Search Results - michael+mauk

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A homogenous self-heating, temperature-regulating composite material
A cost-effective homogenous, composite material provides sustained heat at a desired temperature for point-of-care diagnostics and other applications. Problem: Point-of-care (POC) diagnostic tests have the potential to greatly enhance patient care and accessibility by reducing the time and equipment necessary for testing. Many current POC tests require...
Published: 10/16/2023   |   Inventor(s): Haim Bau, Ruijie Li, Michael Mauk
Keywords(s): Bioengineering
Category(s): Technology Classifications > Diagnostics, Technology Classifications > Research Tools & Reagents, Technology Classifications > Materials
A method for highly selective nucleic acid enrichment for sensitive detection of mutations in cancer and genectic conditions.
This technology increases the fraction of clinically relevant, rare mutant alleles (DNA and/or RNA) to enable high sensitivity detection with common downstream methods such as capped (XNA or PNA) PCR, ddPCR, and sequencing. Problem: Liquid biopsy is a simple, minimally invasive, rapidly developing diagnostic method to analyze cell-free nucleic...
Published: 10/16/2023   |   Inventor(s): Jinzhao Song, Haim Bau, Michael Mauk, Jorrit Hegge, John van der Oost
Keywords(s):  
Category(s): Technology Classifications > Animal Health, Technology Classifications > Diagnostics, Technology Classifications > Medical Devices, Technology Classifications > Research Tools & Reagents
Nuclemeter: A yardstick for quantifying nucleic acids undergoing enzymatic amplification
Point-of-care, reaction-diffusion column-based, non-instrumented device for real-time visual measurement of viral load in resource-limited settings, in the clinic, and at home Problem: Quantification of viral load in patients is needed to assess disease progression, monitor drug therapy efficacy, and identify the emergence of drug-resistant strains,...
Published: 10/16/2023   |   Inventor(s): Haim Bau, Changchun Liu, Michael Mauk
Keywords(s): Nanotechnology
Category(s): Technology Classifications > Diagnostics, Technology Classifications > Research Tools & Reagents
High efficiency, superhydrophobic clamshell plasma separator for point-of-care diagnostics
Membrane-based, sedimentation-assisted plasma separator Problem: High sensitivity, point-of-care clinical tests, such as HIV viral load, require large volumes of plasma extracted from whole blood. Centrifugation is widely used for separating plasma, but it is not always accessible in resource-poor settings. Current microfluidic systems require...
Published: 10/16/2023   |   Inventor(s): Haim Bau, Changchun Liu, Michael Mauk
Keywords(s): HIV/AIDS
Category(s): Technology Classifications > Diagnostics, Technology Classifications > Medical Devices
Rapid plasma separator for point-of-care diagnostics and viral load detection that does not require electrical power
Membrane-based, sedimentation-assisted plasma separator from whole blood for clinical tests Problem: High sensitivity, point-of-care clinical tests, such as HIV load, require large volumes of plasma. Centrifugation is widely used for separating plasma from whole blood, but it is not always accessible and can be a limiting factor for point-of-care...
Published: 10/16/2023   |   Inventor(s): Haim Bau, Changchun Liu, Michael Mauk
Keywords(s): Microfluidics
Category(s): Technology Classifications > Diagnostics, Technology Classifications > Medical Devices