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Search Results - zheng-gang+liu
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Humanized Monoclonal Antibodies Specific Against Human Soluble Tissue Factor (hsTF) as Diagnosis, Prevention and Therapeutic Agents for Thrombosis
Summary: The National Cancer Institute (NCI) seeks research co-development partners and/or licensees for a novel humanized monoclonal antibody (58B3) that selectively targets a newly identified soluble Tissue Factor (sTF) to diagnose, prevent and treat pathological thrombosis associated with inflammation, viral/bacterial infection, sepsis and cancer...
Published: 9/29/2025
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Inventor(s):
Zheng-gang Liu
,
Swati Choksi
,
PeiXing Wan
Keywords(s):
Category(s):
Collaboration Sought > Collaboration
,
Collaboration Sought > Licensing
,
TherapeuticArea > Immunology
,
TherapeuticArea > Infectious Disease
,
TherapeuticArea > Oncology
,
Application > Diagnostics
,
Application > Therapeutics
M4 Foldamer Peptidomimetic: Targeting Amyloid-beta (Aβ) Aggregation to Restore Neuronal Function in Alzheimer’s Disease
Adantages Enhanced Blood-Brain Barrier (BBB) Penetration allows for efficient therapeutic targeting Superior serum stability enables a longer therapeutic window compared to conventional peptide therapeutics Multimodal therapeutic mechanism simultaneously addresses multiple pathological hallmarks of Alzheimer’s Disease (AD) Summary Alzheimer’s...
Published: 9/29/2025
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Inventor(s):
Jianfeng Cai
,
Heng Liu
,
Donghui Zhu
,
Firoz Akhter
Keywords(s):
Alzheimer's Disease
,
Neurodegenerative Diseases
,
Therapeutics
Category(s):
zzNeurodegenerative Diseases Treatment
,
Technology Classifications > Medical > Neuroscience
,
Technology Classifications > Medical > Therapeutics
Novel Helical Peptodomimetics that Prevent the Formation of Aβ Oligomerization in Alzheimer’s Disease (AD)
Advantages: Developed sulfonyl-γ-AA peptide helical peptidomimetics that can prevent the formation of neurotoxic Aβ oligomerization. High Specificity: The lead sulfonyl-γ-AApeptide helical foldamer, Ab-6, exhibits precise targeting to the central region of Aβ42 and induces α-helix conformation in Aβ. Sequence-Specific...
Published: 9/10/2025
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Inventor(s):
Jianfeng Cai
,
Heng Liu
Keywords(s):
Alzheimer's Disease
,
Biotechnology
,
Neurodegenerative Diseases
Category(s):
Technology Classifications > Medical > Biomedical Engineering
,
Technology Classifications > Medical > Biotechnology
,
Technology Classifications > Medical > Neuroscience
DNA Methylation Barriers
In normal differentiated cells, most of the genome is densely methylated, except CpG islands near promoters of actively transcribed genes. Maintaining this boundary between unmethylated promoter-associated and adjacent methylated regions is crucial as loss of segregation can lead to disease. Unfortunately, it is not clear where these boundaries are,...
Published: 2/13/2025
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Inventor(s):
Li Liu
,
Jingmin Shu
Keywords(s):
Category(s):
Applied Technologies
,
Genomic Assays/Reagents/Tools
,
Life Science (All LS Techs)
,
Diagnostic Assays/Devices
PMU-Embedded Analytics for Online Event Detection and Classification in Power Grids
The energy requirement of the world is increasing exponentially every year. With the power demand sites concentrated in the region with the highest population density, energy production sites must be located remotely. This isolation requires lengthy and complicated grids to be designed and manufactured to transmit power over long distances. Grid failures...
Published: 9/12/2025
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Inventor(s):
Payman Dehghanian
,
Shiyuan Wang
,
Li Li
Keywords(s):
Category(s):
Technology Classifications > Industrial or Consumer Tech > Energy Infrastructure and Environment
Design of Semi-Transparent, Transparent, Stacked or Top-Illuminated Organic Photovoltaic Devices
Case 2012-792UCLA researchers in the Department of Materials Science and Engineering have developed novel tandem transparent and semi-transparent organic photovoltaic (OPV) devices.BACKGROUNDSolar cell technologies are the most effective method to produce clean energy at a low cost with minimal pollution. Transparent or semi-transparent solar cells...
Published: 7/17/2025
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Inventor(s):
Gang Li
,
Yang Yang
,
Chun Chao Chen
,
Letian Dou
,
Rui Zhu
Keywords(s):
Electronics & Semiconductors
,
Energy & Water
Category(s):
Electrical > Electronics & Semiconductors
,
Energy & Environment > Energy Generation > Solar
,
Materials > Fabrication Technologies
Tadpole Endoscope
Published: 5/31/2017
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Inventor(s):
Ruxu Du
,
Zheng Li
,
Jao Yiu Joseph Sung
Keywords(s):
Category(s):
Medical Devices
,
Mechanical & Automation Engineering
A bioadhesive, mechanically robust and injectable hydrogel for biomedical applications
[Licensing negotiation in progress] [Invitation for Expression of Interest- Deadline 30 March 2021] We are inviting expressions of interest (EoI) for commercializing “A Bioadhesive, Mechanically Robust and Injectable Hydrogel for Biomedical Applications” technology. The innovation is developed by Professor BIAN Liming, Department...
Published: 9/16/2024
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Inventor(s):
Liming BIAN
,
Qian Feng
,
Kongchang Wei
,
Gang Li
,
Sien Li
Keywords(s):
Category(s):
Chemistry & Material Science
,
Medical Devices
Distributed Feedback Fiber Laser Pumped by Multimode Diode Lasers
Researchers at the University of Arizona College of Optical Sciences and Canada's Carleton University recently succeeded in fabricating high reflectivity (>99%) Fiber Bragg Gratings (FBGs) into phosphate glass fibers using UV light and a phase mask technique. With this new manufacturing technique, fiber lasers can be created as single monolithic...
Published: 4/3/2023
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Inventor(s):
Nasser Peyghambarian
,
Axel Schülzgen
,
Li Li
,
Jacques Albert
Keywords(s):
Category(s):
Technology Classifications > Imaging & Optics
,
Technology Classifications > Imaging & Optics > Lasers & Other Sources
Immortalized Human Mesenchymal Stem Cell Line Overexpressing Thymidine Kinase Gene
Invetion Reference: 11/MED/454 There are over 10 million new cases of cancer every year. To fight this global health challenges, new treatment approaches, besides traditional strategies like chemotherapy and radiotherapy, are urged. Gene therapy is one of the promising approaches, but a safe and efficient delivery method to tumor site is necessary...
Published: 1/20/2019
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Inventor(s):
Gang Li
,
Yuk Wai Lee
,
Po Ying Lau
Keywords(s):
Stem Cell
Category(s):
Therapeutics
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