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Diagnosis of hypertrophic cardiomyopathy and left ventricular hypertrophy using frequency domain analysis of ECG signals
Background Cardiac conditions involving abnormal thickening of the heart muscle, such as hypertrophic cardiomyopathy (HCM) and left ventricular hypertrophy (LVH), present significant diagnostic challenges due to their overlapping symptoms and similar manifestations in standard ECG readings. Existing diagnostic methods—including echocardiograms,...
Published: 5/19/2025   |   Inventor(s): Dongmei Chen, Edward Kim, Wei Li
Keywords(s):  
Category(s): Computer > Algorithms and software methods > Healthcare, Computer > Algorithms and software methods
Reconfigurable RF/Digital Hybrid 3D Interconnect
­A novel interconnect technology that enables system designers to take better advantage of increased IC power while satisfying energy consumption and space limitations. Background: As the semiconductor industry develops technologies on the nano-scale, interconnect latency is increasing. This places serious limitations on designs, as the input/output...
Published: 5/13/2025   |   Inventor(s): Robert Geer, Wei Wang, Tong Jing
Keywords(s): Technologies
Category(s): Campus > SUNY Polytechnic Institute, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Imaging, Technology Classifications > Medical Imaging, Technology Classifications > Optics and Photonics, Technology Classifications > Research Tools and Reagents
Suppressive Molecules of Diseases with Altered IgE Regulation
Provides a new platform for the development of diseases associated with abnormal regulation of immunoglobulin E (IgE). Background: Previous research has demonstrated that congeners of tetracycline, minocycline, and doxycycline suppress asthmatic symptoms in vivo, and immunoglobulin E (IgE) from asthmatics in vitro in a dose-dependent manner. In theory,...
Published: 5/13/2025   |   Inventor(s): Helen Durkin (Deceased), Martin Bluth, Rauno Joks, Tamar Smith-Norowitz
Keywords(s): allergy, asthma, atopy, immunoglobulin E (IgE)
Category(s): Campus > SUNY Downstate Health Sciences University, Technology Classifications > Biomedical Science and Engineering
Washable SERS Fabrics via Micro-Imprinting
THE CHALLENGE The major challenge in wearable SERS (Surface-Enhanced Raman Spectroscopy) sensors lies in bridging the gap between cutting-edge lab technology and real-world usability. While SERS offers powerful, label-free chemical detection at the molecular level, current fabrication methods rely on expensive clean-room processes, rigid substrates,...
Published: 5/9/2025   |   Inventor(s): Aditya Garg, Wei Zhou
Keywords(s):  
Category(s): Technology Classifications > Engineering, Technology Classifications > Biomedical
Fast Viral Detection via SERS and Machine Learning
THE CHALLENGE The key challenge in developing effective virus detection tools for real-world environments lies in bridging the gap between laboratory-grade accuracy and field-ready usability. Current diagnostic methods like PCR and immunoassay are highly sensitive but depend on complex sample preparation, costly reagents, cold-chain logistics, and...
Published: 5/5/2025   |   Inventor(s): Aditya Garg, Wei Zhou, Peter Vikesland, Linsey Marr, Nisha Duggal
Keywords(s):  
Category(s): Technology Classifications > Biomedical, Technology Classifications > Engineering
Photoelastic Polymer Sensor
Executive Summary Sensors for measuring force or pressure are used in a wide variety of applications in industrial, healthcare and automation. Soft sensors, in particular, are used in applications where only low levels of stress are measured. However, one drawback with current soft sensors, is the long term repeatability and cost. Researchers at Michigan...
Published: 4/22/2025   |   Inventor(s): Jiabin Liu, Shaoting Lin, Wei Li
Keywords(s):  
Category(s): Advanced Materials, Devices, Test and Measurement
Targeted, Enhanced Modification Of Lipid NanoparticlesTto Improve Tumor Therapeutic Efficacy
A method to inhibit small extracellular vesicles (sEVs) released by tumor cells to enhance lipid nanoparticle (LNP) accumulation in tumors. Problem: Lipid nanoparticles (LNPs) have shown promise as drug delivery systems for various diseases with several clinically approved products. However, their ability to deliver genes specifically to tumor cells...
Published: 4/11/2025   |   Inventor(s): Michael Mitchell, Ningqiang Gong, Wenqun Zhong, Wei Guo
Keywords(s): Bioengineering, Drug Delivery, Immunoncology, Oncology
Category(s): Technology Classifications > Therapeutics
Monofunctional MDM2 Degraders for Disease Treatment
This invention is for a novel class of MDM2 degraders for treatment of acute myeloid leukemia (AML) and other cancers. This new therapeutic avenue leverages promote ubiquitination of the molecule-MDM2 complex to induce self-degradation in tumors. Background: The American Cancer Society’s estimates for acute myeloid leukemia (AML) in the United...
Published: 3/24/2025   |   Inventor(s): Wei Wang, Jennifer Carew, Steffan Nawrocki, Mengyang Chang, Fangchao Bi
Keywords(s):  
Category(s): Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Life Sciences > Small Molecules
Sensitive Point-of-Care miRNA Detection Using a One-Pot, Isothermal Assay
Rapid, RNA Extraction-Free Detection of miRNAs Biomarkers for Accurate Cancer Diagnosis and Prognosis This CRISPR-Cas12a-based assay allows for the rapid, sensitive detection of microRNAs using a one-pot, isothermal process. MicroRNAs(miRNAs) are endogenous and short, non-coding single-stranded RNAs. They participate in various biological functions...
Published: 5/30/2025   |   Inventor(s): Yong Zeng, He Yan
Keywords(s):  
Category(s): Technology Classifications > Human Health Care > Diagnostics, Technology Classifications > Veterinary > Diagnostics
Dual-Functional Tetrazine Reagents for Bis-Thiol Bioconjugation and Functionalization
This method is for a novel dual-functional tetrazine reagent with application in Cys-specific bioconjugation and functionalization of target proteins. This class of compounds can be utilized for specific bis-thiol targeting. Background: Bioconjugates are molecules with altered chemical structures via substrates or reagents that allows for biomolecule...
Published: 2/18/2025   |   Inventor(s): Wei Wang
Keywords(s):  
Category(s): Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Healthcare Portfolios, Technology Classifications > Research Tools > Reagents
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