Search Results - therapeutics+%3e+immunology+and+immunotherapy

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B Cell-Based Assay to Expand Antigen-Specific T Cells (UCLA Case No. 2025-288)
UCLA researchers from the Department of Medicine have developed a novel B cell-based assay to expand antigen-specific T cells, allowing for an efficient, patient-specific platform to generate tumor antigen-specific T cells. BACKGROUND: Adoptive T cell therapies have emerged as a promising strategy for cancer immunotherapy, enabling the expansion of...
Published: 11/6/2025   |   Inventor(s): Yuanyuan Tong, Willy Hugo, Maureen Su, Melissa Lechner, Robert Prins
Keywords(s):  
Category(s): Therapeutics > Oncology, Therapeutics > Immunology And Immunotherapy
Pancreas Cancer Immunotherapy using Cationic Lipid and Polymer Nanocarriers for co-delivery of KRAS Neoantigens and STING or other immunomodulators to boost the Cancer Immunity Cycle and Treat Liver Metastasis (UCLA Case No. 2024-076)
UCLA researchers have developed a translational immunotherapy platform that leverages nanoparticle-based delivery of tumor-associated signals and immune-stimulatory molecules to drive localized immune activation in metastatic pancreatic cancer. This approach is designed to initiate de novo immune priming and recondition the tumor microenvironment in...
Published: 10/29/2025   |   Inventor(s): Andre Nel
Keywords(s):  
Category(s): Therapeutics > Oncology, Therapeutics > Immunology And Immunotherapy, Therapeutics > Vaccines, Platforms > Drug Delivery
Unique Tests to Assess the Expansion and Function of Natural Killer Cells in Health and Disease (UCLA Case No. 2019-635)
UCLA researchers in the School of Dentistry have developed a unique set of tests to determine the expansion and function of natural killer cells in healthy subjects and cancer patients. BACKGROUND: Natural killer (NK) cells have the remarkable ability to target cancer stem cells (CSCs) and undifferentiated tumors. However, downregulation of NK receptors...
Published: 10/23/2025   |   Inventor(s): Anahid Jewett
Keywords(s):  
Category(s): Diagnostic Markers > Immunology, Therapeutics > Immunology And Immunotherapy, Life Science Research Tools > Cell Lines
Sonicated Osteoclasts as Drugs to Increase NK Expansion and Function in Patients and in Manufacturing of NK Cells (Case No. 2024-272)
UCLA researchers from the Department of Dentistry have developed an innovative method to manufacture, expand and improve the function of natural killer cells by using sonicated osteoclasts for cancer immunotherapy. BACKGROUND: Natural killer cells (NK cells) are immune cells that recognize and combat pathogens and cancer cells. NK cell immunotherapy...
Published: 10/23/2025   |   Inventor(s): Anahid Jewett
Keywords(s):  
Category(s): Therapeutics > Oncology, Therapeutics > Immunology And Immunotherapy, Therapeutics > Oncology > Oncology Immunotherapy
Curative Locoregional Therapy Using Ablation or Catheter-Based Embolization of Targeted Hepatocellular Carcinoma by Delivering Supercharged NK Cells and CAR-NK or CAR-T Cells (UCLA Case No. 2023-115)
UCLA researchers in the School of Dentistry and Interventional Radiology have developed a groundbreaking curative treatment for hepatocellular carcinoma that combines locoregional therapy, such as ablation or catheter-based embolization, with targeted delivery of supercharged NK cells and CAR-NK or CAR-T cells, offering a highly effective approach that...
Published: 10/31/2025   |   Inventor(s): Anahid Jewett, Steven Raman, Jason Chiang
Keywords(s):  
Category(s): Therapeutics > Oncology, Therapeutics > Immunology And Immunotherapy, Therapeutics > Oncology > Oncology Immunotherapy
Antiviral Compounds Inhibiting Zika Virus (ZIKV), and Methods and Zika Treatment Thereof (UCLA Case No. 2025-241)
UCLA researchers from the Molecular and Medical Pharmacology Department and CNSI have identified antiviral compounds that effectively inhibit Zika virus infection and cytopathic effects, potentially leading to improved therapeutics and treatment outcomes. BACKGROUND: Zika virus (ZIKV), a flavivirus now endemic to several regions globally, can cause...
Published: 10/3/2025   |   Inventor(s): Vaithilingaraja Arumugaswami, Robert Damoiseaux
Keywords(s):  
Category(s): Life Science Research Tools > Screening Libraries, Diagnostic Markers > Immunology, Diagnostic Markers > Targets And Assays, Therapeutics > Infectious Diseases, Therapeutics > CNS and Neurology, Therapeutics > Immunology And Immunotherapy, Platforms > Diagnostic Platform Technologies
IL-2 Independent Ultrahigh Human T Cell Activations Through Biomimetics of Immune Synapses by Graphene Oxides (UCLA Case No. 2021-068)
UCLA researchers in the Department of Materials Science and Engineering have constructed a novel graphene oxide-based platform for robust T cell activation through artificial immune synapse formation. BACKGROUND: T cells are a critical arm of the immune system with tremendous therapeutic value for immune disorders and cancer. However, modulation of...
Published: 10/2/2025   |   Inventor(s): Yu Huang, Lili Yang
Keywords(s):  
Category(s): Therapeutics > Oncology, Therapeutics > Immunology And Immunotherapy
Methods and Compositions for Promoting Anti-Tumor Immunity of T Cells (UCLA Case No. 2026-037)
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Published: 9/19/2025   |   Inventor(s): Alexandra Nicoleta Boix De Jesus, Joseph Crompton, Hy Dao
Keywords(s):  
Category(s): Therapeutics > Immunology And Immunotherapy, Therapeutics > Oncology
Catch Bond-Enhanced Human T Cell Receptors Targeting Prostatic Acid Phosphatase on HLA-A*02:01 (UCLA Case No. 2025-138)
UCLA researchers from the Department of Microbiology, Immunology, and Molecular Genetics and Stanford researchers from the Department of Molecular and Cellular Physiology have developed novel enhanced T cell receptors engineered to specifically recognize prostatic acid phosphatase, offering a powerful and precise immunotherapeutic strategy for prostate...
Published: 9/19/2025   |   Inventor(s): Owen Witte, Zhiyuan Mao, John Lee, Kenan Christoph Garcia
Keywords(s):  
Category(s): Therapeutics > Oncology, Therapeutics > Immunology And Immunotherapy
Self-Amplifying RNA Form of a Constitutively-Active Sting Protein for Enhancing T-Cell Response to Antigen-Presenting Cells (UCLA Case No. 2020-771)
UCLA researchers in the Department of Chemistry and Biochemistry have developed a novel method for delivering RNA to induce an immune response to cancer cells. BACKGROUND: Cancer therapy continues to remain a challenge despite improvements in detection and clinically available therapies. Recently, improvements to this field have been mainly in the...
Published: 10/22/2025   |   Inventor(s): William Gelbart
Keywords(s): Adenoviridae
Category(s): Therapeutics, Therapeutics > Immunology And Immunotherapy, Therapeutics > Oncology > Oncology Immunotherapy, Diagnostic Markers > Targets And Assays
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