Search Results - danielle+liu

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In normal differentiated cells, most of the genome is densely methylated, except CpG islands near promoters of actively transcribed genes. Maintaining this boundary between unmethylated promoter-associated and adjacent methylated regions is crucial as loss of segregation can lead to disease. Unfortunately, it is not clear where these boundaries are,...

Published: 6/5/2024 | Inventor(s): Li Liu, Jingmin Shu

Keywords(s):

Category(s): Applied Technologies, Genomic Assays/Reagents/Tools, Life Science (All LS Techs), Diagnostic Assays/Devices

High Affinity Nanobodies Targeting B7-H3 (CD276) for Treating Solid Tumors

Abstract: CD276 (also called B7-H3) is a pan-cancer antigen expressed in multiple solid tumors and an emerging cancer target. CD276 protein is overexpressed in pancreatic cancer, prostate cancer, breast cancer, colon cancer, lung cancer, and brain tumors (such as neuroblastoma) – making it an ideal target for cancer therapy. Investigators at the National...

Published: 5/21/2024 | Inventor(s): Mitchell Ho, Brad St. Croix, Ruixue Wang, Dan Li

Keywords(s): ADC, Antibody-drug Conjugate, B7-H3, BREAST CANCER, CAR, CD276, chimeric antigen receptor, COLON CANCER, Glioma, HO, lung cancer, Nanobodies, Neuroblastoma, OVARIAN CANCER, Pancreatic Cancer, solid tumors

Category(s): Application > Therapeutics, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Oncology

Combination of recombinant IL-7 with Chimeric Antigen Receptor (CAR) T Cells Targeting Glypican-3 (GPC3) for the Treatment of Hepatocellular Carcinoma (HCC)

Abstract: Hepatocellular carcinoma (HCC) is the most common type of liver cancer. standard treatment for HCC is not suitable for a large proportion of liver cancer patients. As a result, alternative treatments are needed. Chimeric antigen receptor (CAR) T cell therapy is a promising alternative approach selectively targets targeting tumors via tumor-specific...

Published: 5/21/2024 | Inventor(s): Mitchell Ho, Dan Li, Byung Ha Lee, Sara Ferrando-Martinez

Keywords(s): CAR, Chimeric Antigen Receptor T Cell Therapy, Glypican-3, GPC-3, HCC, hepatocellular carcinoma, HO, Interleukin-7, liver, Recombinant IL-7, Tumor Specific Antigen

Category(s): TherapeuticArea > Oncology, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Immunology, Application > Therapeutics

New Chimeric Antigen Receptor (CAR) Format for Developing Improved Adoptive Cell Therapies

Abstract: Adoptive cell therapy (ACT) is an attractive new therapeutic approach for treating various cancers. ACT has recently demonstrated a high degree of efficacy when treating patients with hematological malignancies. However, to date, no effective Chimeric Antigen Receptors (CAR) T cell therapy exists for solid tumors. Researchers in the National...

Published: 5/21/2024 | Inventor(s): Mitchell Ho, Nan Li, Dan Li

Keywords(s): CANCER, chimeric antigen receptor (CAR), GPC2, GPC3, HO, MESOTHELIN, solid tumor, tumor antigen

Category(s): Application > Therapeutics, Collaboration Sought > Licensing, Collaboration Sought > Collaboration, TherapeuticArea > Oncology

Cross Species Single Domain Antibodies Targeting PD-L1 for Treating Solid Tumors

Abstract: Programed Death-Ligand 1 (PD-L1, also known as B7-H1 or CD274) is a cell surface protein that binds to Programmed Cell Death Protein 1 (PD-1, also known as CD279). An imbalance in PD-1/PD-L1 activity contributes to cancer immune escape. PD-1 is expressed on the surface of antigen-stimulated T cells. The interaction between PD-L1 and PD-1...

Published: 4/8/2024 | Inventor(s): Mitchell Ho, Glenn Merlino, Dan Li, Hejiao English, Chi-Ping Day

Keywords(s): adoptive cell therapy, Chimeric Antigen Receptor T Cells, HO, ICI, Immune Checkpoint Inhibitor, Immunotherapy, NANOBODY, PD-L1, phage display, Programed Death-Ligand, Single Domain Antibody

Category(s): Collaboration Sought > Collaboration, Application > Therapeutics, Collaboration Sought > Licensing, TherapeuticArea > Oncology

Alluaudite Nanoplates as Cathode Materials for Sodium Rechargeable Batteries

Overview Current lithium-ion (Li-ion) battery technology is limited in terms of energy capacity, charging speed, and manufacturing cost. We have invented new alluaudite compounds for use as cathode materials for sodium-ion (Na-ion) batteries, which will enable large-scale battery applications that are naturally abundant and sustainable. Market Opportunity The...

Published: 7/25/2023 | Inventor(s): Tayhas Palmore, Dan Liu

Keywords(s):

Category(s): Energy

PMU-Embedded Analytics for Online Event Detection and Classification in Power Grids

The energy requirement of the world is increasing exponentially every year. With the power demand sites concentrated in the region with the highest population density, energy production sites must be located remotely. This isolation requires lengthy and complicated grids to be designed and manufactured to transmit power over long distances. Grid failures...

Published: 7/30/2024 | Inventor(s): Payman Dehghanian, Shiyuan Wang, Li Li

Keywords(s):

Category(s): Technology Classifications > Industrial or Consumer Tech > Energy Infrastructure and Environment

JobViz: User Interface for Visualization of Majors & Jobs

Invention Summary: University (and industry) career search portals and web-based job search engines allow users to search on many items (e.g., education, location, level, etc.) and then present a text based list of potential job opportunities. University career portals are not as conductive to exploration by job and career searchers as they could...

Published: 9/8/2022 | Inventor(s): Deborah Silver, Li Liu

Keywords(s):

Category(s): Technology Classifications > Software & Copyright, Technology Classifications > Software & Algorithms

Tunable, Anti-Reflection Coating Using Common Shape Memory Polymers

Scalable Nanoparticle Self-Assembly Performs In Ambient ConditionsThis tunable, anti-reflection coating uses a variety of shape memory polymers with a nanoporous structure to help regulate light transmission and reflection in monitors, car dashboards, optical lenses, smart devices, solar cells and more. By 2020, the global anti-reflective coatings market...

Published: 6/27/2021 | Inventor(s): Peng Jiang, Yin Fang, Sin Leo, Danielle Liu

Keywords(s): anti-glare, Antireflection coatings, Nanoparticles, nanoporous surface texture, self-assembly, shape memory polymer, Template Nanostructures

Category(s): Technology Classifications > Engineering > Chemical, Technology Classifications > Engineering > Materials, Technology Classifications > Others > Energy

Distributed Feedback Fiber Laser Pumped by Multimode Diode Lasers

Researchers at the University of Arizona College of Optical Sciences and Canada's Carleton University recently succeeded in fabricating high reflectivity (>99%) Fiber Bragg Gratings (FBGs) into phosphate glass fibers using UV light and a phase mask technique. With this new manufacturing technique, fiber lasers can be created as single monolithic...

Published: 4/3/2023 | Inventor(s): Nasser Peyghambarian, Axel Schülzgen, Li Li, Jacques Albert

Keywords(s):

Category(s): Technology Classifications > Imaging & Optics, Technology Classifications > Imaging & Optics > Lasers & Other Sources

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