Search Results - hiv%2faids

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CD4 mimetic small molecule inhibitors of HIV-1 entry
Therapeutic development for HIV-1 infection and prevention of transmission Problem: A global pandemic of human immunodeficiency virus (HIV) and acquired immunodeficiency syndrome (AIDS) persists, with about 34 million people worldwide currently infected and 2.5 million people newly infected with the virus annually. Inhibition of the initial HIV...
Published: 10/16/2023   |   Inventor(s): Amos Smith
Keywords(s): HIV/AIDS, Small Molecule
Category(s): Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Therapeutics
Accurate, High-Throughput Quantification of HIV Reservoirs Using Optical Scanning
HIV viral protein expression and functional virus reservoir size are rapidly and accurately quantified using optical scanning Problem: HIV can incorporate itself into the DNA of a host cell without producing circulating virus. When lying dormant in these reservoirs, HIV cannot be detected and eradicated by the immune system of the host. As most...
Published: 1/11/2024   |   Inventor(s): Una O'Doherty
Keywords(s): HIV/AIDS
Category(s): Technology Classifications > Diagnostics
A reverse transcription loop-mediated isothermal amplification method to quantify multiple HIV subtypes
A rapid, quantitative point-of-care diagnostics method for viral load detection of HIV-1 clades A, B, C, D, and G Problem: HIV infection remains an international health crisis, where it is especially acute in sub-Saharan Africa, despite the development of antiretroviral therapy. High sensitivity, point-of-care clinical diagnostic tests for detecting...
Published: 10/16/2023   |   Inventor(s): Haim Bau, Changchun Liu, Frederic Bushman
Keywords(s): HIV/AIDS
Category(s): Technology Classifications > Diagnostics, Technology Classifications > Research Tools & Reagents, Technology Classifications > Medical Devices
Novel Mouse Lines: A3 Knockout Mice Transgenically Expressing Either A3A or A3G
Strain Information: Laboratory mouse transgenically expressing human APOBEC3A protein on an APOBEC3 null background. The apolipoprotein B editing complex 3A – APOBEC3A or A3A – is one of seven members of the APOBEC3 family found in humans and other primates. The APOBEC3 family of cytidine deaminases function by removing amino groups from...
Published: 6/5/2024   |   Inventor(s): Susan Ross
Keywords(s): HIV/AIDS
Category(s): Technology Classifications > Research Tools & Reagents
High efficiency, superhydrophobic clamshell plasma separator for point-of-care diagnostics
Membrane-based, sedimentation-assisted plasma separator Problem: High sensitivity, point-of-care clinical tests, such as HIV viral load, require large volumes of plasma extracted from whole blood. Centrifugation is widely used for separating plasma, but it is not always accessible in resource-poor settings. Current microfluidic systems require...
Published: 10/16/2023   |   Inventor(s): Haim Bau, Changchun Liu, Michael Mauk
Keywords(s): HIV/AIDS
Category(s): Technology Classifications > Diagnostics, Technology Classifications > Medical Devices