Search Results - therapeutics+%3e+inflammation+and+inflammatory+diseases

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Compositions and Methods to Modulate MAVS-Mediated Immunity (UCLA Case No. 2026-096)
UCLA researchers in the Department of Microbiology, Immunology, and Molecular Genetics have developed methods to target TOM70, a mitochondrial outer membrane protein, to selectively modulate innate immune signaling and control pathological or protective immune responses across a range of clinical conditions. BACKGROUND: Innate immune detection of viral...
Published: 2/18/2026   |   Inventor(s): Lena Pernas
Keywords(s):  
Category(s): Diagnostic Markers > Targets And Assays, Diagnostic Markers > Immunology, Diagnostic Markers > Cancer, Platforms > Diagnostic Platform Technologies, Therapeutics > Oncology, Therapeutics > Infectious Diseases, Therapeutics > Immunology And Immunotherapy, Therapeutics > Inflammation And Inflammatory Diseases, Therapeutics > Autoimmune, Therapeutics > Vaccines
Indole-3-Propionic Acid (IPA) Protects Against Heart Failure with Preserved Ejection Fraction (HFpEF) (UCLA Case No. 2022-142)
UCLA researchers in the Department of Medicine, Division of Cardiology have identified the protective effects of gut-heart crosstalk mediated by 3-propionic acid (IPA) in the progression of heart failure with preserved ejection fraction (HFpEF). IPA supplementation could rescue the IPA deficiency associated heart defects, protect against heart malfunction,...
Published: 2/26/2026   |   Inventor(s): Aldons Lusis, Yang Cao
Keywords(s):  
Category(s): Therapeutics > Cardiovascular, Therapeutics > Inflammation And Inflammatory Diseases, Therapeutics > Metabolism And Endocrinology
Regulated Gene Expression During Differentiation of Mature T Cells (UCLA Case No. 2022-147)
UCLA researchers from the Department of Pathology & Laboratory Medicine have developed a process to genetically modify stem cells to express transgenes in a regulated, stage-specific manner, avoiding the negative consequences of transgene expression during T cell development. Contact UCLA Technology Development Group for more information.
Published: 1/27/2026   |   Inventor(s): Gay Crooks, Donald Kohn
Keywords(s):  
Category(s): Therapeutics > Gene Therapy And Editing, Therapeutics > Stem Cells And Regenerative Medicine, Therapeutics > Oncology, Therapeutics > Immunology And Immunotherapy, Therapeutics > Inflammation And Inflammatory Diseases
Highly Selective Targeting of Interleukin 12 P40 Gene Expression for the Treatment of Autoimmune Diseases (UCLA Case No. 2020-864)
UCLA researchers from the Department of Microbiology, Immunology and Molecular Genetics have identified key inhibitors and inhibitory pathways targeting a pro- inflammatory molecule implicated in a vast array of autoinflammatory diseases. BACKGROUND: Inflammatory autoimmune diseases are a broad group of disorders of the immune system where the body...
Published: 10/22/2025   |   Inventor(s): Stephen Smale
Keywords(s):  
Category(s): Therapeutics > Autoimmune, Therapeutics > Dermatology, Therapeutics > Inflammation And Inflammatory Diseases
Covalent Inhibitors and High Throughput Screening Platform for Inhibitor Discovery for Caspase-10 and Related Caspases (UCLA Case No. 2025-130)
UCLA researchers in the Department of Biological Chemistry have developed a high throughput screening platform to identify state-specific protease inhibitors, enabling identification of two inhibitor classes that preferentially show zymogen-directed caspase-10 inhibition. BACKGROUND: Caspases are a conserved family of cysteine proteases that play important...
Published: 2/2/2026   |   Inventor(s): Keriann Backus
Keywords(s):  
Category(s): Therapeutics > Inflammation And Inflammatory Diseases, Diagnostic Markers > Targets And Assays, Life Science Research Tools > Other Reagents, Life Science Research Tools > Research Methods
Targeting the SV2 Family of Proteins for Immune Regulation (UCLA Case No. 2021-122)
UCLA researchers in the Department of Medicine have identified the SV2 family of proteins as novel druggable targets for suppressing severe inflammation, including COVID-19 pneumonia. Background: In critical COVID-19, the infection causes severe inflammation and excess fluid in the lungs, leading to breathing difficulties (COVID-19 pneumonia). Recent...
