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BAC Transgenic Prox1CreERT2 Mouse Line: Allows for Deletion of 'Floxed' Genes Specifically in the Lymphatic Vasculature
Advantages Distinct BAC backbone allows for transgene integration on a separate chromosome, avoiding linkage and complex breeding schemes observed in current strains. Demonstrates >90% Cre-mediated excision in Prox1+ lymphatic endothelial cells, outperforming previous models which demonstrate ~60-70%. Restricts recombination to lymphatic vasculature...
Published: 5/29/2025   |   Inventor(s): Joshua Scallan
Keywords(s): Animal Models
Category(s): Technology Classifications > Research Tools/Copyright > Animal Models
Mouse Models for Studying Hyperglycemia-induced Hyperfiltration via NOS1 and NKCC2 Proteins (NOS1Cre / NKCC2ftox / NOS1Cre-NKCC2ftox Mice)
Advantages Future applications for treatment of diabetic nephropathy Three mouse models for utilization in diabetic research Defined mechanism behind glomerular hyperfiltration Summary Our inventors have discovered a novel mechanism of hyperglycemia-induced hyperfiltration via the NOS1 and NKCC2 proteins within the body. By increasing the level...
Published: 5/28/2025   |   Inventor(s): Ruisheng Liu
Keywords(s): Animal Models
Category(s): Technology Classifications > Research Tools/Copyright > Animal Models
Mouse Models for Studying Hyperglycemia-induced Hyperfiltration via NOS1 and NKCC2 Proteins (NOS1Cre / NKCC2ftox / NOS1Cre-NKCC2ftox Mice)
Advantages Future applications for treatment of diabetic nephropathy Three mouse models for utilization in diabetic research Defined mechanism behind glomerular hyperfiltration Summary: Our inventors have discovered a novel mechanism of hyperglycemia-induced hyperfiltration via the NOS1 and NKCC2 proteins within the body. By increasing the level...
Published: 5/28/2025   |   Inventor(s): Ruisheng Liu
Keywords(s): Animal Models
Category(s): Technology Classifications > Research Tools/Copyright > Animal Models
Animal Model of Angelman Syndrome
Advantages: Lacks the entire UBE3 gene Removal of all isoforms Removal of all alternate promoters Summary: Angelman Syndrome (AS) is a devastating neurological disorder which affects 1 in every 15,000 people. AS presents with ataxia, frequent smiling, laughter, lack of speech, and severe, debilitating seizures. Epilepsy in AS is often refractory...
Published: 5/12/2025   |   Inventor(s): Edwin Weeber, David Segal, Hennriette O'Geen, Ben Pyles, Scott Dindot
Keywords(s): Animal Models
Category(s): Technology Classifications > Research Tools/Copyright > Animal Models, Technology Classifications > Medical, Technology Classifications > Medical > Neuroscience
The Sudden Head Acceleration & Kinetic Encephalopathy (SHAKEn™) Device for Preclinical Modeling of Rotational Brain Injury
­Advantages: User control to adjust the positioning of the body plate (in the x/y plane) to optimize spinal alignment relative to the axis of rotation prior to insult. An aeronautics-grade angular rate sensor for direct measurement of angular velocity and to calculate rotational acceleration of the head. An electric plug to power accelerations...
Published: 7/18/2024   |   Inventor(s): Travis Jackson
Keywords(s): Animal Models, Lab Apparatus, Laboratory Devices, Neuroscience, Research Tools
Category(s): Technology Classifications > Research Tools/Copyright > Animal Models, Technology Classifications > Medical > Biomedical Engineering, Technology Classifications > Medical > Medical Devices, Technology Classifications > Medical > Neuroscience
Conditional FKBP51 Over-expression Transgenic Mouse
­Advantages: Created a transgenic mice model that allows researchers to precisely control the expression of human FKBP51. Offers a tailored approach to studying psychiatric disorders, enabling the development of personalized treatments. Enhances the understanding of the molecular mechanisms underlying psychiatric disorders such as depression,...
Published: 11/13/2024   |   Inventor(s): Chad Dickey(VA) (DECEASED - See Notes), Laura Blair, Bo Zhang
Keywords(s): Animal Models, Psychiatry / Mental Health
Category(s): Technology Classifications > Research Tools/Copyright > Animal Models, Technology Classifications > Medical > Biotechnology, Technology Classifications > Medical > Biomedical Engineering, Technology Classifications > Medical > Medical Diagnostics, Technology Classifications > Medical > Neuroscience, Technology Classifications > Medical > Pharmaceuticals, Technology Classifications > Medical > Therapeutics
: Mouse Models for Studying Hyperglycemia-induced Hyperfiltration via NOS1 and NKCC2 Proteins (NOS1Cre / NKCC2ftox / NOS1Cre-NKCC2ftox Mice)
Competitive Advantages Future applications for treatment of diabetic nephropathy Three mouse models for utilization in diabetic research Defined mechanism behind glomerular hyperfiltration Summary Our inventors have discovered a novel mechanism of hyperglycemia-induced hyperfiltration via the NOS1 and NKCC2 proteins within the body. By increasing...
Published: 5/28/2025   |   Inventor(s): Ruisheng Liu
Keywords(s): Diabetes, Laboratory Methods
Category(s): Technology Classifications > Medical, Technology Classifications > Research Tools/Copyright > Animal Models, Technology Classifications > Research Tools/Copyright