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In the Americas with David Yetman is an HDTV series that takes an in depth look at the heartland of Arizona, New Mexico, Sonora, and Chihuahua, and its peripheries and brings the region into the spotlight for the general audience. This show undertakes a new approach to travel and adventure with a focus on the western continents and islands. Season 10...

Published: 7/29/2024 | Inventor(s): A Departmental Work

Keywords(s):

Category(s): Technology Classifications > Creative Works

Compounds and Methods for Treating Cancer by Destroying Cancer Stem Cells (UCLA Case No. 2021-286)

Researchers from UCLA’s Department of Chemistry and Biochemistry and the Department of Radiation Oncology have synthesized a set of compounds for the eradication of cancer stem cells. These compounds are predicted to cross the blood brain barrier and show promise as effective interventions for glioblastoma in both in vitro and in vivo assays. BACKGROUND:...

Published: 7/11/2024 | Inventor(s): Michael Jung, Frank Pajonk

Keywords(s): blood-brain barrier, Brain, Cancer, Cancer stem cells, drug screening, GBM, Glioblastoma, Glioma, new chemical entity

Category(s): Therapeutics > Oncology, Therapeutics > CNS and Neurology, Therapeutics > Stem Cells And Regenerative Medicine

Core Administrative Program Suite

This technology comprises a comprehensive set of user-friendly business tools designed to enhance and streamline Core Facilities operations. It includes features like managing purchasing requests, reconciling procurement cards (p-cards), and controlling inventory. These tools are specifically tailored to meet the needs of Core Facilities, providing...

Published: 7/10/2024 | Inventor(s): A Departmental Work

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Category(s): Technology Classifications > Software & Information Technology > Education & Training

Neurodiverse Learners Endorsement & Training Program

The Strategic Alternative Learning Techniques (SALT) Center is an international leader in developing and providing personal, educational, and mental health/wellness services to support higher education students who learn differently. The SALT Center’s Neurodiversity Endorsement & Training Program helps university leaders, faculty, staff and...

Published: 8/23/2024 | Inventor(s): A Departmental Work

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Category(s): Technology Classifications > Creative Works, Technology Classifications > Healthcare Portfolios > Neurology > Mental Health, Technology Classifications > Software & Information Technology > Education & Training

Combating Opioid-Induced Respiratory Depression Using Setmelanotide

The opioid crisis is a serious public health crisis in the United States. Mortality from opioid overdose increased by roughly ten times from 1999 to 2021. The primary cause of death is due to opioid-induced respiratory depression (OIRD). Currently, Naloxone and Nalmefene are actively used to reverse OIRD in emergency settings and by first responders....

Published: 7/30/2024 | Inventor(s): Vsevolod Polotsky, David Mendelowitz, O Aung, Mateus Ramos Amorim, Joan Escobar

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Category(s): Technology Classifications > Therapeutics > Small Molecules, Technology Classifications > Therapeutics > Repurposed Drugs

Mentoring Best Practices for Faculty and Graduate Students

This is a professional development training developed by the MENTOR (Mentorship through Effective Networking, Transformational Opportunities, and Research) Institute at the University of Arizona. The purpose is to enhance mentoring practices as a means to improve outcomes such as career advancement, obtaining a great job, timely promotion, academic...

Published: 9/10/2024 | Inventor(s): A Departmental Work

Keywords(s):

Category(s): Technology Classifications > Creative Works

PRIME: A Personalized Recommendation for Information Visualization Methods via Extended matrix Completion

Information visualization is an important mode of human-computer interaction to acquire insights of complex datasets. However, a uniform visualization format may be inefficient to bring the insights to different users at different contexts due to the users' differences in knowledge, perception, and cognition capabilities. On the other hand, typical...

Published: 10/27/2023 | Inventor(s): Ran Jin, Chen Xiaoyu, Nathan Lau

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Category(s): Technology Classifications > Software, Technology Classifications > Communication

T Cell Receptors Targeting CDKN2A Mutations for Cancer Immunotherapy

Abstract: Cyclin-dependent kinase inhibitor 2A gene, also known as CDKN2A, is a tumor suppressor gene and is commonly inactivated through somatic mutations in many human cancers. For example, inactivation of CDKN2A is highly prevalent in melanoma, gastrointestinal and pancreatic cancers. Through germline mutations, CDKN2A is associated with predisposition...

Published: 4/8/2024 | Inventor(s): Sri Krishna, Shoshana Levi, Paul Robbins, Steven Rosenberg, Shirley Nah, Rami Yoseph, Frank Lowery

Keywords(s): adoptive cell therapy, CDKN2A, cyclin dependent kinase inhibitor 2A, Immunotherapy, Krishna, MELANOMA, Neoantigen, Rosenberg, T Cell Receptor, TCR

Category(s): Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Oncology, Collaboration Sought > Collaboration

Non-invasive diagnostic and prognostic assay for early stage lung cancer

Abstract: In the United States alone, one of four cancer deaths occur from lung cancer and there are over 8 million individuals considered to be at high-risk due to cigarette smoking and other behaviors. It's well known that early detection of cancer significantly improves survival of this disease, however a lack of lung cancer screenings and analysis...

Published: 4/8/2024 | Inventor(s): Curtis Harris, Ewy Mathe, Frank Gonzalez, Kristopher Krausz, Soumen Manna, Andrew Patterson, Majda Haznadar

Keywords(s): LDCT, LD-CT, liquid biopsy, low-dose computed tomography, Non-small cell lung cancer, NSCLC, Urine

Category(s): TherapeuticArea > Oncology, Collaboration Sought > Collaboration, Application > Diagnostics, Collaboration Sought > Licensing

Extremely Rapid Method to Isolate Neoantigen Reactive T Cell Receptors (TCRs)

Abstract: Adoptive cell transfer (ACT) uses tumor infiltrating lymphocytes (TILs) that recognize unique antigens expressed by cancer cells (“neoantigens”). Neoantigen specific TIL administration in patients has resulted in long term regression of certain metastatic cancers. However, one of the challenges of ACT and engineered T cell receptor (TCR) therapies...

Published: 4/8/2024 | Inventor(s): Sri Krishna, Paul Robbins, Rami Yoseph, James Yang, Kenichi Hanada, Frank Lowery, Steven Rosenberg

Keywords(s): act, Adoptive Cell Transfer, Immunotherapy, Neoantigen, Rosenberg, T Cell Receptor, TCR, TIL, tumor, Tumor Infiltrating Lymphocyte

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Therapeutics, TherapeuticArea > Oncology

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