Search Results - cancer%2foncology

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The use of complex or fusion protein of soluble MIC (Smic) and antibody to treat MIC-negative cancer
NU 2019-146 INVENTORS Jennifer Wu* SHORT DESCRIPTION A fusion protein complex comprising soluble MIC and a non-blocking sMIC-neutralizing antibody that effectively activates CD8 T cells for the treatment of MIC-negative cancer. BACKGROUND Effective T cell co-stimulation is critical for durable tumor control, yet many current immunotherapies...
Published: 12/3/2025   |   Inventor(s):  
Keywords(s): Antibody, Cancer/Oncology, Research tool
Category(s): Life Sciences > Therapeutics
Engineered B-cell Therapy for Cancer Treatment
NU 2022-218 INVENTORS Catalina Lee Chang* Maciej Lesniak* SHORT DESCRIPTION Engineered B cells with reduced expression of key immune checkpoint proteins designed to boost cancer immunotherapy efficacy. BACKGROUND Immunotherapy has transformed cancer treatment; however, its application to brain tumors remains limited by the immunosuppressive...
Published: 12/3/2025   |   Inventor(s):  
Keywords(s): Cancer/Oncology
Category(s): Life Sciences > Therapeutics
New Therapeutic Approach for the Treatment of Acute Myeloid Leukemia
NU 2017-214 Inventors Ali Shilatifard* Zibo Zhao Short Description A new therapeutic approach for the treatment of acute myeloid leukemia using casein kinase inhibitors. Background Leukemia is a group of cancers that affects the bone marrow and results in the overproduction of dysfunctional white blood cells (WBCs). The mixed lineage leukemia...
Published: 11/18/2025   |   Inventor(s):  
Keywords(s): Cancer/Oncology, Therapeutics
Category(s): Life Sciences > Therapeutics
Spherical Nucleic Acids with Sheddable PEG Layers for Enhanced Tumor Targeting
NU 2017-169 INVENTORS Chad Mirkin* (Northwestern University, Weinberg College of Arts and Sciences, Department of Chemistry, Director of the International Institute for Nanotechnology (IIN)) Brian Meckes Wuliang Zhang SHORT DESCRIPTION For oncology applications, this invention offers spherical nucleic acids with an enzyme-cleavable PEG layer...
Published: 11/7/2025   |   Inventor(s):  
Keywords(s): Biologic, Biomarker, Biomedical, Cancer/Oncology, Chemicals, Diagnostics, Drug delivery, Nanoparticle, Nanotechnology, Personalized medicine, Therapeutics
Category(s): Life Sciences > Therapeutics, Life Sciences > Healthcare Devices, Tools & IT, Life Sciences > Biomarkers & Biomedical Research Tools
A Novel Expander for Drug Delivery in Cancer Patients
NU 2022-129 INVENTORS John Yah Sung Kim* Megan Fracol SHORT DESCRIPTION This invention offers a tissue expander that integrates drug delivery for breast reconstruction. It provides gradual inflation while releasing therapeutic agents to support improved healing. BACKGROUND Implant-based breast reconstruction is the most common method following...
Published: 11/6/2025   |   Inventor(s):  
Keywords(s): Cancer/Oncology
Category(s): Life Sciences > Healthcare Devices, Tools & IT
Covalent MEK4 Inhibitors for Targeted Cancer Therapy
NU 2025-154 INVENTORS Karl Scheidt* Gina Connors SHORT DESCRIPTION This technology introduces novel covalent inhibitors of MEK4, built upon previously-developed reversible inhibitors (see NU2019-059 and NU2021-217). A covalent inhibition strategy offers enhanced potency, selectivity, and prolonged duration of action compared to reversible...
Published: 11/6/2025   |   Inventor(s):  
Keywords(s): Cancer/Oncology, Covalent Inhibition, Kinase Inhibitor, MEK4, MEK7
Category(s): Life Sciences > Therapeutics
Clinical Bacterial Isolate Engineered as Prostate Cancer Immunotherapy
NU 2015-087 INVENTORS Praveen Thumbikat* Anthony Schaeffer Jonathan Anker Sarki Abdulkadir SHORT DESCRIPTION This technology uses a genetically modified CP1 E. coli as an immunotherapeutic agent for prostate cancer. It offers a non-invasive treatment option designed to stimulate an immune response in both early stage and advanced disease. BACKGROUND Existing...
Published: 11/6/2025   |   Inventor(s):  
Keywords(s): Cancer/Oncology, Therapeutics
Category(s): Life Sciences > Therapeutics
Nanocytological and Molecular Analysis of Fecal Colonocytes for Colon Cancer Screening
NU 2010-131 INVENTORS Vadim Backman* Dhwanil Damania Dhananjay Kunte Hariharan Subramanian Hemant Roy Mart De La Cruz SHORT DESCRIPTION This technology offers a novel fecal test that detects nanoarchitectural and molecular markers in colonocytes. It delivers a minimally invasive screening method for early detection of colon cancer. BACKGROUND Colorectal...
Published: 11/6/2025   |   Inventor(s):  
Keywords(s): Cancer/Oncology, Colon cancer, Diagnostics, Drug screening, Imaging, Research tool
Category(s): Life Sciences > Biomarkers & Biomedical Research Tools
Targeted Therapy for Glioblastoma via Purine Metabolism Modulation
NU 2019-086 INVENTORS Atique Ahmed* Cheol Park Jack Shireman SHORT DESCRIPTION This technology introduces a targeted approach for glioblastoma treatment that modulates purine biosynthesis by targeting the ARL13B-IMPDH2 interaction using repurposed FDA-approved and internationally-used drugs. BACKGROUND Glioblastoma is an incurable, aggressive...
Published: 11/6/2025   |   Inventor(s):  
Keywords(s): Cancer/Oncology, Repurposed Drugs, Therapeutics
Category(s): Life Sciences > Therapeutics
Self-powered, bioresorbable drug release systems
NU 2023-045 INVENTORS John Rogers* Colin Franz* Yamin Zhang SHORT DESCRIPTION Northwestern and Shirley Ryan AbilityLab researchers have developed a novel, self-powered, bioresorbable drug delivery system that enables light-controlled, targeted drug release without the need for surgical removal post-treatment. BACKGROUND Current drug delivery systems...
Published: 11/6/2025   |   Inventor(s):  
Keywords(s): Biomaterials, Cancer/Oncology, Drug delivery, Infectious disease, Medical device, Therapeutics
Category(s): Life Sciences > Healthcare Devices, Tools & IT
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