dangerfield
Keywords(s):  
Category(s): Life sciences > Research tools > Reagent
An RNA identification beacon based on Cas12a2
Background The CRISPR-Cas systems are adaptive immune mechanisms found in prokaryotes, primarily bacteria and archaea, which protect against invading genetic elements such as phages and plasmids. These systems have been harnessed for various biotechnological applications, including genome editing and molecular diagnostics. Cas12a2, a particular variant...
Published: 9/10/2024   |   Inventor(s): David Taylor, Ryan Jackson, Thomson Hallmark, Jack Bravo
Keywords(s):  
Category(s): Life sciences > Research tools > Reagent
SuperFi high-fidelity Cas9 enzyme eliminates off‑target CRISPR cleavage
Background The widespread use of CRISPR/Cas9 as a programmable genome editing tool has encountered hurdles, due to concerns about potential off‑target DNA cleavage by Cas9. While the analysis of off-target editing events has led to the develop­ment of Cas9 variants with greater sensitivity to mismatches, the underlying molecular mechanisms by which...
Published: 2/29/2024   |   Inventor(s): David Taylor, Kenneth Johnson, Jack Bravo, Mu-Sen Liu, Tyler Dangerfield
Keywords(s):  
Category(s): Life sciences > Research tools > Reagent
Stabilized Spinal Fixation Hook
Project ID: D2013-70 Invention Description and Novelty: Spinal hook achieves greater reliability for implantation, stabilization and poly-axial head movement, as well as reducing anatomical mismatch with the lamina, transverse process and pedicle before being locked by a rod and fastener. Value proposition: · Hook is shaped to engage multiple...
Published: 6/18/2024   |   Inventor(s): Anand Agarwal, Vijay Goel, John D'onofrio, Nathaniel Dubois, Jared Pack, David Taylor
Keywords(s): Fixation, Hook, Orthopaedic, Spine
Category(s): Spine, Medical Device