Search Results - enzyme%2fprotein

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Novel Endoglycosidase Derivatives Treating Diseases of the Adaptive Immune System
Application Protein-based therapeutics for the treatment of IgG-mediated diseases. Key Benefits A new class of endoglycosidases for the treatment of IgG-mediated diseases. Four novel compounds have been developed that exhibited robust in vitro activity. Potential to become first-in-class medications for dysregulation of the adaptive immune system,...
Published: 8/22/2024   |   Inventor(s): Eric Sundberg, Diego Sastre, Jonathan Du, Jeffrey Ravetch, Stylianos Bournazos
Keywords(s): Enzyme/Protein, Immunology/Inflammation, Metabolic Diseases, Oncology
Category(s): TechPub Algolia > Therapeutics
Whole-Animal Genetic Model to Mimic Aspects of the Patient Phenotype of Classic Galactosemia
­ Application An animal model for studying the underlying causes of galactosemia and screening for novel drugs to treat the condition. Key Benefits The first animal model for elucidating the underlying causes of galactosemia in infants. Animals with galactosemia causing genetic knockout exhibit similar disease phenotypes and complications...
Published: 7/30/2024   |   Inventor(s): Judith Fridovich-Keil
Keywords(s): Animal Model, Enzyme/Protein, Genetic Disorders, Metabolic Diseases, Rare/Orphan Diseases
Category(s): TechPub Algolia > Research Tools
Functionalized Collagen Biochips with Core-Shell Structures and Collagen-Mimetic Peptide Nanotubes
Application Synthetic collagen-based biomaterials for therapeutic delivery or drug testing. Key Benefits Synthetic collagen substitute. Capable of formulating into various structures. Free of animal-based contaminants. Able to be spatially patterned. Market Summary Organ failure and tissue defects affect millions of Americans, resulting in...
Published: 8/22/2024   |   Inventor(s): Vincent Conticello, Andrea Merg, Gavin Touponse
Keywords(s): Biomaterials, Enzyme/Protein
Category(s): TechPub Algolia > Micro and Nanotechnology
KRAS Mutant Protein-Protein Interaction Targets and Inhibitors for Cancer Therapy
Application Immunotherapeutic agent and biosensor for KRASG12V mutation in tumor cells. Key Benefits First in class, targeted immunotherapy for patients presented with KRASG12V mutation. Attenuates immune suppression associated with KRASG12V-positive cancers. Market Summary The KRASG12V mutation, representing 85% of all cancer mutations, is...
Published: 8/22/2024   |   Inventor(s): Haian Fu, Cong Tang, Xiulei Mo
Keywords(s): Enzyme/Protein, Immunology/Inflammation, Oncology, Target
Category(s): TechPub Algolia > Drug Discovery, TechPub Algolia > Therapeutics
Caspase-3 Deficient MEFs with Mutant Caspase-3 Re-Introduced
Application Mouse embryonic fibroblast (MEF) line deficient in caspase-3 that are reconstituted with constitutively expressed mutant versions of the protease. Key Benefits An immortalized caspase-3-deficient MEF cell line. Tool to study protease induced apoptosis. Technical Summary Emory inventors have discriminated a previously unknown role...
Published: 7/30/2024   |   Inventor(s): Lawrence Boise, Katelyn Ponder
Keywords(s): Cell Line, Enzyme/Protein
Category(s): TechPub Algolia > Research Tools
Photocaged Cytokines for Cancer Immunotherapy
Application Light-responsive cytokine prodrugs with controlled activation for improved cancer immunotherapy. Key Benefits Spatiotemporal control of therapeutic cytokine activation leads to controlled local activation and reduces off-target toxicity. Prolonged circulation means less frequent dosing is required. Biased activity towards CD8+ T-cells...
Published: 7/30/2024   |   Inventor(s): Erik Dreaden, Lacey Perdue, Priscilla Do
Keywords(s): Biologic, Enzyme/Protein, Immunology/Inflammation, Oncology
Category(s): TechPub Algolia > Therapeutics
Ribosome Pegging: An Antibiotic-free System to Produce Recombinant Proteins
Application Antibiotic-free method to prevent the growth of cells that fail to express high levels of a non-essential protein (target protein). Key Benefits Prevents the use of antibiotics and markers that promote resistance. Facilitates the deployment of recombinant bacteria in uncontrolled environments. Stabilizes heterologous expression of...
Published: 7/30/2024   |   Inventor(s): Ichiro Matsumura
Keywords(s): Enzyme/Protein, Platform
Category(s): TechPub Algolia > Research Tools
Strategy to Identify miRNAs for Disease Diagnosis
Application Method to measure precursor and mature miRNA specifically. Key Benefits Unique primers can specifically identify miRNAs and precursor miRNAs by standard qRT-PCR without the requirement for an additional detection probe. Allows for amplification and quantification of both mature miRNA and precursor miRNAs. Potential technology to evaluate...
Published: 7/30/2024   |   Inventor(s): Wenming Li
Keywords(s): Enzyme/Protein, Neuroscience/Pain, Oncology
Category(s): TechPub Algolia > Research Tools
Selective Enrichment of A-To-I Edited Transcripts from Cellular RNA Using Endonuclease V
Application Kit to efficiently identify and enrich adenosine-to-inosine (A-to-I) editing in RNA molecules. Key Benefits Robust and facile method for enriching A-to-I edited transcripts. Overcomes the low efficiency and accuracy of transcriptome-wide RNA-seq. Market Summary A-to-I RNA editing by adenosine deaminases is a common RNA modification...
Published: 8/22/2024   |   Inventor(s): Steven Knutson, Jennifer Heemstra
Keywords(s): Enzyme/Protein
Category(s): TechPub Algolia > Research Tools
Cas9 Controlled Gene Activation
Application Flexible system using Cas9 to modulate gene expression. Key Benefits Edits genes by cleaving DNA as well as inhibiting transcription. No need to transfect cells with additional Cas9. Market Summary The CRISPR-Cas9 system is a bacterial adaptive immune system that has been appropriated for genetic engineering. The CRISPR-Cas9 system...
Published: 8/22/2024   |   Inventor(s): David Weiss, Hannah Ratner
Keywords(s): Cell/Gene Therapy, Enzyme/Protein, Genetic Disorders, Platform
Category(s): TechPub Algolia > Therapeutics
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