Search Results - therapeutics+%3e+immunology+and+immunotherapy

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Methods To Predict the Efficacy of Neoadjuvant Anti-PD-1 Therapy in Resectable Oral-Cavity Squamous Cell Carcinoma and Target Post-Surgical Relapses (UCLA Case No. 2022-039)
UCLA researchers in the School of Medicine have developed a novel therapeutic strategy to improve prognosis of resectable head and neck cancer patients based on clinical studies. BACKGROUND: Head and neck squamous cell carcinoma (HNSCC) is an aggressive and recurrent cancer, ranked sixth among common epithelial malignancies worldwide. Over a third...
Published: 11/4/2024   |   Inventor(s): Roger Lo
Keywords(s): anti-PD-1, head and neck cancer, head and neck squamous cell carcinoma (HNSCC), Immunotherapy, oral cavity squamous cell carcinoma (OCSCC), resectable tumors
Category(s): Therapeutics > Oncology, Therapeutics > Immunology And Immunotherapy
Combination Cancer Therapy Methods and Agents (UCLA Case No. 2024-084)
UCLA researchers from the Department of Medicine, Pathology, & Laboratory Medicine and Molecular & Medical Pharmacology have identified a novel cell-based therapy that leads to enhanced immunotherapy efficacy and overcomes treatment resistance to immune checkpoint blockade in non-small cell lung cancer. BACKGROUND: Non-small cell lung cancer...
Published: 11/4/2024   |   Inventor(s): Bin Liu, Steven Dubinett
Keywords(s): anti-tumor immunity, cell-based therapy, Immune checkpoint blockade, Immunotherapy, non-small cell lung cancer, treatment resistance, Tumor microenvironment, Vaccines
Category(s): Therapeutics > Oncology, Therapeutics > Immunology And Immunotherapy, Therapeutics > Respiratory And Pulmonary
Oleate-Mediated Enhancement of Human Natural Killer Cell Function (UCLA Case No. 2024-180)
UCLA researchers in the Department of Microbiology, Immunology and Molecular Genetics have discovered a novel approach to boost natural killer cell function through fatty acid supplementation. BACKGROUND: Natural killer (NK) cells are part of the body’s defense system that hunts down and kills cells that are infected by viruses or have become...
Published: 10/7/2024   |   Inventor(s): Timothy O'Sullivan
Keywords(s): fatty acids, immune defense, immune disorders, Immunology, natural killer cells, nk cells
Category(s): Therapeutics > Immunology And Immunotherapy
Functional Enrichment and Purification of a Therapeutically Superior Population of Cells (Case No. 2024-024)
Summary: UCLA researchers in the Departments of Bioengineering and Biological Chemistry have developed a method for identifying and enriching therapeutically useful cell sub-populations based on their secretions (SEC-seq). Background: Cell function is defined by a myriad of biomolecules that they secrete; over 3 thousand proteins are estimated to...
Published: 9/11/2024   |   Inventor(s): Dino Di Carlo, Kathrin Plath, Shreya Udani, Justin Langerman
Keywords(s): Cell Surface Receptor, Cytometry, Flow Cytometry, Functional Genomics, High-Throughput Screening, hydrogel, Microfluidics, single cell analysis, Therapeutics
Category(s): Therapeutics > Immunology And Immunotherapy, Therapeutics, Therapeutics > Oncology > Oncology Immunotherapy, Life Science Research Tools, Life Science Research Tools > Research Methods, Diagnostic Markers > Targets And Assays, Therapeutics > Cell Therapy
Affinity and Functional Based Screening of T Cell Receptor Repertoire Using Nanovials (Case No. 2024-042)
Summary: Researchers in the Department of Bioengineering at UCLA have developed a hydrogel platform that measures single T cell secretions, aiding in the definition of T cell receptor repertoires for functional immunotherapy applications. Background: T cell immunotherapies, namely T cell receptor (TCR) therapies, have emerged as promising candidates...
