Search Results - therapeuticarea+%3e+neurology

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Fluorinated MU-Opioid Receptor Agonists
Summary: Investigators at the National Institute on Drug Abuse seek co-development partners and/or licensees for collection of mu opioid receptor (MOR) agonists as alternatives for existing compounds. Description of Technology: Although existing opioids are excellent analgesics and useful as positron emission tomography (PET) radiotracers, they come...
Published: 12/20/2024   |   Inventor(s): Michael Michaelides, Juan Gomez, Kenner Rice, Agnieszka Sulima, Michael Baumann
Keywords(s):  
Category(s): Application, Application > Therapeutics, Collaboration Sought > Collaboration, TherapeuticArea > Immunology, TherapeuticArea > Neurology, TherapeuticArea > Radiology, Collaboration Sought > Licensing
Suppression Of Uveitis By A STAT3 Single Domain Antibody
Summary: The National Eye Institute seeks research co-development partners and/or licensees for a STAT3 antibody that can suppress uveitis. Description of Technology: Uveitis is caused by inflammation in the eye that causes pain and reduce vision in affected patients. Rates of uveitis in the United States occurs 1 in every 200 people with eye-related...
Published: 12/23/2024   |   Inventor(s): Charles Egwuagu, Sunanda Singh
Keywords(s):  
Category(s): Application, Application > Therapeutics, Collaboration Sought > Collaboration, TherapeuticArea > Neurology, TherapeuticArea > Ear, Nose, & Throat, Collaboration Sought > Licensing
Single Source-Detector Separation Approach to Calculate Tissue Oxygen Saturation
Summary: The National Institute of Child Health and Human Development (NICHD) seeks partners and/or licensees to further develop and commercialize the miniaturized tissue oximeter for implementing the single source-detector separation algorithm in existing devices/systems to collect tissue oxygen saturation. Description of Technology: Tissue oxygen...
Published: 12/20/2024   |   Inventor(s): Thien Nguyen, Amir Gandjbakhche, Soongho Park, Brian Hill
Keywords(s):  
Category(s): Application > Medical Devices, TherapeuticArea > Respiratory, TherapeuticArea > Neurology, TherapeuticArea > Infectious Disease, Collaboration Sought > Collaboration, Collaboration Sought > Licensing
Interleukin-27 Producing B-Cell Population and Uses Thereof
Summary: The National Eye Institute (NEI) seeks research co-development partners and/or licensees to advance the production and uses of interleukin-27 (IL-27) producing B-regulatory cell (i27-Breg) therapy for immune related autoimmune disorders. These disorders include but are not limited, to age-related macular degeneration (AMD), graft-versus-host...
Published: 12/20/2024   |   Inventor(s): Charles Egwuagu, Jin Choi
Keywords(s):  
Category(s): Application > Therapeutics, Collaboration Sought > Collaboration, TherapeuticArea > Neurology, TherapeuticArea > Immunology, TherapeuticArea > Ear, Nose, & Throat, Collaboration Sought > Licensing
PET Imaging of lntegrin Expression with Suitably Labeled RGD Peptides for Multiple Diagnostic Purposes
This technology includes a number of dimeric RGD peptides which been developed and labeled with various PET isotopes (1BF, 68Ga, and 64Cu) for imaging integrin expression in cancer, inflammation, rheumatoid arthritis, myocardial infarct, stroke and traumatic injury. A number of these peptides have been translated into clinic for diagnosis and therapy...
Published: 8/12/2024   |   Inventor(s): Xiaoyuan (Shawn) Chen, Lixin Lang, Gang NIU
Keywords(s):  
Category(s): Application > Diagnostics, Application > Research Materials, Collaboration Sought > Licensing, ResearchProducts > Research Equipment, TherapeuticArea > Cardiology, TherapeuticArea > Immunology, TherapeuticArea > Neurology
Real-time Monitoring of In Vivo Free Radical Scavengers Through Hyperpolarized [1-13C] N-acetyl Cysteine as a Diagnostic and Disease Monitoring Tool
This technology includes synthesized demonstrated [1-13C] NAC as a promising novel probe for hyperpolarized 13C MRI methodologies which could provide diagnostic, and evaluation of response to treatment in various cancers and neurological diseases. N-acetyl cysteine (NAC) is a widely used therapeutic and involved to stimulate glutathione synthesis. Glutathione...
Published: 8/12/2024   |   Inventor(s): Murali Cherukuri, Rolf Swenson, Kazutoshi Yamamoto, Ana Opina
Keywords(s):  
Category(s): Application > Diagnostics, Application > Research Materials, Collaboration Sought > Licensing, TherapeuticArea > Neurology, TherapeuticArea > Oncology
Generation of Gene Specific Targeting Donor Plasmid (p5KI-GP-CHN and p3KI-GP-CHN)
This technology includes the use of engineered human induced pluripotent stem cells (iPSCs) for various applications such as studying cell differentiation, drug screening, and gene transfer therapy. It employs gene targeting donors flanked by DNA sequences compatible with endogenous loci to integrate transgenes through homologous recombination. A key...
Published: 9/10/2024   |   Inventor(s): Jizhong Zou, Mahendra Rao
Keywords(s):  
Category(s): Application > Research Materials, Collaboration Sought > Licensing, ResearchProducts > Human iPSC Lines, TherapeuticArea > Neurology
Astrocyte Differentiation of Neural Stem Cells with StemPro Embryonic Stem Cell Serum Free Medium for Research and Potential Therapeutic Use
This technology includes an innovative method for differentiating astrocytes from neural stem cells (NSCs). The process involves using Life Technologies StemPro embryonic stem cell serum-free medium to initially guide NSCs towards a neuronal lineage. Over a period of 28-35 days, as the cells are continually passaged, neurons gradually die off, leading...
Published: 9/10/2024   |   Inventor(s): Nasir Malik, Mahendra Rao, Xianmin Zeng
Keywords(s):  
Category(s): Application > Research Materials, Collaboration Sought > Materials Available, ResearchProducts > Human Cell Lines, TherapeuticArea > Neurology
Neural Stem Cells from an iPSC Line Ubiquitously Expressing Green Fluorescent Protein for Basic Science Research and Cell Line Tracking
This technology involves neural stem cells (NSCs) derived from pluripotent stem cells (PSCs) that can differentiate into neurons and glia. The key feature of this technology is the CY2 EEF1A1 GFP iPSC line, which includes a green fluorescent protein (GFP) expressed under the EEF1A1 promoter, leading to its ubiquitous expression in cells. This characteristic...
Published: 9/10/2024   |   Inventor(s): Nasir Malik, Mahendra Rao
Keywords(s):  
Category(s): Application > Research Materials, Collaboration Sought > Materials Available, ResearchProducts > Human Cell Lines, TherapeuticArea > Neurology
A Neural Stem Line from a Niemann Pick C (NPC) Type 1 Patient for Therapy Development
This technology includes a neural stem cell (NSC) line derived from a Niemann Pick C (NPC) patient, aimed at advancing research and drug development for NPC, an inherited neurodegenerative disorder characterized by the accumulation of cholesterol in neurons. The NSCs, which serve as a crucial intermediate cell type, can be differentiated into any neuronal...
Published: 8/12/2024   |   Inventor(s): Nasir Malik
Keywords(s):  
Category(s): Application > Research Materials, Collaboration Sought > Materials Available, ResearchProducts > Human Cell Lines, TherapeuticArea > Metabolic Disease, TherapeuticArea > Neurology
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