Search Results - gal+bitan

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A Duplex Electrochemiluminescence Immunoassay for Total α-Synuclein and PS129-α-Synuclein (UCLA Case No. 2024-132)
Synucleinopathies are a group of neurodegenerative diseases including Parkinson's disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA). These diseases are characterized by the aggregation and deposition of α-synuclein (α-syn) in Lewy bodies (LBs) in PD and DLB or as glial cytoplasmic inclusions in MSA. In...
Published: 9/15/2025   |   Inventor(s): Gal Bitan
Keywords(s):  
Category(s): Diagnostic Markers > Targets And Assays, Therapeutics > CNS and Neurology
2019-482 AN ELECTROCHEMILUMINESCENCE ELISA FOR PS129-ΑLPHA-SYNUCLEIN
UCLA researchers in the Department of Neurology have developed a novel method and assay of quantifying pS129-alpha-synuclein at high sensitivity and specificity using an electrochemiluminescence ELISA assay. BACKGROUND: Neurodegenerative diseases such as Parkinson’s disease (PD), dementia with Lewy bodies, and multiple system atrophy are all synucleinopathies,...
Published: 7/17/2025   |   Inventor(s): Gal Bitan
Keywords(s): Cns, Diagnostic Markers & Platforms, Diagnostic Platform Technologies (E.G. Microfluidics), Life Science Research Tools, Targets And Assays
Category(s): Diagnostic Markers > Targets And Assays, Platforms > Diagnostic Platform Technologies, Therapeutics > CNS and Neurology
New Molecular Tweezers Against Neurological Disorders and Viral Infections (UCLA Case No. 2018-906)
Summary UCLA researchers in the Department of Neurology with an international team of scientists have developed several new molecular tweezer derivatives with novel synthesis methods that significantly improved the therapeutic efficacy and pharmacokinetic characteristics of the drug candidates. Background Protein aggregation is critical in the...
Published: 9/15/2025   |   Inventor(s): Gal Bitan, Danielle Bouquio, Ravinder Malik, Thomas Schrader, Jan Munch, Christian Heid, Andrea Sowislok, Annika Rocker
Keywords(s): Cns, Infectious Diseases, Therapeutics & Vaccines
Category(s): Therapeutics, Therapeutics > CNS and Neurology, Therapeutics > Infectious Diseases
2018-455 Inhibition of Lipofuscin Aggregation by Molecular Tweezers
Inhibition Of Lipofuscin Aggregation By Molecular TweezersSUMMARYUCLA researchers in the Departments of Neurology and Molecular Therapy & Medical Genetics have developed a novel approach toward broad inhibition of lipofuscin aggregation.BACKGROUNDLipofuscin is an age-related pigment compound that can be found throughout the body and its aggregation...
Published: 7/17/2025   |   Inventor(s): Gal Bitan
Keywords(s): Cns, Genetic Disease, Medical Devices and Materials, Ophthalmology, Therapeutics & Vaccines
Category(s): Medical Devices, Therapeutics, Therapeutics > Ophthalmology, Therapeutics > CNS and Neurology
2018-726 TREATMENT OF LYSOSOMAL STORAGE DISORDERS
SummaryUCLA researchers in the Departments of Neurology have developed a novel treatment for Lysosomal-storage diseases (LSDs) with neurological impairment.BackgroundLysosomal-storage diseases (LSDs) cause abnormal accumulation and aggregation of proteins due to insufficient clearance of proteins by the lysosomes. Although individually rare, LSDs as...
Published: 7/17/2025   |   Inventor(s): Gal Bitan, Alessandro Fraldi, Antonio Monaco, Irene Sambri
Keywords(s): Cns, Therapeutics & Vaccines
Category(s): Therapeutics, Therapeutics > CNS and Neurology