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Search Results - therapeutics+%3e+cns+and+neurology
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NPEPPS Enhancers for Treating Tau-Induced Neurodegeneration (UCLA Case No. 2018-161)
UCLA researchers from the Department of Neurology have developed first-in-class small-molecule activators of NPEPPS that effectively lower pathological tau, offering a novel disease-modifying strategy for Alzheimer’s and other neurodegenerative disorders. BACKGROUND: Neurodegenerative dementias such as Alzheimer’s Disease (AD) and progressive...
Published: 10/22/2025
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Inventor(s):
Daniel Geschwind
,
Robert Damoiseaux
,
Liting Deng
,
Michael Jung
,
Jennifer Murphy
,
Gaoyuan Ma
Keywords(s):
Category(s):
Therapeutics > CNS and Neurology
,
Diagnostic Markers > Targets And Assays
Brain Repair in Vascular Dementia and Stroke with A3AR (UCLA Case No. 2024-220)
UCLA researchers from the Department of Neurology have discovered and validated intercellular signaling pathways that can be therapeutically targeted to drive repair and functional recovery in vascular dementia. BACKGROUND: Vascular dementia (VaD) is the second leading cause of dementia and is driven by ischemic injury to cerebral white matter, producing...
Published: 10/14/2025
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Inventor(s):
Stanley Carmichael
Keywords(s):
Category(s):
Therapeutics > CNS and Neurology
,
Therapeutics > Cardiovascular
,
Life Science Research Tools > Animal Models
Directed Differentiation Protocols to Derive Bone Fide Spinal Sensory Interneurons (UCLA Case No. 2022-224)
UCLA researchers from the Department of Neurobiology have developed innovative protocols to differentiate and expand spinal sensory interneurons for drug discovery and to utilize in cell replacement therapies to restore injured spinal cords. BACKGROUND: Spinal cord injuries (SCIs) can result in the loss of controlled movement and somatosensation, the...
Published: 10/10/2025
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Inventor(s):
Samantha Butler
Keywords(s):
Category(s):
Life Science Research Tools > Research Methods
,
Therapeutics > Stem Cells And Regenerative Medicine
,
Therapeutics > CNS and Neurology
Broad-Band Frequency Repetitive Transcranial Magnetic Stimulation for the Treatment of Neuropsychiatric Disorders (Case No. 2025-99J)
Summary: Researchers in UCLA's Semel Institute and Department of Psychiatry have developed an innovative approach to treating depression by optimizing repetitive Transcranial Magnetic Stimulation (rTMS), improving its effectiveness for the treatment of Major Depressive Disorder (MDD) and possibly diseases of the mind and brain. Background: Depression...
Published: 10/16/2025
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Inventor(s):
Andrew Leuchter
,
Juliana Corlier
,
Thomas Valles
Keywords(s):
Bioelectromagnetics
,
Brain
,
Deep Brain Stimulation
,
Electrical Brain Stimulation
,
energy-efficient
,
frequency modulation
,
Magnetic Field
,
Medical Device
,
medication efficacy
,
neural information
,
neural network
,
neural networks
,
neural signals
,
neural stimulation
,
neurobehavioral impairment
,
Neurocognitive
,
neurological disorders
,
Neuromodulation
,
Neuron
,
neurons
,
neuroscience
,
Neurostimulation
,
pulsed load modulation
,
therapy
,
treatment efficacy
Category(s):
Medical Devices
,
Medical Devices > Neural Stimulation
,
Life Science Research Tools
,
Therapeutics > CNS and Neurology
,
Therapeutics
Antiviral Compounds Inhibiting Zika Virus (ZIKV), and Methods and Zika Treatment Thereof (UCLA Case No. 2025-241)
UCLA researchers from the Molecular and Medical Pharmacology Department and CNSI have identified antiviral compounds that effectively inhibit Zika virus infection and cytopathic effects, potentially leading to improved therapeutics and treatment outcomes. BACKGROUND: Zika virus (ZIKV), a flavivirus now endemic to several regions globally, can cause...
Published: 10/3/2025
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Inventor(s):
Vaithilingaraja Arumugaswami
,
Robert Damoiseaux
Keywords(s):
Category(s):
Life Science Research Tools > Screening Libraries
,
Diagnostic Markers > Immunology
,
Diagnostic Markers > Targets And Assays
,
Therapeutics > Infectious Diseases
,
Therapeutics > CNS and Neurology
,
Therapeutics > Immunology And Immunotherapy
,
Platforms > Diagnostic Platform Technologies
TRP: Human Schwannoma Cell Line (UCLA Case No. 2015-213)
UCLA researchers from the Department of Head & Neck Surgery have developed the only available human NF2 schwannoma cell line, offering an in vitro model for studying tumor cell biology and therapeutic development. BACKGROUND: Neurofibromatosis type 2 (NF2) is a rare autosomal dominant disorder caused by inactivating mutations in the NF2 tumor suppressor...
Published: 10/1/2025
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Inventor(s):
Marco Giovannini
Keywords(s):
Category(s):
Life Science Research Tools > Cell Lines
,
Therapeutics > Oncology
,
Therapeutics > CNS and Neurology
TRP: Cell Lines Expressing a DNA Construct Expressing Mutant TRPV4 (UCLA Case No. 2021-361)
UCLA researchers from the Department of Molecular, Cell, and Developmental Biology have developed stable cell lines expressing wild-type or disease-associated mutant TRPV4 channels, providing a powerful platform for mechanistic and drug discovery studies. BACKGROUND: TRPV4 is a non-selective cation channel that regulates calcium influx in response...
Published: 10/1/2025
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Inventor(s):
Daniel Cohn
Keywords(s):
Category(s):
Life Science Research Tools > Cell Lines
,
Therapeutics > Musculoskeletal Disease
,
Therapeutics > CNS and Neurology
Therapeutic Targets from Subproteomes of Astrocytes and Neurons (UCLA Case No. 2024-162)
UCLA researchers in the Department of Physiology have identified specific endogenous receptors that activate an astrocyte signaling pathway, which is beneficial for restoring astrocyte morphology and ameliorating phenotypes associated with obsessive-compulsive disorder and other brain disorders. BACKGROUND: Obsessive-compulsive disorder (OCD) is a...
Published: 10/30/2025
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Inventor(s):
Baljit Khakh
Keywords(s):
Category(s):
Therapeutics > CNS and Neurology
,
Therapeutics > Psychiatry And Mental Health
Molecular Regulation of Stroke-Resistant Neurons (UCLA Case No. 2020-937)
Researchers in the Department of Neurology at UCLA have identified pharmacologic compounds capable of crossing the blood brain barrier that dramatically promote neurite outgrowth after stroke, thereby promoting recovery. Background: A stroke occurs when the blood supply of oxygen is interrupted to the brain, preventing brain tissue from receiving oxygen...
Published: 10/8/2025
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Inventor(s):
Jason Hinman
Keywords(s):
Category(s):
Therapeutics > CNS and Neurology
Compounds that Disaggregate Alzheimer's Disease-Associated Fibrils of Tau Protein (UCLA Case No. 2022-145, 2025-329)
UCLA researchers in the Department of Biological Chemistry, Chemistry and Biochemistry developed a new tau-inhibiting seven residue peptide and conjugated it to magnetic nanoparticles for the treatment of Alzheimer’s disease. These compounds disaggregate pathogenic tau amyloid fibrils at atomic resolution, restore normal neuronal function, and...
Published: 11/19/2025
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Inventor(s):
David Eisenberg
,
Ke Hou
Keywords(s):
Category(s):
Therapeutics > CNS and Neurology
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