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Search Results - enzyme%2fprotein
13
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Whole-Animal Genetic Model to Mimic Aspects of the Patient Phenotype of Classic Galactosemia
Application An animal model for studying the underlying causes of galactosemia and screening for novel drugs to treat the condition. Key Benefits The first animal model for elucidating the underlying causes of galactosemia in infants. Animals with galactosemia causing genetic knockout exhibit similar disease phenotypes and complications...
Published: 7/30/2024
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Inventor(s):
Judith Fridovich-Keil
Keywords(s):
Animal Model
,
Enzyme/Protein
,
Genetic Disorders
,
Metabolic Diseases
,
Rare/Orphan Diseases
Category(s):
TechPub Algolia > Research Tools
Strategy to Identify miRNAs for Disease Diagnosis
Application Method to measure precursor and mature miRNA specifically. Key Benefits Unique primers can specifically identify miRNAs and precursor miRNAs by standard qRT-PCR without the requirement for an additional detection probe. Allows for amplification and quantification of both mature miRNA and precursor miRNAs. Potential technology to evaluate...
Published: 9/26/2024
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Inventor(s):
Wenming Li
Keywords(s):
Enzyme/Protein
,
Neuroscience/Pain
,
Oncology
Category(s):
TechPub Algolia > Research Tools
Glycoprotein Tetramer for Identifying Antigen-specific B Cells
Application Ectodomain of viral glycoprotein tetramers detects antigen-specific memory B Cells. Key Benefits Viral glycoprotein tetramers detect antigen-specific memory B cells in the peripheral blood and tissues. Hepatitis C virus E2 protein triggers immune response, which may yield an effective vaccine against hepatitis C virus. Market Summary Hepatitis...
Published: 10/28/2024
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Inventor(s):
Arash Grakoui
,
Joseph Marcotrigiano
Keywords(s):
Antibody
,
Enzyme/Protein
,
Immunology/Inflammation
Category(s):
TechPub Algolia > Vaccines
,
TechPub Algolia > Diagnostics
Granulin for Treatment of Neurodegeneration
Application Granulin proteins (GRNs) as potential therapeutics for multiple neurodegenerative disorders caused by lysosome dysfunction and inflammation. Key Benefits Novel pathway and target provides new route for treatment. Granulins shown to rescue lysosomal defects in cell culture models. Market Summary Granulins are small proteins that...
Published: 11/20/2024
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Inventor(s):
Thomas Kukar
,
Christopher Holler
,
Georgia Taylor
Keywords(s):
Biologic
,
Enzyme/Protein
,
Neuroscience/Pain
Category(s):
TechPub Algolia > Therapeutics
,
TechPub Algolia > Diagnostics
TaqMan Array Cards for Pneumococcal Detection and Serotyping
ApplicationDiagnostic for identifying Streptococcus pneumonia serotypes.Key BenefitsAllows for rapid detection and serotype identification of Streptococcus pneumonia infections.Market SummaryStreptococcus pneumonia (Spn) is a gram-positive bacteria and significant human pathogen responsible for most pneumonia cases. Typically, Spn resides asymptomatically...
Published: 7/30/2024
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Inventor(s):
Jorge Vidal Graniel
,
Fuminori Sakai
,
Lesley McGee
,
Velusamy Srinivasan
Keywords(s):
Enzyme/Protein
,
Microbiology/Infectious Diseases
Category(s):
TechPub Algolia > Diagnostics
Therapeutic Target for Hepatic Fibrosis
ApplicationPeriostin as a therapeutic target for liver disease.Key BenefitsNew therapeutic target for preventing fibrosis from entering cirrhosis stage.Therapeutic target may be used for identifying new therapy for fibrosis.Market SummaryCirrhosis is a condition in which the liver is unable to function normally due to chronic, or long lasting, injury....
Published: 11/20/2024
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Inventor(s):
Frank Anania
,
Pradeep Kumar
Keywords(s):
Enzyme/Protein
,
Hepatology
,
Immunology/Inflammation
,
Target
Category(s):
TechPub Algolia > Therapeutics
,
TechPub Algolia > Drug Discovery
Targeting Peptide Improves Accurate Myocarditis Imaging and Diagnosis
ApplicationTargeting peptide molecule for image-based diagnosis of myocarditis.Key BenefitsEnables noninvasive diagnosis of myocarditis.Targets and binds to biomarker of myocarditis.Market SummaryMyocarditis is an inflammation of the heart muscle (myocardium). Myocarditis can affect your heart muscle and your heart's electrical system, reducing the...
Published: 7/30/2024
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Inventor(s):
Michael E. Davis
,
Mario Martinez
Keywords(s):
Biomarker
,
Cardiovascular
,
Enzyme/Protein
,
Imaging
,
Target
Category(s):
TechPub Algolia > Diagnostics
DHAA and Derivatives for Treatment of BRAF-V600E-Positive Cancer
Application Hypolipidemic dehydroacetic acid (DHAA) treatment to prevent growth of BRAF V600E positive tumors. Key Benefits Treatment with slows BRAF V600E-positive tumor growth. Repurposed compound may speed FDA approval. May be used in combination with other therapies. Market Summary Up to 50% of melanoma cases harbor the BRAF V600E mutation,...
Published: 11/20/2024
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Inventor(s):
Jing Chen
,
Jack Arbiser
,
Brian Pollack
,
Siyuan Xia
Keywords(s):
Enzyme/Protein
,
Oncology
,
Repurposed Drug
Category(s):
TechPub Algolia > Therapeutics
Bioluminescent Ion Indicator Proteins
ApplicationFusion protein for non-invasive assessment of chloride fluctuations in neuronal processes.Key BenefitsEnables a non-invasive method of imaging chloride in animals.Offers high signal-to-noise ratio compared to fluorescent light.Market SummaryNeuronal chloride (Cl-) is involved in many normal neurophysiological activities, including synaptic...
Published: 11/20/2024
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Inventor(s):
Robert E. Gross
,
Ken Berglund
,
Jack Tung
Keywords(s):
Biomarker
,
Enzyme/Protein
,
Imaging
,
Neuroscience/Pain
Category(s):
TechPub Algolia > Research Tools
Compound and Method to Explore and Prepare O-Glycans from Living Cells
ApplicationChemical compound and method that enables detection of O-glycans with higher sensitivity than conventional approaches.Key BenefitsHigher accuracy and sensitivity than current β-elimination method.Smaller sample quantities required compared to traditional mass spectrometry.Method promotes the discovery of novel glycans and study of cellular...
Published: 9/26/2024
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Inventor(s):
Tongzhong Ju
,
Richard Cummings
,
Matthew Kudelka
Keywords(s):
Biomarker
,
Enzyme/Protein
Category(s):
TechPub Algolia > Diagnostics
,
TechPub Algolia > Research Tools
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