Search Results - john+(jay)+chiorini

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Cloning and Characterization of an Avian Adeno-Associated Virus and Uses Thereof
Currently, adeno-associated virus (AAV) represents the gene therapy vehicle of choice because it has many advantages over current strategies for therapeutic gene insertion. AAV is less pathogenic than other virus types; stably integrates into dividing and non-dividing cells; integrates at a consistent site in the host genome; and shows good specificity...
Published: 12/26/2024   |   Inventor(s): John (Jay) Chiorini, Ioannis Bossis
Keywords(s): GB2A2X, GB2AXX, GB2XXX, GB3XXX, GBXXXX, GXXXXX
Category(s): Collaboration Sought > Licensing, Application > Therapeutics
Diagnostic Test and Therapeutic Target for Sjogren's Syndrome
Sjögren's syndrome is an autoimmune disease that attacks salivary glands resulting in chronic dry mouth and dry eyes. Currently, there is no single diagnostic test to confirm the presence of Sjögren's. Physicians presently reach diagnosis after conducting a series of blood and functional tests for tear and salivary production. Diagnosis is further...
Published: 12/26/2024   |   Inventor(s): Melodie Weller, Hongen Yin, John (Jay) Chiorini
Keywords(s): Alteration, BMP6, Detection, Diagnosis, Expression, Gland, IA3XXX, IAXXXX, IXXXXX, LEVELS, Listed LPM Contreras as of 4/15/2015, Locally, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, Salivary, Sjogren's, Syndrome, treatment
Category(s): TherapeuticArea > Immunology, Application > Diagnostics, Application > Research Materials, Application > Therapeutics
Adeno-Associated Virus Gene Therapy for Diabetes and Obesity
This invention is directed to adeno-associated virus (AAV) vector delivery of exendin-4 (Ex-4) to salivary glands as treatment for diabetes and obesity. Ex-4 is a potent and long-acting agonist of the receptor for glucagon-like peptide 1 (GLP-1). Scientists at NIDCR have shown that AAV-mediated delivery of Ex-4 resulted in improved glucose homeostasis...
Published: 12/26/2024   |   Inventor(s): Giovanni Di Pasquale, Edward Mannucci, John (Jay) Chiorini
Keywords(s): DIABETES, EPITHELIA, Expression, Fusion, GBXXXX, Gland, IBXXXX, Listed LPM Contreras as of 4/15/2015, NGF/exendin-4, Novel, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, Protein, Salivary, treatment
Category(s): Application > Therapeutics
Identification of EGFR as A Receptor for AAV6 Transduction
AAV vectors offer unique advantages in gene therapy applications. Studies have shown that these replication deficient parvovirus vectors can deliver DNA to specific tissues and confer long-term transgene expression in a variety of systems. Although many studies have looked at the tissue-specific expression elicited by each of the AAV serotypes, a...
Published: 12/26/2024   |   Inventor(s): Michael Schmidt, Melodie Weller, John (Jay) Chiorini
Keywords(s): AAV6, EGFR, GB2A2X, GB2AXX, GB2XXX, GBXXXX, GXXXXX, Identification, RECEPTOR, transduction
Category(s): Application > Therapeutics, Collaboration Sought > Licensing
Scalable Purification of AAV2, AAV4 or AAV5 Using Ion-Exchange Chromatography
Adeno-associated viruses (AAVs) constitute, as a group, the vehicle of choice for gene therapy because of several attractive features. Among others, AAVs are less pathogenic than other viruses, and they can be used for the long-term expression of therapeutic genes. This invention describes a simple ion-exchange (HPLC) methodology to purify different...
Published: 12/26/2024   |   Inventor(s): John (Jay) Chiorini, Nikola Kaludov
Keywords(s): AAV2, AAV4, AAV5, CHROMATOGRAPHY., GB2DXX, GB2XXX, GBXXXX, GXXXXX, ION-EXCHANGE, purification, SCALABLE
Category(s): Application > Therapeutics
AAV5 Vector and Uses Thereof
The invention described and claimed in this patent application provides for novel vectors and viral particles which comprise adeno-associated virus serotype 5 (AAV5). AAV5 is a single-stranded DNA virus of either plus or minus polarity which, like other AAV serotypes (e.g., AAV4, AAV2) requires a helper virus for replication. AAV type 2 has the interesting...
