Search Results - diagnostic+markers+%3e+immunology

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Control of Periprosthetic Joint Infections (Case No. 2021-334)
Summary: UCLA researchers in the Department of Orthopaedic Surgery have developed a non-invasive method to disrupt biofilms on orthopaedic implants and decrease the overall rate of infections. Background: Prosthetic joint infection (PJI) remains a serious complication in hip and knee arthroplasty, with skyrocketing revision rates across all orthopaedic...
Published: 9/23/2024   |   Inventor(s): Fabrizio Billi, Beth Lazazzera
Keywords(s): Biofilm, Cell Growth, electromagnetic, Infection, Nanoparticle, Orthopaedics, Orthopedics and Prosthetics (O & P), Osteo, Prosthetics
Category(s): Medical Devices > Prosthetics, Chemical > Coatings, Adhesives & Inks, Diagnostic Markers > Immunology, Materials > Membranes, Medical Devices > Coatings, Therapeutics > Orthopaedics
Affinity and Functional Based Screening of T Cell Receptor Repertoire Using Nanovials (Case No. 2024-042)
Summary: Researchers in the Department of Bioengineering at UCLA have developed a hydrogel platform that measures single T cell secretions, aiding in the definition of T cell receptor repertoires for functional immunotherapy applications. Background: T cell immunotherapies, namely T cell receptor (TCR) therapies, have emerged as promising candidates...
Published: 9/20/2024   |   Inventor(s): Dino Di Carlo, Owen Witte, Doyeon Koo, Zhiyuan Mao
Keywords(s): Cancer Immunotherapy, CAR-T cell therapy, Flow Cytometry, hydrogel, Immunooncology, Immunotherapy, Peptide, single cell analysis, T Cell, T cell based therapy
Category(s): Diagnostic Markers > Immunology, Life Science Research Tools > Screening Libraries, Therapeutics > Immunology And Immunotherapy
A Method and System for Pre-processing Medical Images (Case No. 2024-177)
Summary: UCLA researchers in the Department of Electrical and Computer Engineering have developed a novel pre-processing computer algorithm for automated medical imaging. Background: The integration of machine learning and artificial intelligence into medical imaging applications offers significant potential to automate the diagnosis of various...
Published: 7/23/2024   |   Inventor(s): Bahram Jalali, Callen MacPhee, Yiming Zhou, Koichiro Kishima
Keywords(s): 3D ultrasound imaging, Artificial Intelligence, bioimaging, Computer Vision, histopathology images, Machine Learning, Medical Imaging, MRI, X-Ray
Category(s): Diagnostic Markers > Cancer, Diagnostic Markers > Immunology, Software & Algorithms > Artificial Intelligence & Machine Learning, Software & Algorithms > Digital Health, Software & Algorithms > Image Processing
2022-140 Label-Free Virtual HER2 Immunohistochemical Staining of Breast Tissue Using Deep Learning
SUMMARY: UCLA researchers in the Departments of Bioengineering and Electrical and Computer Engineering have developed a deep learning-based algorithm that can detect and quantify the breast cancer marker human epidermal growth factor receptor 2 (HER2) in microscopic images without the need for time-consuming immunohistochemical staining (IHC). BACKGROUND:...
Published: 4/9/2024   |   Inventor(s): Aydogan Ozcan, Yair Rivenson, Bijie Bai, Hongda Wang
Keywords(s): Artifical Intelligence (Machine Learning, Data Mining), Biomarker, Bladder Cancer, Breast Cancer, Cancer, Cancer Immunotherapy, Computer Aided Learning, Diagnostic Markers & Platforms, Diagnostic Test, Fluorescence, Fluorescent Labelling, HER2/Neu, Histology, Immune System, Immunohistochemistry, Life Science Research Tools, Machine Learning, Optics, Research Methods, Unsupervised Learning
Category(s): Life Science Research Tools, Life Science Research Tools > Research Methods, Diagnostic Markers, Diagnostic Markers > Immunology, Medical Devices > Medical Imaging, Medical Devices > Medical Imaging > Fluorescence, Software & Algorithms > Artificial Intelligence & Machine Learning, Optics & Photonics
2021-260: THE INNATE IMMUNE HEALTH SCORE
SUMMARY: UCLA researchers in the Department of Microbiology, Immunology, and Molecular Genetics have developed a strategy to quantitatively assess the functionality of macrophages, a key player of the innate immune system, using a paired experimental and computational strategy. BACKGROUND: The immune system is formed by two major inter-related components,...
