Search Results - pd-l1

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Cross Species Single Domain Antibodies Targeting PD-L1 for Treating Solid Tumors
Abstract: Programed Death-Ligand 1 (PD-L1, also known as B7-H1 or CD274) is a cell surface protein that binds to Programmed Cell Death Protein 1 (PD-1, also known as CD279). An imbalance in PD-1/PD-L1 activity contributes to cancer immune escape.  PD-1 is expressed on the surface of antigen-stimulated T cells. The interaction between PD-L1 and PD-1...
Published: 5/14/2025   |   Inventor(s): Mitchell Ho, Glenn Merlino, Dan Li, Hejiao English, Chi-Ping Day
Keywords(s): adoptive cell therapy, Chimeric Antigen Receptor T Cells, HO, ICI, Immune Checkpoint Inhibitor, Immunotherapy, NANOBODY, PD-L1, phage display, Programed Death-Ligand, Single Domain Antibody
Category(s): Collaboration Sought > Collaboration, Application > Therapeutics, Collaboration Sought > Licensing, TherapeuticArea > Oncology
A METHOD OF IDENTIFYING SMALL MOLECULE INHIBITORS FOR PD-1
A METHOD OF IDENTIFYING SMALL MOLECULE INHIBITORS FOR PD-1 Researchers at Stanford, funded in part by the Chan Zuckerberg Biohub, have generated a crystal structure for human PD-1 in complex with one of its ligands, PD-L2, for use in small molecule inhibitor design. Immune checkpoint inhibition of programmed death 1 (PD-1) and its ligand 1 (PD-L1)...
Published: 12/3/2024   |   Inventor(s): Shaogeng Tang, Peter Kim
Keywords(s): Crystal Structure, PD-1, PD-L1, Small Molecule Inhibitor
Category(s): Technology Classifications > Biology, Technology Classifications > Chemistry