Netrin-1 Mimetic Peptide Amphiphile Assemblies
NU 2024-174 INVENTORS
SHORT DESCRIPTION
Nanofiber-shaped supramolecular assemblies that mimic netrin-1 bioactivity to stimulate neurite growth and synaptic maturation for enhanced CNS regeneration. BACKGROUND
Neurotrophic factors are essential for the development and regeneration of neurons; however, injuries in the central nervous system create inhibitory environments that limit natural recovery. Conventional therapeutic approaches with native netrin-1 are challenged by short half-lives and high dosage requirements, calling for innovative biomimetic solutions. ABSTRACT
This invention details the development of a nanofiber-shaped supramolecular mimetic of netrin-1 where peptide amphiphiles incorporate a cyclic peptide sequence to activate the DCC receptor. Through a combination of imaging and computational analysis, the fibrous assembly has been shown to enhance neurite outgrowth, synaptic protein expression, and electrical activity in primary cortical neurons at low monomer ratios. By addressing the limitations of native netrin-1 therapies, these supramolecular nanostructures offer a promising platform for treating CNS injuries. Their integration into hydrogel systems further broadens potential applications in regenerative therapies for spinal cord injuries, stroke, peripheral nerve injuries, and neurodegenerative diseases. APPLICATIONS
ADVANTAGES
PUBLICATIONS
IP STATUS
US Patent Pending