Search Results - yucheng+zhang

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Miniaturized Solid-State Metal Additive Manufacturing Tooling and Design
THE CHALLENGE The main challenge with current friction-based, solid-state metal additive manufacturing methods—like traditional Additive Friction Stir Deposition (AFSD)—lies in their reliance on bulky equipment, large feedstock rods, and high-force machinery, which limits flexibility, increases costs, and restricts use to factory settings....
Published: 7/3/2025   |   Inventor(s): Ryan Gottwald, Hang Yu
Keywords(s):  
Category(s): Technology Classifications > Chemicals/Materials
Modified Aluminum Alloys for High-Strain Applications
THE CHALLENGE The key challenge in advancing high-strength aluminum alloys like the 7xxx and 6xxx series lies in bridging the gap between their exceptional mechanical potential and the limitations of current manufacturing methods. While industries such as aerospace and automotive demand lightweight materials with high strength and durability, existing...
Published: 7/3/2025   |   Inventor(s): Jake Yoder, Greg Hahn, Hang Yu
Keywords(s):  
Category(s): Technology Classifications > Chemicals/Materials
High-Potency Biased β2-adrenergic Receptor Agonist for Treating Respiratory Diseases
Advantages Ultra-potent β2-adrenergic receptor agonist that stimulates cAMP production with sub-nanomolar potency (EC50 = 0.25nM) Biased signaling profile selectively activates Gαs-mediated cAMP signaling while avoiding β-arrestin2 recruitment, reducing receptor desensitization characteristic of traditional treatments such as albuterol Maintains...
Published: 5/27/2025   |   Inventor(s): Stephen Liggett, Donghwa Kim, Yu Chen, Jesper Madsen, Steven An
Keywords(s): Pharmaceuticals, Respiratory Diseases Treatment
Category(s): Technology Classifications > Medical > Respiratory, Technology Classifications > Medical > Therapeutics, Technology Classifications > Medical > Pharmaceuticals
Multi-material electrospinning system for 3D-printed fiber architectures
Background Electrospinning and additive manufacturing have become increasingly important in fields such as biotechnology, pharmaceuticals, and tissue engineering, where there is growing demand for complex fiber architectures and multifunctional material systems. However, traditional electrospinning methods struggle to meet the precision, scalability,...
Published: 4/25/2025   |   Inventor(s): Mohammed Maniruzzaman, Yu Zhang, Faez Alkadi, Ishaan Duggal
Keywords(s):  
Category(s): Life sciences > Therapeutics > Manufacturing platform
Advanced multi-channel controlled pneumatic printheads for 3D printing and particle fabrication
MAGIC printheads are customizable multi-channel pneumatic systems for 3D printing that create precise pharmaceutical and biological micro-particles. They enable controlled mixing and extrusion, accommodate various materials, and enhance drug delivery and biomedical applications. Background Producing micro- and nanoparticles for pharmaceutical and...
Published: 2/20/2025   |   Inventor(s): Mohammed Maniruzzaman, Yu Zhang, Faez Alkadi
Keywords(s):  
Category(s): Life sciences > Therapeutics > Manufacturing platform
Safe Explicable Robot Planning
Background Effective human-robot interaction must be informed by human expectations and knowledge of the world, including how robots are expected to act/interact in various situations. However, knowledge about the robot may be inconsistent with the ground truth, which can result in the robot not meeting expectations, and the interaction integrity being...
Published: 2/13/2025   |   Inventor(s): Yu Zhang, Akkamahadevi Hanni, Andrew Boateng
Keywords(s):  
Category(s): Physical Science, Applied Technologies, Wireless & Networking, Artificial Intelligence/Machine Learning
3D-printed biosensors for high-sensitivity molecular detection
This invention describes the creation of highly sensitive biosensors through 3D printing using stereolithography (SLA). These biosensors, made from a biopolymer blend with specific monomers and a photoinitiator, are functionalized with recognition molecules to detect small and large analytes, including disease markers, in commercial well plates. Background Additive...
Published: 7/26/2024   |   Inventor(s): Mohammed Maniruzzaman, Yu Zhang
Keywords(s):  
Category(s): Life sciences > Research tools > Tool/assay/screening platform, Life sciences > Diagnostic
“Bio-Flex”: advanced formulation for sustainable stereolithography (SLA)
Background/problem Stereolithography (SLA) 3D printing has transformed the biomedical field with creation of highly accurate, patient-specific medical devices such as tissue scaffolds, implants, and surgical tools. This technology leverages computer-aided design and medical imaging data to produce structures with precise geometries at submicron scales....
Published: 7/26/2024   |   Inventor(s): Mohammed Maniruzzaman, Yu Zhang, Anqi Lu
Keywords(s):  
Category(s): Life sciences > Medical technology > Medical devices, Life sciences > Therapeutics > Drug delivery
Novel Small Molecule Inhibitors Targeting Clostridioides Difficile Sporulation
­Advantages: The development of DBO compounds represents a novel therapeutic approach to tackling CDI. By inhibiting C. difficile sporulation, DBO compounds address a major cause of CDI recurrence, reducing the likelihood of patients experiencing repeated infections. DBO compounds improve the effectiveness of existing antibiotics used to treat...
Published: 10/2/2023   |   Inventor(s): Yu Chen, Michael Sacco, James Leahy, Elena Bray, Xingmin Sun, Xiujun Zhang
Keywords(s): Drug Discovery, Infectious Diseases Treatment
Category(s): Technology Classifications > Medical > Therapeutics, Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical > Medical Diagnostics, Technology Classifications > Medical > Infectious Diseases, Technology Classifications > Medical > Biotechnology
Thermal Control During Additive Manufacturing
THE CHALLENGE Additive manufacturing (AM) has emerged as a powerful tool within engineering. Many AM and coating processes rely on thermal input to soften or melt the materials involved in processing. However, this melting or softening typically results in a higher thermal gradient between deposited material and the workpiece, commonly resulting in...
Published: 6/26/2025   |   Inventor(s): Robert Griffiths, David Garcia, Hang Yu
Keywords(s):  
Category(s): EXPERIMENT--DO NOT USE, Technology Classifications > Additive Manufacturing
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