Search Results - therapeutics+%3e+inflammation+and+inflammatory+diseases

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Active Electromagnetic Interference Suppression for Magnetic Resonance Imaging-Guided Interventions (Case No. 2026-217)

Summary: UCLA researchers in the Department of Radiological Sciences have developed a software-based active electromagnetic interference suppression solution for real-time MRI-guided interventions. Background: Microwave ablation (MWA) has emerged as the preferred thermal ablation modality for treating non-surgical patients with primary and metastatic...

Published: 4/16/2026 | Updated: 4/14/2026 | Inventor(s): Holden Wu, Qing Dai

Keywords(s):

Category(s): Software & Algorithms, Software & Algorithms > AI Algorithms, Software & Algorithms > Artificial Intelligence & Machine Learning, Software & Algorithms > Image Processing, Medical Devices, Medical Devices > Medical Imaging, Medical Devices > Medical Imaging > MRI, Life Science Research Tools, Life Science Research Tools > Microscopy And Imaging, Life Science Research Tools > Lab Equipment, Medical Devices > Monitoring And Recording Systems, Therapeutics, Therapeutics > CNS and Neurology, Therapeutics > Immunology And Immunotherapy, Therapeutics > Inflammation And Inflammatory Diseases, Mechanical, Mechanical > Instrumentation, Mechanical > Sensors, Electrical, Electrical > Electronics & Semiconductors, Electrical > Signal Processing, Electrical > Instrumentation, Electrical > Imaging

Compositions and Methods to Modulate MAVS-Mediated Immunity (UCLA Case No. 2026-096)

UCLA researchers in the Department of Microbiology, Immunology, and Molecular Genetics have developed methods to target TOM70, a mitochondrial outer membrane protein, to selectively modulate innate immune signaling and control pathological or protective immune responses across a range of clinical conditions. BACKGROUND: Innate immune detection of viral...

Published: 2/18/2026 | Updated: 2/18/2026 | Inventor(s): Lena Pernas

Keywords(s):

Category(s): Diagnostic Markers > Targets And Assays, Diagnostic Markers > Immunology, Diagnostic Markers > Cancer, Platforms > Diagnostic Platform Technologies, Therapeutics > Oncology, Therapeutics > Infectious Diseases, Therapeutics > Immunology And Immunotherapy, Therapeutics > Inflammation And Inflammatory Diseases, Therapeutics > Autoimmune, Therapeutics > Vaccines

Indole-3-Propionic Acid (IPA) Protects Against Heart Failure with Preserved Ejection Fraction (HFpEF) (UCLA Case No. 2022-142)

UCLA researchers in the Department of Medicine, Division of Cardiology have identified the protective effects of gut-heart crosstalk mediated by 3-propionic acid (IPA) in the progression of heart failure with preserved ejection fraction (HFpEF). IPA supplementation could rescue the IPA deficiency associated heart defects, protect against heart malfunction,...

Published: 2/26/2026 | Updated: 2/5/2026 | Inventor(s): Aldons Lusis, Yang Cao

Keywords(s):

Category(s): Therapeutics > Cardiovascular, Therapeutics > Inflammation And Inflammatory Diseases, Therapeutics > Metabolism And Endocrinology

Regulated Gene Expression During Differentiation of Mature T Cells (UCLA Case No. 2022-147)

UCLA researchers from the Department of Pathology & Laboratory Medicine have developed a process to genetically modify stem cells to express transgenes in a regulated, stage-specific manner, avoiding the negative consequences of transgene expression during T cell development. Contact UCLA Technology Development Group for more information.

Published: 1/27/2026 | Updated: 1/27/2026 | Inventor(s): Gay Crooks, Donald Kohn

Keywords(s):

Category(s): Therapeutics > Gene Therapy And Editing, Therapeutics > Stem Cells And Regenerative Medicine, Therapeutics > Oncology, Therapeutics > Immunology And Immunotherapy, Therapeutics > Inflammation And Inflammatory Diseases

Highly Selective Targeting of Interleukin 12 P40 Gene Expression for the Treatment of Autoimmune Diseases (UCLA Case No. 2020-864)

UCLA researchers from the Department of Microbiology, Immunology and Molecular Genetics have identified key inhibitors and inhibitory pathways targeting a pro- inflammatory molecule implicated in a vast array of autoinflammatory diseases. BACKGROUND: Inflammatory autoimmune diseases are a broad group of disorders of the immune system where the body...

