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Search Results - technology+classifications+%3e+research+tools%2fcopyright+%3e+animal+models
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Conditional Hs3st1/4/5 Mouse Lines for In-vivo Study of Heparan Sulfate (HS)
Advantages: Cell and Stage-specific Cre-loxP mediated ablation of Hs3st1/4/5 First-ever floxed alleles for Hs3st4 and Hs3st5 Captures complex neurological and behavioral phenotypes Evaluates drugs on HS pathways and 3-O-sulfation dependent motifs Summary: Heparan sulfate (HS) is a polysaccharide which plays a vital role in various biological...
Published: 6/26/2025
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Inventor(s):
Lianchun Wang
Keywords(s):
Animal Models
,
Neuroscience
Category(s):
Technology Classifications > Research Tools/Copyright > Animal Models
,
Technology Classifications > Medical > Neuroscience
Mouse Model for Direct Visualization of Endothelial Permeability in Disease States: Cdh5-mScarlet Reporter Mouse
Advantages Reporter mouse reliable labels VE-cadherin, replacing the need for difficult immunostaining protocols enables quicker, live, longitudinal imaging of VE-cadherin remodeling and vascular permeability in vivo Far-red mScarlet emission enables clearer deep-tissue imaging and real time quantification of VE-cadherin turnover and junctional...
Published: 6/4/2025
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Inventor(s):
Joshua Scallan
Keywords(s):
Animal Models
Category(s):
Technology Classifications > Research Tools/Copyright > Animal Models
A novel mouse model (TRE-HuAmy line) to achieve spatial and temporal control of human amylin transgene expression
Advantages Enables the in vivo switching on or off human amylin expression through the administration/ withdrawal of DOX Spatially restricted transgene activation: crossing tissue-specific rtTA/tTA lines achieves localized amylin expression without off-target effects. Single-copy Rosa26 knock-in for consistent expression: integration at Rosa26...
Published: 6/3/2025
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Inventor(s):
Gopal Thinakaran
,
Florin Despa
Keywords(s):
Category(s):
Technology Classifications > Research Tools/Copyright > Animal Models
,
Technology Classifications > Medical > Neuroscience
,
zzDiabetes
RNA Binding Motif 3 (RBM3) Overexpressing Transgenic Mouse
Advantages • RBM3 upregulation reverses multiple tau phosphorylations post-TBI • Novel RBM3 Overexpressing Transgenic Mouse Model allows researchers to study the effects of RBM3 activation on tissue function, brain function, and brain injury Summary Traumatic brain injury (TBI) not only causes immediate neuronal damage but also...
Published: 5/30/2025
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Inventor(s):
Travis Jackson
Keywords(s):
Animal Models
,
Neuroscience
Category(s):
Technology Classifications > Research Tools/Copyright > Animal Models
,
Technology Classifications > Medical > Neuroscience
,
Technology Classifications > Medical > Biotechnology
Transgenic Foxc2-tdTomato Overexpressing Mouse Model for Study and Screening of Lymphatic Valve Development
Advantages Tissue specific Foxc2 expression with integrated tdTomato fluorescent reporter enables precise spatiotemporal visualization Enables monitoring of lymphatic valve development 1:1 co-expression of Foxc2 and tdTomato, overcoming expression variability characteristic associated with of IRES-based or viral delivery systems Single-vector...
Published: 5/30/2025
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Inventor(s):
Joshua Scallan
Keywords(s):
Animal Models
Category(s):
Technology Classifications > Research Tools/Copyright > Animal Models
BAC Transgenic Prox1CreERT2 Mouse Line: Allows for Deletion of 'Floxed' Genes Specifically in the Lymphatic Vasculature
Advantages Distinct BAC backbone allows for transgene integration on a separate chromosome, avoiding linkage and complex breeding schemes observed in current strains. Demonstrates >90% Cre-mediated excision in Prox1+ lymphatic endothelial cells, outperforming previous models which demonstrate ~60-70%. Restricts recombination to lymphatic vasculature...
Published: 5/29/2025
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Inventor(s):
Joshua Scallan
Keywords(s):
Animal Models
Category(s):
Technology Classifications > Research Tools/Copyright > Animal Models
Mouse Models for Studying Hyperglycemia-induced Hyperfiltration via NOS1 and NKCC2 Proteins (NOS1Cre / NKCC2ftox / NOS1Cre-NKCC2ftox Mice)
Advantages Future applications for treatment of diabetic nephropathy Three mouse models for utilization in diabetic research Defined mechanism behind glomerular hyperfiltration Summary Our inventors have discovered a novel mechanism of hyperglycemia-induced hyperfiltration via the NOS1 and NKCC2 proteins within the body. By increasing the level...
Published: 6/10/2025
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Inventor(s):
Ruisheng Liu
Keywords(s):
Animal Models
Category(s):
Technology Classifications > Research Tools/Copyright > Animal Models
Mouse Models for Studying Hyperglycemia-induced Hyperfiltration via NOS1 and NKCC2 Proteins (NOS1Cre / NKCC2ftox / NOS1Cre-NKCC2ftox Mice)
Advantages Future applications for treatment of diabetic nephropathy Three mouse models for utilization in diabetic research Defined mechanism behind glomerular hyperfiltration Summary: Our inventors have discovered a novel mechanism of hyperglycemia-induced hyperfiltration via the NOS1 and NKCC2 proteins within the body. By increasing the level...
Published: 6/10/2025
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Inventor(s):
Ruisheng Liu
Keywords(s):
Animal Models
Category(s):
Technology Classifications > Research Tools/Copyright > Animal Models
Animal Model of Angelman Syndrome
Advantages: Lacks the entire UBE3 gene Removal of all isoforms Removal of all alternate promoters Summary: Angelman Syndrome (AS) is a devastating neurological disorder which affects 1 in every 15,000 people. AS presents with ataxia, frequent smiling, laughter, lack of speech, and severe, debilitating seizures. Epilepsy in AS is often refractory...
Published: 5/12/2025
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Inventor(s):
Edwin Weeber
,
David Segal
,
Hennriette O'Geen
,
Ben Pyles
,
Scott Dindot
Keywords(s):
Animal Models
Category(s):
Technology Classifications > Research Tools/Copyright > Animal Models
,
Technology Classifications > Medical
,
Technology Classifications > Medical > Neuroscience
The Sudden Head Acceleration & Kinetic Encephalopathy (SHAKEn™) Device for Preclinical Modeling of Rotational Brain Injury
Advantages: User control to adjust the positioning of the body plate (in the x/y plane) to optimize spinal alignment relative to the axis of rotation prior to insult. An aeronautics-grade angular rate sensor for direct measurement of angular velocity and to calculate rotational acceleration of the head. An electric plug to power accelerations...
Published: 7/18/2024
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Inventor(s):
Travis Jackson
Keywords(s):
Animal Models
,
Lab Apparatus
,
Laboratory Devices
,
Neuroscience
,
Research Tools
Category(s):
Technology Classifications > Research Tools/Copyright > Animal Models
,
Technology Classifications > Medical > Biomedical Engineering
,
Technology Classifications > Medical > Medical Devices
,
Technology Classifications > Medical > Neuroscience
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