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Search Results - wei+(helena)+he
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Targeted, Enhanced Modification Of Lipid NanoparticlesTto Improve Tumor Therapeutic Efficacy
A method to inhibit small extracellular vesicles (sEVs) released by tumor cells to enhance lipid nanoparticle (LNP) accumulation in tumors. Problem: Lipid nanoparticles (LNPs) have shown promise as drug delivery systems for various diseases with several clinically approved products. However, their ability to deliver genes specifically to tumor cells...
Published: 4/11/2025
|
Inventor(s):
Michael Mitchell
,
Ningqiang Gong
,
Wenqun Zhong
,
Wei Guo
Keywords(s):
Bioengineering
,
Drug Delivery
,
Immunoncology
,
Oncology
Category(s):
Technology Classifications > Therapeutics
Reconfigurable RF/Digital Hybrid 3D Interconnect
A novel interconnect technology that enables system designers to take better advantage of increased IC power while satisfying energy consumption and space limitations. Background: As the semiconductor industry develops technologies on the nano-scale, interconnect latency is increasing. This places serious limitations on designs, as the input/output...
Published: 4/1/2025
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Inventor(s):
Robert Geer
,
Wei Wang
,
Tong Jing
Keywords(s):
Technologies
Category(s):
Campus > SUNY Polytechnic Institute
,
Technology Classifications > Biomedical Science and Engineering
,
Technology Classifications > Imaging
,
Technology Classifications > Medical Imaging
,
Technology Classifications > Optics and Photonics
,
Technology Classifications > Research Tools and Reagents
Monofunctional MDM2 Degraders for Disease Treatment
This invention is for a novel class of MDM2 degraders for treatment of acute myeloid leukemia (AML) and other cancers. This new therapeutic avenue leverages promote ubiquitination of the molecule-MDM2 complex to induce self-degradation in tumors. Background: The American Cancer Society’s estimates for acute myeloid leukemia (AML) in the United...
Published: 3/24/2025
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Inventor(s):
Wei Wang
,
Jennifer Carew
,
Steffan Nawrocki
,
Mengyang Chang
,
Fangchao Bi
Keywords(s):
Category(s):
Technology Classifications > Healthcare Portfolios > Oncology
,
Technology Classifications > Life Sciences > Small Molecules
Sensitive Point-of-Care miRNA Detection Using a One-Pot, Isothermal Assay
Rapid, RNA Extraction-Free Detection of miRNAs Biomarkers for Accurate Cancer Diagnosis and Prognosis This CRISPR-Cas12a-based assay allows for the rapid, sensitive detection of microRNAs using a one-pot, isothermal process. MicroRNAs(miRNAs) are endogenous and short, non-coding single-stranded RNAs. They participate in various biological functions...
Published: 3/4/2025
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Inventor(s):
Yong Zeng
,
He Yan
Keywords(s):
Category(s):
Technology Classifications > Human Health Care > Diagnostics
,
Technology Classifications > Veterinary > Diagnostics
Dual-Functional Tetrazine Reagents for Bis-Thiol Bioconjugation and Functionalization
This method is for a novel dual-functional tetrazine reagent with application in Cys-specific bioconjugation and functionalization of target proteins. This class of compounds can be utilized for specific bis-thiol targeting. Background: Bioconjugates are molecules with altered chemical structures via substrates or reagents that allows for biomolecule...
Published: 2/18/2025
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Inventor(s):
Wei Wang
Keywords(s):
Category(s):
Technology Classifications > Life Sciences > Small Molecules
,
Technology Classifications > Healthcare Portfolios
,
Technology Classifications > Research Tools > Reagents
Dual Performing Vinyl-tetrazine for Rapid, Selective Bioconjugation and Functionalization of Cysteine Proteins
This method is for a novel dual-functional tetrazine reagent with application in Cys-specific bioconjugation and functionalization of target proteins. This class of compounds can be utilized for specific single-thiol targeting. This novel method possesses an electron withdrawing tetrazine substituted vinyl moiety that exists as a Michael receptor for...
Published: 2/17/2025
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Inventor(s):
Wei Wang
Keywords(s):
Category(s):
Technology Classifications > Life Sciences > Small Molecules
,
Technology Classifications > Healthcare Portfolios
,
Technology Classifications > Research Tools > Reagents
Use of MRS to Identify Chronic Injury Post-Stroke
This invention involves using magnetic resonance spectroscopy (MRS) to identify lipid-laden foam cells to diagnose a chronic stroke injury. This technology is specifically meant for monitoring patients post-stroke brain injury. This largely relates to improving management patient care and advancing stroke therapeutics. Background: Currently, MRS...
Published: 2/10/2025
|
Inventor(s):
Helena Morrison
,
Theodore Trouard
Keywords(s):
Category(s):
Technology Classifications > Healthcare Portfolios > Neurology
,
Technology Classifications > Life Sciences > Diagnostics
Chip-integrated Nanolaminate Nano-optoelectrode Arrays for Interfacial Electrochemical Reaction Monitoring
THE CHALLENGE: In the field of electrochemistry, understanding the dynamics of interfacial reactions is crucial for advancements in areas such as electrocatalysis, biosensing, and energy conversion. Real-time monitoring of these reactions allows scientists to gain insights into mechanisms that drive these processes. Accurate and detailed analysis of...
Published: 4/2/2025
|
Inventor(s):
Yuming Zhao
,
Chuan Xiao
,
Wei Zhou
Keywords(s):
Category(s):
Technology Classifications > Chemicals/Materials
Acquisition – Software to Control Acquisition of Images for Near-Earth Object Survey Operations
The Acquisition subsystem in the Catalina Sky Survey (CSS) software suite manages the operation of telescopes and instruments to capture data on asteroids and Near-Earth Objects (NEOs). Once areas of the sky are selected for observation, Acquisition takes over, accepting the input from the Planner subsystem and coordinating the telescope, camera, and...
Published: 12/9/2024
|
Inventor(s):
A Departmental Work
Keywords(s):
Category(s):
Technology Classifications > Software & Information Technology > Open Source
,
Technology Classifications > Software & Information Technology
Planner – Planning Software for Near-Earth Object Survey Operations
The Planner subsystem in the Catalina Sky Survey (CSS) software suite is designed to help observers efficiently plan nightly asteroid and Near-Earth Object (NEO) observations. By displaying a virtual map of the sky, it helps ensure that areas previously searched, or areas unlikely to be productive, are avoided. The map shows the telescope’s current...
Published: 12/9/2024
|
Inventor(s):
A Departmental Work
Keywords(s):
Category(s):
Technology Classifications > Software & Information Technology > Open Source
,
Technology Classifications > Software & Information Technology
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