Published: 10/22/2025 | Updated: 10/3/2025 | Inventor(s): Stephen Smale

Keywords(s):

Category(s): Therapeutics > Autoimmune, Therapeutics > Dermatology, Therapeutics > Inflammation And Inflammatory Diseases

A Microbial Metabolite That Promotes Stress/Anxiety (UCLA Case No. 2026-007)

UCLA researchers in the Department of Integrative Biology and Physiology have identified microbiota-derived imidazole propionate (ImP) as a key neuromodulatory signal that can be targeted to treat stress-related behaviors and metabolic dysfunction. BACKGROUND: The microbiota-gut-brain axis is a complex network that coordinates metabolic homeostasis....

Published: 5/22/2026 | Updated: 9/19/2025 | Inventor(s): Elaine Hsiao, Gulistan Agirman

Keywords(s):

Category(s): Therapeutics > Metabolism And Endocrinology, Diagnostic Markers > Targets And Assays, Therapeutics > Inflammation And Inflammatory Diseases, Therapeutics > CNS and Neurology

Targeting Metabolic and Molecular Drivers to Stop Treatment- and Immune-Resistant Pancreatic Ductal Adenocarcinoma (UCLA Case No. 2025-9AD)

UCLA researchers in the Department of Medicine–Hematology/Oncology have developed next-generation metformin analogs that show improved antitumor efficacy and tumor microenvironment remodeling in pancreatic cancer. BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is the 3rd leading cause of cancer-related death in the U.S. with a 5-year survival...

Published: 5/28/2026 | Updated: 9/19/2025 | Inventor(s): Richard Pietras, Michael Jung, Timothy Donahue, Diana Marquez-Garban

Keywords(s):

Category(s): Therapeutics > Oncology, Therapeutics > Metabolism And Endocrinology, Therapeutics > Inflammation And Inflammatory Diseases

Covalent Inhibitors and High Throughput Screening Platform for Inhibitor Discovery for Caspase-10 and Related Caspases (UCLA Case No. 2025-130)

UCLA researchers in the Department of Biological Chemistry have developed a high throughput screening platform to identify state-specific protease inhibitors, enabling identification of two inhibitor classes that preferentially show zymogen-directed caspase-10 inhibition. BACKGROUND: Caspases are a conserved family of cysteine proteases that play important...

Published: 2/2/2026 | Updated: 9/18/2025 | Inventor(s): Keriann Backus

Keywords(s):

Category(s): Therapeutics > Inflammation And Inflammatory Diseases, Diagnostic Markers > Targets And Assays, Life Science Research Tools > Other Reagents, Life Science Research Tools > Research Methods

Targeting the SV2 Family of Proteins for Immune Regulation (UCLA Case No. 2021-122)

UCLA researchers in the Department of Medicine have identified the SV2 family of proteins as novel druggable targets for suppressing severe inflammation, including COVID-19 pneumonia. Background: In critical COVID-19, the infection causes severe inflammation and excess fluid in the lungs, leading to breathing difficulties (COVID-19 pneumonia). Recent...

Published: 8/13/2025 | Updated: 8/13/2025 | Inventor(s): Ke Shuai

Keywords(s):

Category(s): Therapeutics > Inflammation And Inflammatory Diseases, Therapeutics > Respiratory And Pulmonary

Targeting Plasma Extracellular Vesicles as Therapy for Severe Bacterial Pneumonia (UCLA Case No. 2025-274)

UCLA researchers in the Department of Anesthesiology & Perioperative Medicine have identified a novel method of targeting plasma extracellular vesicles to help suppress inflammation and infection during severe bacterial pneumonia. BACKGROUND: Direct and indirect lung injury such as through pneumonia or following abdominal infections can lead to...

Published: 7/17/2025 | Updated: 6/27/2025 | Inventor(s): Jae Woo Lee

Keywords(s):

Category(s): Therapeutics > Infectious Diseases, Therapeutics > Inflammation And Inflammatory Diseases, Therapeutics > Respiratory And Pulmonary

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