Search Results - therapeutics+%3e+inflammation+and+inflammatory+diseases

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Regulated Gene Expression During Differentiation of Mature T Cells (UCLA Case No. 2022-147)
UCLA researchers from the Department of Pathology & Laboratory Medicine have developed a process to genetically modify stem cells to express transgenes in a regulated, stage-specific manner, avoiding the negative consequences of transgene expression during T cell development. Contact UCLA Technology Development Group for more information.
Published: 1/27/2026   |   Inventor(s): Gay Crooks, Donald Kohn
Keywords(s):  
Category(s): Therapeutics > Gene Therapy And Editing, Therapeutics > Stem Cells And Regenerative Medicine, Therapeutics > Oncology, Therapeutics > Immunology And Immunotherapy, Therapeutics > Inflammation And Inflammatory Diseases
Highly Selective Targeting of Interleukin 12 P40 Gene Expression for the Treatment of Autoimmune Diseases (UCLA Case No. 2020-864)
UCLA researchers from the Department of Microbiology, Immunology and Molecular Genetics have identified key inhibitors and inhibitory pathways targeting a pro- inflammatory molecule implicated in a vast array of autoinflammatory diseases. BACKGROUND: Inflammatory autoimmune diseases are a broad group of disorders of the immune system where the body...
Published: 10/22/2025   |   Inventor(s): Stephen Smale
Keywords(s):  
Category(s): Therapeutics > Autoimmune, Therapeutics > Dermatology, Therapeutics > Inflammation And Inflammatory Diseases
Targeting the SV2 Family of Proteins for Immune Regulation (UCLA Case No. 2021-122)
UCLA researchers in the Department of Medicine have identified the SV2 family of proteins as novel druggable targets for suppressing severe inflammation, including COVID-19 pneumonia. Background: In critical COVID-19, the infection causes severe inflammation and excess fluid in the lungs, leading to breathing difficulties (COVID-19 pneumonia). Recent...
Published: 8/13/2025   |   Inventor(s): Ke Shuai
Keywords(s):  
Category(s): Therapeutics > Inflammation And Inflammatory Diseases, Therapeutics > Respiratory And Pulmonary
Targeting Plasma Extracellular Vesicles as Therapy for Severe Bacterial Pneumonia (UCLA Case No. 2025-274)
UCLA researchers in the Department of Anesthesiology & Perioperative Medicine have identified a novel method of targeting plasma extracellular vesicles to help suppress inflammation and infection during severe bacterial pneumonia. BACKGROUND: Direct and indirect lung injury such as through pneumonia or following abdominal infections can lead to...
Published: 7/17/2025   |   Inventor(s): Jae Woo Lee
Keywords(s):  
Category(s): Therapeutics > Infectious Diseases, Therapeutics > Inflammation And Inflammatory Diseases, Therapeutics > Respiratory And Pulmonary
Ingestible Device for Medical Interaction With the Gastrointestinal Tract and Surrounding Tissues (Case No. 2024-226)
Summary: UCLA researchers have conceptualized an ingestible, self-powered, and wireless capsule that can be used to effectively diagnose and treat gastrointestinal disorders. Background: Gastrointestinal (GI) disorders, including conditions like irritable bowel syndrome, Crohn’s disease, and gastroparesis, impact millions of people worldwide...
Published: 8/12/2025   |   Inventor(s): Wentai Liu, Ryan Kochis, Brian Arianpour, Alejandro Miron Jabalera
Keywords(s): Biosensor, brain-gut microbiome, Gastroenterology, Gastroenterology & Digestive Disease, gastrointestinal (GI) tract diseases, gut inflammation, Human Gastrointestinal Tract, minimally invasive device, Neuromodulation, wireless capsule endoscopy
Category(s): Therapeutics > Inflammation And Inflammatory Diseases, Therapeutics > Gastroenterology, Software & Algorithms > Digital Health, Medical Devices > Monitoring And Recording Systems, Mechanical > Sensors, Chemical > Chemical Sensors, Life Science Research Tools > Screening Libraries
A Diagnostic Epigenetic Score for Determining the Effect of Biomarkers for Asthma Drug Response (UCLA Case No. 2024-106)
UCLA researchers in the Department of Computational Medicine have developed a novel machine learning algorithm to generate an accurate molecular score for determining asthma drug response. BACKGROUND: Asthma is a globally prevalent, high-burden disease marked by substantial clinical heterogeneity and variable treatment response. This heterogeneity...
