Search Results - cancer%2foncology

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Targeted Therapy for Glioblastoma via Purine Metabolism Modulation
NU 2019-086 INVENTORS Atique Ahmed* Cheol Park Jack Shireman SHORT DESCRIPTION This technology introduces a targeted approach for glioblastoma treatment that modulates purine biosynthesis by targeting the ARL13B-IMPDH2 interaction using repurposed FDA-approved and internationally-used drugs. BACKGROUND Glioblastoma is an incurable, aggressive...
Published: 8/5/2025   |   Inventor(s):  
Keywords(s): Cancer/Oncology, Repurposed Drugs, Therapeutics
Category(s): Life Sciences > Therapeutics
Self-powered, bioresorbable drug release systems
NU 2023-045 INVENTORS John Rogers* Colin Franz* Yamin Zhang SHORT DESCRIPTION Northwestern and Shirley Ryan AbilityLab researchers have developed a novel, self-powered, bioresorbable drug delivery system that enables light-controlled, targeted drug release without the need for surgical removal post-treatment. BACKGROUND Current drug delivery systems...
Published: 8/5/2025   |   Inventor(s):  
Keywords(s): Biomaterials, Cancer/Oncology, Drug delivery, Infectious disease, Medical device, Therapeutics
Category(s): Life Sciences > Healthcare Devices, Tools & IT
Improved MEK4 Inhibitors for the Treatment of Cancer
NU 2021-217 INVENTORS Karl Scheidt* Ada Jade Kwong Hidayatullah Munshi Thao Nguyen Pham SHORT DESCRIPTION This technology introduces novel indazole derivatives as potent and selective MEK4 inhibitors for cancer treatment, particularly in advanced prostate cancer and pancreatic adenocarcinoma. The lead molecule is optimized over first-generation...
Published: 8/5/2025   |   Inventor(s):  
Keywords(s): Cancer/Oncology, Pancreatic cancer, Prostate cancer
Category(s): Life Sciences > Therapeutics
Simple Formulation of Anaerobic Bacteria to Treat Solid Tumors
NU 2022-219 INVENTORS Dong-Hyun Kim* Hyunjun Choi Bongseo Choi SHORT DESCRIPTION A formulation of anaerobic bacteria embedded in embolic material, delivered through transcatheter intra-arterial infusion for treating solid tumors. BACKGROUND Non-pathogenic Clostridium novyi (C. novyi-NT) is an anaerobic bacterium capable of selective germination...
Published: 8/5/2025   |   Inventor(s):  
Keywords(s): Cancer/Oncology, Materials, Therapeutics
Category(s): Life Sciences > Therapeutics
Anti-PODXL Antibody for Inhibiting Metastasis in Breast Cancer
NU 2023-110 INVENTORS Huiping Liu* Nurmaa Dashzeveg SHORT DESCRIPTION This technology introduces methods of use for an anti-PODXL antibody that effectively prevents and treats metastasis in breast cancer by inhibiting circulating tumor cell (CTC) cluster formation. BACKGROUND Cancer metastasis is mediated by circulating tumor cells (CTC) and...
Published: 8/5/2025   |   Inventor(s):  
Keywords(s): Breast cancer, Cancer/Oncology
Category(s): Life Sciences > Therapeutics
Advanced Cancer Therapeutic Targeting Removal of H2O2 in Cell Nuclei
NU2023-013 INVENTORS Marcelo Bonini* BACKGROUND Northwestern University Scientists have developed a potential therapeutic to treat advanced stage cancers. It has been shown that in cancer cells, hydrogen peroxide oxidizes histone H3.1. Removal of this hydrogen perioxide from the nucleus of cancer cells with NLS-catalase protected H3.1 was...
Published: 8/5/2025   |   Inventor(s):  
Keywords(s): Cancer/Oncology
Category(s): Life Sciences > Therapeutics
Electrical modulation for the treatment of brain tumors
NU2022-229 INVENTORS Timothy Sita* BACKGROUND Glioblastoma (GBM) is a type of incurable brain tumor with poor prognosis. Despite a combination of treatments, including surgery, radiation, and chemotherapy, most patients do not survive longer than two years following diagnosis. GBM and other types of brain tumors hijack our brain’s...
Published: 8/5/2025   |   Inventor(s):  
Keywords(s): Cancer/Oncology
Category(s): Life Sciences > Therapeutics
CAR T Cells Armored with IL15 for Treating Glioblastoma
NU 2022-074 INVENTORS Irina V. Balyasnikova* BACKGROUND Glioblastoma is a devastating brain cancer for which no effective treatment exists, leading to short patient survival. Although investigations are underway to explore chimeric antigen receptor T (CAR-T) cells as glioblastoma therapy, the immunosuppressive tumor microenvironment (TME)...
Published: 8/5/2025   |   Inventor(s):  
Keywords(s): Cancer/Oncology, Immunology
Category(s): Life Sciences > Therapeutics
New Lipiodol Formulation for Treating Hepatocellular Carcinoma with Transarterial Chemoimmunoembolization
NU 2021-148 INVENTORS Dong Hyun Kim* Heegon Kim SHORT DESCRIPTION A new Lipiodol formulation designed to improve the efficacy and safety of transarterial chemoembolization in combination with immunotherapy. BACKGROUND Transarterial chemoembolization...
Published: 8/5/2025   |   Inventor(s):  
Keywords(s): Cancer/Oncology, Drug delivery, Gastrointestinal and Hepatic disease, Immunology, Immunotherapy, Therapeutics
Category(s): Life Sciences > Therapeutics
Novel Therapeutics for Pediatric Embryonal Tumors Using PLK4 inhibitors
LU 2017-124 INVENTORS Simone T. Sredni* Tadanori Tomita SHORT DESCRIPTION Embryonal tumors such as malignant rhabdoid tumors (MRTs) are aggressive and frequently metastatic embryonal tumors of infancy. However, available therapies often elicit modest anti-tumor response leading to poor survival, or induce highly toxicity in patients of young...
Published: 8/5/2025   |   Inventor(s):  
Keywords(s): Cancer/Oncology, Therapeutics
Category(s): Life Sciences > Therapeutics
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