Search Results - alejandro+villagra

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HDAC6i-Activated Macrophage Cell Therapy
­The tumor microenvironment (TME) plays a key role in tumor growth and survival. Often the immunosuppressive nature of the TME prevents success of treatments including immune checkpoint blockade (ICB), radiation therapy (RT), and chemotherapy. Macrophages in the TME contribute to its immunosuppressive or immunostimulatory character. M2 macrophages...
Published: 11/19/2024   |   Inventor(s): Alejandro Villagra, Nima Aghdam, Satish kumar Noonepalle
Keywords(s):  
Category(s): Technology Classifications > Therapeutics > Cells
STAT-Activated Macrophages for Targeted Cancer Immunotherapy
Macrophages play a critical role in both innate and adaptive immunity, essential for maintaining tissue homeostasis and combating infections. In the context of cancer, macrophages can differentiate into two main phenotypes: M1 macrophages, which exhibit anti-tumor properties, and M2 macrophages, which support tumor progression and contribute to anti-inflammatory...
Published: 11/19/2024   |   Inventor(s): Alejandro Villagra, Satish kumar Noonepalle, Maria del Mar Gracia Hernandez
Keywords(s):  
Category(s): Technology Classifications > Therapeutics > Cells
Novel Combination Immunotherapy Targeting CD47-SIRPα Axis and HDAC6 Inhibition
Recent advances in cancer therapy have increasingly focused on harnessing the body's immune system to combat cancer cells. Histone deacetylases (HDACs) play a critical role in the epigenetic regulation of gene expression by remodeling chromatin. HDAC inhibitors are recognized for their ability to induce cancer cell cycle arrest, differentiation,...
Published: 8/19/2024   |   Inventor(s): Alejandro Villagra, Maria del Mar Gracia Hernandez
Keywords(s):  
Category(s): Technology Classifications > Therapeutics > Small Molecules
Anti-inflammatory adoptive cell therapy using macrophages for enhanced tissue regeneration and wound healing
Patients dealing with organ transplants, autoimmune disorders, chronic wounds, ischemic injury, and other diseases that trigger inflammatory processes often lack effective treatment strategies. Macrophages are key cellular components of innate immunity with varying impacts on inflammation. M1 macrophages are pro-inflammatory, while M2 macrophages are...
Published: 9/11/2024   |   Inventor(s): Alejandro Villagra, Satish kumar Noonepalle, Maria del Mar Gracia Hernandez, Brett Shook
Keywords(s):  
Category(s): Technology Classifications > Therapeutics > Small Molecules