Published: 7/17/2025   |   Inventor(s): Elior Rahmani
Keywords(s):  
Category(s): Platforms > Diagnostic Platform Technologies, Diagnostic Markers > Targets And Assays, Software & Algorithms > AI Algorithms, Software & Algorithms > Digital Health, Therapeutics > Inflammation And Inflammatory Diseases
Method for Non-invasive Assessment of Pressure and Cardiac Efficiency (Case No. 2024-258)
Summary: Researchers in the Department of Medicine and Radiological Sciences at UCLA have developed a novel computational model for estimating ventricular mechanical efficiency using routine clinical exam practices. Background: Congenital heart disease (CHD) involves complex heart defects that make it harder for the heart to pump blood effectively....
Published: 10/24/2025   |   Inventor(s): Kim-Lien Nguyen, Sanjib Gurung, John Finn
Keywords(s): acute myocardial infarction, Blood Pressure, Catheterization, heart disease mitigation, heart failure, heart support, hemodynamic monitoring, ventricular system
Category(s): Therapeutics > Cardiovascular, Therapeutics > Radiology, Medical Devices > Cardiac, Medical Devices > Monitoring And Recording Systems, Therapeutics > Inflammation And Inflammatory Diseases, Medical Devices > Medical Imaging, Software & Algorithms > Bioinformatics
Bone Depth Gauge Design and Deployable Mechanism (Case No. 2024-185)
Summary: Researchers in the Department of Head and Neck Surgery at UCLA have developed a novel bone depth gauge and deployable mechanism for orthopaedic screw insertion. Background: Orthopaedic screws are typically used in surgeries to treat fractures that may have been caused intentionally, such as for tumor resection or joint replacement, or...
Published: 8/21/2025   |   Inventor(s): Ashley Kita, Eric Smith, Rhorie Kerr
Keywords(s): bone health, Invasiveness Of Surgical Procedures, Orthopaedics, Orthopedics and Prosthetics (O & P), Surgical Instrument, surgical tool
Category(s): Diagnostic Markers > Aging, Mechanical > Sensors, Medical Devices, Medical Devices > Surgical Tools, Therapeutics > Orthopaedics, Therapeutics > Musculoskeletal Disease, Therapeutics > Inflammation And Inflammatory Diseases
Interferon Activation Score Is a Biomarker for Immunotherapy in Malignant Glioma Patients (UCLA Case No. 2024-043)
UCLA researchers from the Department of Neurosurgery have characterized immune responses in malignant glioma patients receiving immunotherapy to develop a robust biomarker that will allow prediction of clinical outcomes following treatment. BACKGROUND: Malignant gliomas are the most common primary brain tumors in adults. No cures exist and most gliomas...
Published: 7/31/2025   |   Inventor(s): Robert Prins
Keywords(s): adjuvant therapy, Biomarker, Chemotherapy, Clinical Trial, dendritic cell vaccination, Glioblastoma, Glioma, immune response, Immunotherapy, interferon, malignant glioma
Category(s): Diagnostic Markers > Immunology, Diagnostic Markers > Cancer, Therapeutics > Inflammation And Inflammatory Diseases, Therapeutics > Oncology, Therapeutics > CNS and Neurology
Quercetin as substrate for antiviral treatment against Hepatitis C virus infection (UCLA Case No. 2023-003)
UCLA researchers in the Department of Pathology and Hematology have developed a novel antiviral treatment for Hepatitis C virus based on the metabolic modulating properties of dietary compound Quercetin. BACKGROUND: Hepatitis C virus (HCV) is responsible for 180 million infections worldwide and over 12,000 deaths in the U.S. each year. Despite most...
Published: 2/14/2025   |   Inventor(s): Nu Lu
Keywords(s): antivirals, hepatitis, immune metabolism, Inflammation, liver disease
Category(s): Therapeutics > Infectious Diseases, Therapeutics > Inflammation And Inflammatory Diseases
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