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MEPicides: Novel DXR Inhibitors for Drug-Resistant Malaria and Tuberculosis
Malaria and tuberculosis, caused by Plasmodium spp. and Mycobacterium tuberculosis respectively, continue to pose global health challenges with an estimated 429,000 deaths annually. While efforts have been underway to develop drugs targeting the causative agents behind these diseases, the rise of drug resistance strains of these pathogens has limited...
Published: 10/29/2024   |   Inventor(s): Cynthia Dowd, Darean Bague, Ruiqin Wang, Audrey Odom, Robin Couch, Helena Boshoff
Keywords(s):  
Category(s): Technology Classifications > Therapeutics > Small Molecules
Novel Combination Immunotherapy Targeting CD47-SIRPα Axis and HDAC6 Inhibition
Recent advances in cancer therapy have increasingly focused on harnessing the body's immune system to combat cancer cells. Histone deacetylases (HDACs) play a critical role in the epigenetic regulation of gene expression by remodeling chromatin. HDAC inhibitors are recognized for their ability to induce cancer cell cycle arrest, differentiation,...
Published: 8/19/2024   |   Inventor(s): Alejandro Villagra, Maria del Mar Gracia Hernandez
Keywords(s):  
Category(s): Technology Classifications > Therapeutics > Small Molecules
Combating Opioid-Induced Respiratory Depression Using Setmelanotide
The opioid crisis is a serious public health crisis in the United States. Mortality from opioid overdose increased by roughly ten times from 1999 to 2021. The primary cause of death is due to opioid-induced respiratory depression (OIRD). Currently, Naloxone and Nalmefene are actively used to reverse OIRD in emergency settings and by first responders....
Published: 7/30/2024   |   Inventor(s): Vsevolod Polotsky, David Mendelowitz, O Aung, Mateus Ramos Amorim, Joan Escobar
Keywords(s):  
Category(s): Technology Classifications > Therapeutics > Small Molecules, Technology Classifications > Therapeutics > Repurposed Drugs
A Small Molecule Inhibitor Selective for HDAC11
­HDAC11 is an enzyme which belongs to the Histone Deacetylase (HDAC) class of enzymes. However, HDAC11 has a high defatty-acylase activity while its deacetylation activity is virtually nonexistent. The defatty-acylase activity of HDAC11 is linked to increased interferon I signaling, suggesting that inhibition of HDAC11 can be used to treat diseases...
Published: 8/6/2024   |   Inventor(s): Edward Seto, Hening Lin, Thanh Ho
Keywords(s):  
Category(s): Technology Classifications > Therapeutics > Small Molecules
Butyrate Derivatives for Use in the Rescue Of Mitochondrial Diseased Phenotype and Dysfunction of Patient-Derived Cells
­Mitochondrial respiratory disorders (MRDs) are incurable progressive degenerative diseases resulting from malfunction of mitochondria, which are responsible to generate ATP via the oxidative phosphorylation (OXPHOS) system. One of the most frequent pediatric MRDs is MELAS (Mitochondrial Encephalopathy with Lactic Acidosis and Stroke-like episodes)....
Published: 7/30/2024   |   Inventor(s): Anne Chiaramello, Martine Uittenbogaard
Keywords(s):  
Category(s): Technology Classifications > Therapeutics > Small Molecules
Potent And-1 Inhibitors that Suppress Tumor Growth and Overcome Platinum Drug Resistance
­Ovarian cancer (OC) is one of the leading causes of cancer-related deaths in women. The survival rate of ovarian cancer patients is low largely due to platinum-based chemotherapy resistance and lack of alternative regimens. Recent studies showed that the Acidic nucleoplasmic DNA-binding protein 1 (And-1) activation promotes platinum drug resistance...
Published: 7/30/2024   |   Inventor(s): Wenge Zhu, Yiliang Li, Jing Li
Keywords(s):  
Category(s): Technology Classifications > Therapeutics > Small Molecules
SENP1 Enzymatic Activity Inhibitors for Platinum Resistant Ovarian Cancer
­Ovarian cancer is one of the leading causes of cancer-related deaths in women. The survival rate of ovarian cancer patients is low largely due to platinum-based chemotherapy resistance and lack of alternative regimens. A recent study indicated that Janus tyrosine kinase 2 (JAK2), which activates the signal transducers and activators of transcription...
Published: 7/30/2024   |   Inventor(s): Wenge Zhu, Jing Li, Ruiqin Wu, Yiliang Li
Keywords(s):  
Category(s): Technology Classifications > Therapeutics > Small Molecules
Anti-inflammatory adoptive cell therapy using macrophages for enhanced tissue regeneration and wound healing
Patients dealing with organ transplants, autoimmune disorders, chronic wounds, ischemic injury, and other diseases that trigger inflammatory processes often lack effective treatment strategies. Macrophages are key cellular components of innate immunity with varying impacts on inflammation. M1 macrophages are pro-inflammatory, while M2 macrophages are...
Published: 9/11/2024   |   Inventor(s): Alejandro Villagra, Satish kumar Noonepalle, Maria del Mar Gracia Hernandez, Brett Shook
Keywords(s):  
Category(s): Technology Classifications > Therapeutics > Small Molecules
In vitro drug treatment to proliferate and activate effector cells for immunotherapy
­STAT5 SUMOylation inhibition increases CD4 and CD8 T-cell proliferation and and production of immune effector molecules in CD8 T-cells and NK (natural killer) cells. Both attributes address critical limiting factors in applying cell therapies to fighting cancers and pathogens. The difficulty of obtaining enough activated effector cells limits the...
Published: 9/11/2024   |   Inventor(s): Alberto Bosque-Pardos, Amanda Beatriz Rodrigues Barreto de Macedo, Eric Sorensen, Vicente Planelles
Keywords(s):  
Category(s): Technology Classifications > Therapeutics > Small Molecules
Antibiotic for Veterinary Staphylococcal Infections
­New bacteriostatic compounds treat Staphylococcal strains that infect bovine, cat, and dog populations. Staphylococcal infections affect an estimated 20% of bovine populations in the dairy industry, and are the single largest indication for antibiotic use on dairy farms. Staphylococcal infections lead to a cost of greater than $1 billion per year...
Published: 9/11/2024   |   Inventor(s): Cynthia Dowd, Audrey Odom, Rachel Edwards, Kenneth Heidel, Xu "Jack" Wang, Rene Chofor
Keywords(s):  
Category(s): Technology Classifications > Therapeutics > Small Molecules
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