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Search Results - dan+li
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High Affinity Nanobodies Targeting B7-H3 (CD276) for Treating Solid Tumors
Abstract: CD276 (also called B7-H3) is a pan-cancer antigen expressed in multiple solid tumors and an emerging cancer target. CD276 protein is overexpressed in pancreatic cancer, prostate cancer, breast cancer, colon cancer, lung cancer, and brain tumors (such as neuroblastoma) – making it an ideal target for cancer therapy. Investigators at the National...
Published: 5/21/2024
|
Inventor(s):
Mitchell Ho
,
Brad St. Croix
,
Ruixue Wang
,
Dan Li
Keywords(s):
ADC
,
Antibody-drug Conjugate
,
B7-H3
,
BREAST CANCER
,
CAR
,
CD276
,
chimeric antigen receptor
,
COLON CANCER
,
Glioma
,
HO
,
lung cancer
,
Nanobodies
,
Neuroblastoma
,
OVARIAN CANCER
,
Pancreatic Cancer
,
solid tumors
Category(s):
Application > Therapeutics
,
Collaboration Sought > Collaboration
,
Collaboration Sought > Licensing
,
TherapeuticArea > Oncology
Combination of recombinant IL-7 with Chimeric Antigen Receptor (CAR) T Cells Targeting Glypican-3 (GPC3) for the Treatment of Hepatocellular Carcinoma (HCC)
Abstract: Hepatocellular carcinoma (HCC) is the most common type of liver cancer. standard treatment for HCC is not suitable for a large proportion of liver cancer patients. As a result, alternative treatments are needed. Chimeric antigen receptor (CAR) T cell therapy is a promising alternative approach selectively targets targeting tumors via tumor-specific...
Published: 5/21/2024
|
Inventor(s):
Mitchell Ho
,
Dan Li
,
Byung Ha Lee
,
Sara Ferrando-Martinez
Keywords(s):
CAR
,
Chimeric Antigen Receptor T Cell Therapy
,
Glypican-3
,
GPC-3
,
HCC
,
hepatocellular carcinoma
,
HO
,
Interleukin-7
,
liver
,
Recombinant IL-7
,
Tumor Specific Antigen
Category(s):
TherapeuticArea > Oncology
,
Collaboration Sought > Collaboration
,
Collaboration Sought > Licensing
,
TherapeuticArea > Immunology
,
Application > Therapeutics
New Chimeric Antigen Receptor (CAR) Format for Developing Improved Adoptive Cell Therapies
Abstract: Adoptive cell therapy (ACT) is an attractive new therapeutic approach for treating various cancers. ACT has recently demonstrated a high degree of efficacy when treating patients with hematological malignancies. However, to date, no effective Chimeric Antigen Receptors (CAR) T cell therapy exists for solid tumors. Researchers in the National...
Published: 5/21/2024
|
Inventor(s):
Mitchell Ho
,
Nan Li
,
Dan Li
Keywords(s):
CANCER
,
chimeric antigen receptor (CAR)
,
GPC2
,
GPC3
,
HO
,
MESOTHELIN
,
solid tumor
,
tumor antigen
Category(s):
Application > Therapeutics
,
Collaboration Sought > Licensing
,
Collaboration Sought > Collaboration
,
TherapeuticArea > Oncology
Cross Species Single Domain Antibodies Targeting PD-L1 for Treating Solid Tumors
Abstract: Programed Death-Ligand 1 (PD-L1, also known as B7-H1 or CD274) is a cell surface protein that binds to Programmed Cell Death Protein 1 (PD-1, also known as CD279). An imbalance in PD-1/PD-L1 activity contributes to cancer immune escape. PD-1 is expressed on the surface of antigen-stimulated T cells. The interaction between PD-L1 and PD-1...
Published: 4/8/2024
|
Inventor(s):
Mitchell Ho
,
Glenn Merlino
,
Dan Li
,
Hejiao English
,
Chi-Ping Day
Keywords(s):
adoptive cell therapy
,
Chimeric Antigen Receptor T Cells
,
HO
,
ICI
,
Immune Checkpoint Inhibitor
,
Immunotherapy
,
NANOBODY
,
PD-L1
,
phage display
,
Programed Death-Ligand
,
Single Domain Antibody
Category(s):
Collaboration Sought > Collaboration
,
Application > Therapeutics
,
Collaboration Sought > Licensing
,
TherapeuticArea > Oncology
PMU-Embedded Analytics for Online Event Detection and Classification in Power Grids
The energy requirement of the world is increasing exponentially every year. With the power demand sites concentrated in the region with the highest population density, energy production sites must be located remotely. This isolation requires lengthy and complicated grids to be designed and manufactured to transmit power over long distances. Grid failures...
Published: 7/30/2024
|
Inventor(s):
Payman Dehghanian
,
Shiyuan Wang
,
Li Li
Keywords(s):
Category(s):
Technology Classifications > Industrial or Consumer Tech > Energy Infrastructure and Environment
Distributed Feedback Fiber Laser Pumped by Multimode Diode Lasers
Researchers at the University of Arizona College of Optical Sciences and Canada's Carleton University recently succeeded in fabricating high reflectivity (>99%) Fiber Bragg Gratings (FBGs) into phosphate glass fibers using UV light and a phase mask technique. With this new manufacturing technique, fiber lasers can be created as single monolithic...
Published: 4/3/2023
|
Inventor(s):
Nasser Peyghambarian
,
Axel Schülzgen
,
Li Li
,
Jacques Albert
Keywords(s):
Category(s):
Technology Classifications > Imaging & Optics
,
Technology Classifications > Imaging & Optics > Lasers & Other Sources
All-Fiber Multicore Fiber Laser Devices
Researchers at the University of Arizona have developed a compact, power-scalable, alignment-free fiber laser that takes a new approach to stabilizing phase-locked operation of multi-core fiber lasers by completely removing all free space optical components. This high-brightness, all-fiber laser package uses passive optical fiber spliced at both ends...
Published: 4/3/2023
|
Inventor(s):
Nasser Peyghambarian
,
Axel Schülzgen
,
Li Li
Keywords(s):
Category(s):
Technology Classifications > Imaging & Optics
,
Technology Classifications > Imaging & Optics > Fiber Optics
,
Technology Classifications > Imaging & Optics > Lasers & Other Sources