Published: 9/5/2023   |   Inventor(s): Alexander Hoffmann
Keywords(s):  
Category(s): Software & Algorithms > Bioinformatics, Diagnostic Markers > Immunology, Therapeutics > Immunology And Immunotherapy, Therapeutics > Infectious Diseases, Therapeutics > Inflammation And Inflammatory Diseases
2021-108 PRECISION CONTROL OF TACROLIMUS SERUM LEVEL FOR IMMUNOSUPRESSION OF POST ORGAN TRANSPLANT PATIENTS
Researchers from UCLA’s Department of Mechanical and Aerospace Engineering and the Department of Psychology have created a new approach for the precise management of tacrolimus, improving patient outcomes following organ transplants. This method proved successful in a 60 patient clinical trial compared to controls and can be applied to other similar...
Published: 11/13/2023   |   Inventor(s): Chih-Ming Ho, Jeffrey Huy Khong, Megan Lee, Ali Zarrinpar, Un Bi (Viki) Kim
Keywords(s): Organ Transplant
Category(s): Diagnostic Markers > Immunology
2021-007 Point of Care Electrochemical Immunosensor for the Detection of COVID-19
Summary: UCLA researchers in the Department of Electrical and Computer Engineering have developed a wireless, sensitive, and disposable Point of Care (PoC) electrochemical immunosensor for the detection of COVID-19 antibodies. Background: COVID-19 is detected using two main methods: nucleic acid testing and the serological testing. Point-of-Care...
Published: 8/23/2024   |   Inventor(s): Aydin Babakhani
Keywords(s):  
Category(s): Diagnostic Markers > Immunology, Platforms > Diagnostic Platform Technologies, Therapeutics > Infectious Diseases > COVID
2021-002 System and Methods for Amplified Detection of Molecules on Microparticles
SUMMARYUCLA researchers in the Department of Bioengineering have developed a system to build immunocomplexes, generate and accumulate amplified signals, and perform the signal readout of a digital ELISA using standard benchtop instruments and techniques.BACKGROUNDDigital ELISA allows for the detection and measurement of protein biomarkers at a single-molecule...
Published: 7/19/2023   |   Inventor(s): Dino Di Carlo, Yilian Wang, Vishwesh Nilesh Shah
Keywords(s):  
Category(s): Life Science Research Tools > Research Methods, Life Science Research Tools > Lab Equipment, Life Science Research Tools > Antibodies, Diagnostic Markers > Immunology, Diagnostic Markers > Targets And Assays, Platforms > Diagnostic Platform Technologies
2019-726 AUGMENTATING T-CELL ACTIVATION BY OSCILLATORY FORCES AND ENGINEERED ANTIGEN-PRESENTING CELLS
UCLA researchers in the Department of Pediatrics have developed a suite of novel spherical aAPCs of varying sizes and densities, that can be coupled with an oscillatory stimulus to promote efficient T cell activation: offering the possibility to aptly engineer T cells for a variety of clinical and experimental needs. BACKGROUND:T cells circulate throughout...
Published: 9/5/2023   |   Inventor(s): Manish Butte, Fatemeh Sadat Majedi
Keywords(s): Immunology, Immunotherapy, Life Science Research Tools, Oncology, Oncology Immunotherapy
Category(s): Life Science Research Tools > Antibodies, Life Science Research Tools > Research Methods, Diagnostic Markers > Immunology, Therapeutics > Oncology > Oncology Immunotherapy
2019-880 ZIKA VIRUS-BASED ONCOLYTIC THERAPY FOR BRAIN CANCER
UCLA researchers in the Department of Molecular and Medical Pharmacology have developed a novel zika virus-based oncolytic therapy to treat brain cancer.BACKGROUND: Glioma is a type of brain tumor that accounts for 80% of all primary malignant brain tumors. Standard therapy for high-grade glioma requires a combination of surgical resection, radiation...
Published: 9/12/2023   |   Inventor(s): Vaithilingaraja Arumugaswami, David Nathanson
Keywords(s): Cns, Drug Delivery, Gene Editing Systems, Gene Therapy, Immunology, Immunotherapy, Oncology, Oncology Immunotherapy, Plasmids / Vectors, Therapeutics & Vaccines, Viral Delivery Systems
Category(s): Diagnostic Markers > Immunology, Therapeutics > CNS and Neurology, Therapeutics > Vaccines, Therapeutics > Oncology, Therapeutics > Gene Therapy And Editing, Therapeutics > Oncology > Oncology Immunotherapy
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