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Efficient production and delivery of bioactive peptides via Gram-negative bacterial secretion system
Engineered Gram-negative bacteria use the microcin V secretion system to produce and release various active peptides efficiently. This versatile tech­nology works across multiple bacterial species and preserves peptide functionality for research and therapeutic uses. Background The production and secretion of bioactive peptides are critical in...
Published: 1/9/2025   |   Inventor(s): Bryan Davies, Sun-Young Kim, Jennifer Parker
Keywords(s):  
Category(s): Life sciences > Therapeutics > Biologic, Life sciences > Therapeutics > Synthetic biology
Immobilizing enzymes by crosslinking biomolecular condensates
​ Proposed method for immobilizing enzymes by engineering enzyme-RGG fusion proteins, inducing phase separation into biomolecular condensates, and cross-linking condensates. Invention Summary: Enzyme immobilization techniques for industrial use often impede the effectiveness of the biocatalyst. A promising alternative method involves utilizing...
Published: 1/9/2025   |   Inventor(s): Augene Park, Benjamin Schuster
Keywords(s):  
Category(s): Technology Classifications > Physical Sciences & Engineering
TauSeeK: Disease Specific Tau Protein Fibrils & Seeding Proteins
NU2024-139 INVENTORS Austin Dubose Michael Vigers Andrew Longhini Vishnu Vijayan Kenneth Kosik Sam Lobo Peter C. Ryffel Songi Han* SHORT DESCRIPTION Compositions, kits, and methods for generating synthetic miniature tau peptides and fibrils, and synthetic full-length pathogenic tau fibrils. BACKGROUND A major hallmark of several neurodegenerative...
Published: 1/9/2025   |   Inventor(s):  
Keywords(s): Neurodegenerative disease, Research tool, Synthetic biology
Category(s): Life Sciences > Therapeutics
StarTrace: A Multiplex Drug Testing Platform for Personalized Medicine
Reference #: 1744 The University of South Carolina is offering licensing opportunities for StarTrace: A Multiplex Drug Testing Platform for Personalized Medicine Background: The development of cancer treatments tailored to the needs of individual patients is a promising paradigm for oncology. Increased utilization of tumor sequencing illustrates...
Published: 1/9/2025   |   Inventor(s): Phillip Buckhaults, Sana Khalili, Shrey Patel, Carolyn Banister
Keywords(s):  
Category(s): Health Sciences, Software and Computing
Biosynthesized halogenated tryptophan derivatives
A new E. coli-based system uses metabolic engineering and co-cultures to produce various halogenated tryptophan molecules from glucose, providing an environmentally friendly alternative for creating diverse compounds used in pharmaceuticals and other industries. Background Halogenated molecules are critical to various industries, including pharma­ceuticals,...
Published: 1/9/2025   |   Inventor(s): Hal Alper, Kevin Reed, Sierra Brooks
Keywords(s):  
Category(s): Life sciences > Therapeutics > Synthetic biology, Life sciences > Agriculture
Method for Repurposing FDA-approved Therapeutics & Composition for Treating Mesothelioma
The amount of time and money that goes into getting a drug from initial discovery to FDA approval is substantial, typically involving at least 10 years and hundreds of millions of dollars. Because of this, there has been a growing interest in repurposing drugs which have previously been approved for human use, particularly since their MOA as well as...
Published: 1/8/2025   |   Inventor(s): Chris Plaisier, Sierra Wilferd, Choung Hoang
Keywords(s): Cancer, Drug, Drug Discovery
Category(s): Pharmaceuticals, Cancer, Cancer Therapeutics, Artificial Intelligence/Machine Learning, Computing & Information Technology, Life Science (All LS Techs)
Modified Simmons Catheter
​ ​ Neurointerventions with improved success Invention Summary: The global neurovascular catheter market size was valued at USD 2.88 billion in 2020 and is expected to expand at a compound annual growth rate of 6.7% from 2021 to 2028. Neurointerventionalists, interventional radiologists, cardiologists, and vascular surgeons often can have...
Published: 1/8/2025   |   Inventor(s): Amit Singla
Keywords(s): Neurological disorder & neuropathic pain
Category(s): Technology Classifications > Diagnostics, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Medical Devices
Antibacterial Coagulating Gel Spray
Blood loss and infections are a major cause of concern and death for traumatic injuries and wounds. It is estimated that blood loss accounts for more than 35% of all prehospital deaths in trauma patients. Thus, it is imperative that bleeding is stopped quickly and at the point of care. While there are many products to staunch bleeding, including gauze...
Published: 1/8/2025   |   Inventor(s): Emily Byrne, Grace Billingsley, Tran Nguyen, Alfonso Gomez-De Leon, Oscar Voeller, Sarah Stabenfeldt, Jessica Weaver
Keywords(s):  
Category(s): Advanced Materials/Nanotechnology, Biomaterials, Life Science (All LS Techs), Medical Devices
Selective Modulators of Ah-R to Treat Cancer
Synergistic compositions and method of using modulators of Ah-R activity and synergistic compounds to treat cancer Background Aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor. When activated by the binding of a wide range of both endogenous and exogenous small molecules, AhR signaling influences cellular outcomes in different...
Published: 1/8/2025   |   Inventor(s): Siva Kolluri, Bach Nguyen, Daniel Elson
Keywords(s):  
Category(s): Therapeutics
Pharmaceutical manufacturing of the future: a continuous 3D printing approach for personalized medicine
Background Driven by personalized medicine, 3D printing has emerged as a promising technology for creating tailored pharma­ceutical dosage forms. One of its methods, Fused Deposition Modeling (FDM), is particularly notable for its ability to produce complex geometries using thermoplastic polymers. However, current FDM processes face significant...
Published: 1/8/2025   |   Inventor(s): Mohammed Maniruzzaman, Vineet Kulkarni, Faez Alkadi
Keywords(s):  
Category(s): Life sciences > Therapeutics > Manufacturing platform
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