Search Results - gland

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Diagnostic Test and Therapeutic Target for Sjogren's Syndrome
Sjögren's syndrome is an autoimmune disease that attacks salivary glands resulting in chronic dry mouth and dry eyes. Currently, there is no single diagnostic test to confirm the presence of Sjögren's. Physicians presently reach diagnosis after conducting a series of blood and functional tests for tear and salivary production. Diagnosis is further...
Published: 12/26/2024   |   Inventor(s): Melodie Weller, Hongen Yin, John (Jay) Chiorini
Keywords(s): Alteration, BMP6, Detection, Diagnosis, Expression, Gland, IA3XXX, IAXXXX, IXXXXX, LEVELS, Listed LPM Contreras as of 4/15/2015, Locally, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, Salivary, Sjogren's, Syndrome, treatment
Category(s): TherapeuticArea > Immunology, Application > Diagnostics, Application > Research Materials, Application > Therapeutics
Adeno-Associated Virus Gene Therapy for Diabetes and Obesity
This invention is directed to adeno-associated virus (AAV) vector delivery of exendin-4 (Ex-4) to salivary glands as treatment for diabetes and obesity. Ex-4 is a potent and long-acting agonist of the receptor for glucagon-like peptide 1 (GLP-1). Scientists at NIDCR have shown that AAV-mediated delivery of Ex-4 resulted in improved glucose homeostasis...
Published: 12/26/2024   |   Inventor(s): Giovanni Di Pasquale, Edward Mannucci, John (Jay) Chiorini
Keywords(s): DIABETES, EPITHELIA, Expression, Fusion, GBXXXX, Gland, IBXXXX, Listed LPM Contreras as of 4/15/2015, NGF/exendin-4, Novel, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, Protein, Salivary, treatment
Category(s): Application > Therapeutics