Search Results - wenge+zhu

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Potent And-1 Inhibitors that Suppress Tumor Growth and Overcome Platinum Drug Resistance
­Ovarian cancer (OC) is one of the leading causes of cancer-related deaths in women. The survival rate of ovarian cancer patients is low largely due to platinum-based chemotherapy resistance and lack of alternative regimens. Recent studies showed that the Acidic nucleoplasmic DNA-binding protein 1 (And-1) activation promotes platinum drug resistance...
Published: 7/30/2024   |   Inventor(s): Wenge Zhu, Yiliang Li, Jing Li
Keywords(s):  
Category(s): Technology Classifications > Therapeutics > Small Molecules
SENP1 Enzymatic Activity Inhibitors for Platinum Resistant Ovarian Cancer
­Ovarian cancer is one of the leading causes of cancer-related deaths in women. The survival rate of ovarian cancer patients is low largely due to platinum-based chemotherapy resistance and lack of alternative regimens. A recent study indicated that Janus tyrosine kinase 2 (JAK2), which activates the signal transducers and activators of transcription...
Published: 7/30/2024   |   Inventor(s): Wenge Zhu, Jing Li, Ruiqin Wu, Yiliang Li
Keywords(s):  
Category(s): Technology Classifications > Therapeutics > Small Molecules
And-1 Inhibition by DHS for Cancer Treatment
­GW researchers developed DHS (4,4’-trans-dihydroxystilbene) as a new cytotoxic anticancer drug for use alone or in combination with other chemotherapies. Drug toxicity and drug resistance limit the ability of many cytotoxic cancer drugs to effectively treat cancer, a problem which is overcome by DHS. The cancer killing efficacy of DHS is...
Published: 9/11/2024   |   Inventor(s): Chi-Wei Chen, Zhiyong Han, Wenge Zhu, Yongming Li
Keywords(s):  
Category(s): Technology Classifications > Therapeutics > Small Molecules
Digital Sensing Device for Direct Signal Processing (2017-009)
The growing need for quick and easy methods of assessing, analyzing, and storing data of various kinds has increased exponentially in the past several years. In terms of gathering data on parameters such as temperatures, pressures, and humidity levels a sensor with wires and external sources of power are often required. Clemson University researchers...
Published: 10/8/2024   |   Inventor(s): Hai Xiao, Wenge Zhu
Keywords(s):  
Category(s): Information and Communication Technology