Published: 10/8/2024   |   Inventor(s): Dino Di Carlo, Owen Witte, Doyeon Koo, Zhiyuan Mao
Keywords(s): Cancer Immunotherapy, CAR-T cell therapy, Flow Cytometry, hydrogel, Immunooncology, Immunotherapy, Peptide, single cell analysis, T Cell, T cell based therapy
Category(s): Diagnostic Markers > Immunology, Life Science Research Tools > Screening Libraries, Therapeutics > Immunology And Immunotherapy
Identifying Desirable T Lymphocytes by Change in Mass Responses (Case No. 2013-183)
Summary: UCLA researchers from the Department of Pathology and Lab Medicine have developed a novel method for the identification of T lymphocytes using live cell interferometry Background: The identification of T cell receptors (TCRs) that are specific to antigens is crucial for advancing various immunotherapies. Existing methods of characterizing...
Published: 8/15/2024   |   Inventor(s): Michael Teitell, Owen Witte, Thomas Zangle, Daina Burnes Linton
Keywords(s):  
Category(s): Therapeutics, Therapeutics > Immunology And Immunotherapy, Therapeutics > Autoimmune, Life Science Research Tools, Life Science Research Tools > Research Methods, Life Science Research Tools > Lab Equipment
Methods and Compositions for Treating Melanoma (UCLA Case No. 2021-324)
The Graeber Laboratory at UCLA discovered a novel mechanism for treating melanoma using ferroptosis, a type of programmed cell death, that shows promise against therapy resistance. BACKGROUND: Melanoma is a highly aggressive skin cancer that spreads throughout the body and can be fatal if left untreated. Therapies for melanoma range from immunotherapy...
Published: 7/10/2024   |   Inventor(s): Thomas Graeber
Keywords(s): Cancer, ferroptosis, Immunotherapy, MAPK signaling, Melanoma, Oncology, Skin, tumor resistance
Category(s): Therapeutics > Oncology, Therapeutics > Immunology And Immunotherapy
Targeting Serotonin Transporter (SERT) for Cancer Immunotherapy (UCLA Case No. 2024-204)
UCLA researchers in the Department of Microbiology Immunology and Molecular Genetics have unveiled a novel therapeutic strategy utilizing SSRIs for solid cancer immunotherapy. BACKGROUND: Immunotherapy has become a highly effective method to combat cancer that enhances a patient’s immune system to attack tumors with high specificity. For instance,...
Published: 6/18/2024   |   Inventor(s): Lili Yang
Keywords(s): Cancer, Immune checkpoint blockade, immune checkpoint inhibitors, Immunotherapy, selective serotonin reuptake inhibitors (SSRIs), serotonin, solid tumors, T Cell
Category(s): Therapeutics > Oncology, Therapeutics > Immunology And Immunotherapy
Inhibitory Chimeric Antigen Receptors That Reduce Car-T Cell “On-Target, Off-Tumor” Toxicity (UCLA Case No. 2022-186)
­SUMMARY: UCLA researchers in the Department of Microbiology, Immunology and Molecular Genetics, and the Department of Molecular and Medical Pharmacology have recently developed a novel approach which improves the kinetics and specificity of CAR T-cell therapy. BACKGROUND: Chimeric antigen receptor (CAR) T-cell therapy makes use of reengineered...
Published: 5/16/2024   |   Inventor(s): Owen Witte
Keywords(s): blood cancers, CAR-T cell therapy
Category(s): Therapeutics > Immunology And Immunotherapy, Therapeutics > Oncology, Therapeutics > Oncology > Oncology Immunotherapy, Therapeutics
Strategies to Detect, Prevent and Reverse Acquired Resistance to Immune Checkpoint Blockade Therapy (UCLA Case No. 2024-085)
UCLA researchers in the Department of Medicine have uncovered novel mechanism of acquired resistance against immune checkpoint blockade therapy in melanoma patients. BACKGROUND: Immune checkpoint blockade (ICB) therapy is a type of cancer immunotherapy that targets immune system components in order to reactivate immune cells to combat tumor cells....
Published: 5/8/2024   |   Inventor(s): Roger Lo
Keywords(s): acquired resistance, Apoptosis, Cancer, Cancer Immunotherapy, Immune checkpoint blockade, Immunotherapy, Melanoma, T Cell
Category(s): Therapeutics > Oncology, Therapeutics > Immunology And Immunotherapy
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