Published: 10/28/2024   |   Inventor(s): Robert Kotin, John (Jay) Chiorini
Keywords(s): AAV, AAV5, control seq, Duke DNA Project, GB2A1X, GB2A2X, GB2AXX, GB2XXX, GBXXXX, GENE THERAPY, GXXXXX, Listed LPM Reichman as of 4/15/2015, Patent Category - Biotechnology, PCT/US99/11958; WO 99/61601 (12/02/99), Post LPM Assignment Set 20150420, Pre LPM working set 20150418, SACGHS DNA Patent Initial Set, viral vector
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Therapeutics
AAV5 Vector for Transducing Brain Cells and Lung Cells
The invention described and claimed in this patent application is related to the delivery of heterologous nucleic acids or genes to particular target cells. In particular, the application relates to methods of delivering a heterologous nucleic acid or gene of interest to particular target cells using an Adeno-Associated Virus of serotype 5 (AAV5)....
Published: 10/28/2024   |   Inventor(s): Beverly Davidson, Robert Kotin, Joseph Zabner, John (Jay) Chiorini
Keywords(s): AAV, AAV5, brain, CB2AXX, CBXXXX, CXXXXX, GB2A2X, GB2XXX, GENE THERAPY, IB4XXX, IBXXXX, IXXXXX, Listed LPM Reichman as of 4/15/2015, LUNG, NB1XXX, NBXXXX, NXXXXX, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, SACGHS DNA Patent Initial Set, USES, Vector, viral vector
Category(s): Collaboration Sought > Licensing, TherapeuticArea > Pulmonology, TherapeuticArea > Oncology, TherapeuticArea > Neurology, Application > Research Materials, Application > Diagnostics, Application > Therapeutics
AAV4 Vector and Uses Thereof
The invention described and claimed in this patent application relates to the delivery of heterologous nucleic acids or genes to particular target cells. In particular, the application relates to methods of delivering a heterologous nucleic acid or gene of interest to particular target cells using Adeno-Associated Virus of serotype 4 (AAV4). The particular...
Published: 10/28/2024   |   Inventor(s): Robert Kotin, Brian Safer, Beverly Davidson, John (Jay) Chiorini
Keywords(s): AAV, AAV4, brain, CB2AXX, CBXXXX, CXXXXX, ependymal cells, GB2A2X, GB2XXX, GENE THERAPY, Listed LPM Reichman as of 4/15/2015, NB1XXX, NBXXXX, NXXXXX, Patent Category - Biotechnology, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, SACGHS DNA Patent Initial Set, USES, viral vector
Category(s): Collaboration Sought > Licensing, TherapeuticArea > Oncology, Application > Therapeutics, TherapeuticArea > Neurology
Isolation, Cloning and Characterization of New Adeno-Associated Virus (AAV) Serotypes
Adeno-associated viruses (AAV) are used in gene delivery, but with limited success due to toxicity. The novel AAVs described in this technology may be more effective and useful in gene therapy applications. This invention relates to new adeno-associated viruses (AAV), vectors and particles derived therefrom and also provides methods for delivering...
Published: 10/28/2024   |   Inventor(s): John (Jay) Chiorini, Michael Schmidt
Keywords(s): Adeno-associated, CHARACTERIZATION, Cloning, GB2A2X, GB2AXX, GB2XXX, GBXXXX, GXXXXX, Isolation, Novel, Serotypes, virus
Category(s): Application > Therapeutics
AAV4 Vector And Uses Thereof
These patent applications describe the cloning and characterization of the full-length genome of adeno-associated virus type 4 (AAV4). AAV4, like other members of the AAV family, may be useful as a vector for gene therapy. When compared to AAV2, AAV4 may be better suited as a vector due to its larger size -- which permits efficient encapsidation of...
Published: 10/28/2024   |   Inventor(s): John (Jay) Chiorini, Robert Kotin, Brian Safer
Keywords(s): GB3XXX, GBXXXX, GXXXXX
Category(s): Collaboration Sought > Licensing, Application > Therapeutics
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