Published: 8/13/2025   |   Inventor(s): Ke Shuai
Keywords(s):  
Category(s): Therapeutics > Inflammation And Inflammatory Diseases, Therapeutics > Respiratory And Pulmonary
Targeting Plasma Extracellular Vesicles as Therapy for Severe Bacterial Pneumonia (UCLA Case No. 2025-274)
UCLA researchers in the Department of Anesthesiology & Perioperative Medicine have identified a novel method of targeting plasma extracellular vesicles to help suppress inflammation and infection during severe bacterial pneumonia. BACKGROUND: Direct and indirect lung injury such as through pneumonia or following abdominal infections can lead to...
Published: 7/17/2025   |   Inventor(s): Jae Woo Lee
Keywords(s):  
Category(s): Therapeutics > Infectious Diseases, Therapeutics > Inflammation And Inflammatory Diseases, Therapeutics > Respiratory And Pulmonary
Ingestible Device for Medical Interaction With the Gastrointestinal Tract and Surrounding Tissues (Case No. 2024-226)
Summary: UCLA researchers have conceptualized an ingestible, self-powered, and wireless capsule that can be used to effectively diagnose and treat gastrointestinal disorders. Background: Gastrointestinal (GI) disorders, including conditions like irritable bowel syndrome, Crohn’s disease, and gastroparesis, impact millions of people worldwide...
Published: 8/12/2025   |   Inventor(s): Wentai Liu, Ryan Kochis, Brian Arianpour, Alejandro Miron Jabalera
Keywords(s): Biosensor, brain-gut microbiome, Gastroenterology, Gastroenterology & Digestive Disease, gastrointestinal (GI) tract diseases, gut inflammation, Human Gastrointestinal Tract, minimally invasive device, Neuromodulation, wireless capsule endoscopy
Category(s): Therapeutics > Inflammation And Inflammatory Diseases, Therapeutics > Gastroenterology, Software & Algorithms > Digital Health, Medical Devices > Monitoring And Recording Systems, Mechanical > Sensors, Chemical > Chemical Sensors, Life Science Research Tools > Screening Libraries
A Diagnostic Epigenetic Score for Determining the Effect of Biomarkers for Asthma Drug Response (UCLA Case No. 2024-106)
UCLA researchers in the Department of Computational Medicine have developed a novel machine learning algorithm to generate an accurate molecular score for determining asthma drug response. BACKGROUND: Asthma is a globally prevalent, high-burden disease marked by substantial clinical heterogeneity and variable treatment response. This heterogeneity...
Published: 7/17/2025   |   Inventor(s): Elior Rahmani
Keywords(s):  
Category(s): Platforms > Diagnostic Platform Technologies, Diagnostic Markers > Targets And Assays, Software & Algorithms > AI Algorithms, Software & Algorithms > Digital Health, Therapeutics > Inflammation And Inflammatory Diseases
Method for Non-invasive Assessment of Pressure and Cardiac Efficiency (Case No. 2024-258)
Summary: Researchers in the Department of Medicine and Radiological Sciences at UCLA have developed a novel computational model for estimating ventricular mechanical efficiency using routine clinical exam practices. Background: Congenital heart disease (CHD) involves complex heart defects that make it harder for the heart to pump blood effectively....
Published: 10/24/2025   |   Inventor(s): Kim-Lien Nguyen, Sanjib Gurung, John Finn
Keywords(s): acute myocardial infarction, Blood Pressure, Catheterization, heart disease mitigation, heart failure, heart support, hemodynamic monitoring, ventricular system
Category(s): Therapeutics > Cardiovascular, Therapeutics > Radiology, Medical Devices > Cardiac, Medical Devices > Monitoring And Recording Systems, Therapeutics > Inflammation And Inflammatory Diseases, Medical Devices > Medical Imaging, Software & Algorithms > Bioinformatics
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