Search Results - xianglan+yao

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Tumor-pH–Triggered Doxorubicin Prodrug with On-Demand Shelf-Stable Precursor
This invention introduces a small-molecule doxorubicin prodrug that remains inert in blood and rapidly activates in the mildly acidic tumor microenvironment. Featuring a shelf-stable maleimide pre-prodrug that converts on demand to the ultra-acid-labile DMA form, it enables targeted chemotherapy with improved selectivity, scalable synthesis, and reduced...
Published: 11/12/2025   |   Inventor(s): Ming An, Lan Yao, Vladyslav Nazarenko
Keywords(s): Technologies
Category(s): Campus > Binghamton University
Endothelium-Specific Laminin Reporter Mouse Line Laminin-mCherry/eGFP+/–; Cdh5-CreER+/– Mouse Line
Advantages Enables endothelial-specific labeling of laminin-γ1 in vivo. Tamoxifen-inducible system allows temporal control of recombination. Dual-color fluorescence distinguishes target cell-derived laminin from other cell-derived laminin. Co-localization with laminin-γ1 antibody confirms biological fidelity. Facilitates mapping...
Published: 11/25/2025   |   Inventor(s): Yao Yao
Keywords(s): Animal Models, Research Tools
Category(s): Technology Classifications > Research Tools/Copyright > Animal Models
Novel Laminin Reporter Mouse Line for in vivo Imaging and Laminin Biology Research (Laminin-mCherry/eGFP+/-) Pre-Cre
Advantages First-ever dual-color laminin reporter mouse line. Enables visualization of laminin-γ1 expression in vivo with high fidelity. mCherry signal replicates endogenous laminin distribution without Cre activation. No background eGFP signal ensures clean baseline imaging. Targets the widely expressed γ1 subunit, enhancing...
Published: 10/9/2025   |   Inventor(s): Yao Yao
Keywords(s): Animal Models, Neuroscience, Research Tools
Category(s): Technology Classifications > Research Tools/Copyright > Animal Models
Cycioxygenase-2 Inhibition for the Treatment-SAA-high Asthma
This technology includes the use of cyclooxygenase-2 (COX-2) inhibitors for the treatment of serum amyloid A (SAA)-high asthma. A commercially available enzyme-linked immunosorbent assay was used to analyze serum levels of SAA in a cohort of 154 non-asthmatic subjects to establish the upper 95th centile value of serum SAA in healthy individuals as >...
Published: 9/11/2024   |   Inventor(s): Stewart Levine, Xianglan Yao, Alan Remaley, Amisha Barochia, Maryann Kaler
Keywords(s):  
Category(s): Application > Diagnostics, Application > Therapeutics, Collaboration Sought > Licensing, TherapeuticArea > Immunology, TherapeuticArea > Respiratory