Search Results - technology+classifications+%3e+antibodies

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mAbs Inhibit Human RAGE by Blocking Its Binding to Heparan Sulfate

Monoclonal antibodies that block heparan sulfate binding to human RAGE, preventing its activation in disease states to serve as a therapeutic treatment. Background: Receptor for Advanced Glycation End products (RAGE), a widely expressed inflammatory receptor for disease states such as atherosclerosis, cancer, Alzheimer disease, drug-induced liver...

Published: 7/9/2024 | Inventor(s): Ding Xu, Chih Yean Ong, Miaomiao Li

Keywords(s): Featured, Technologies

Category(s): Campus > University at Buffalo, Technology Classifications > Antibodies, Technology Classifications > Therapeutics and Vaccines

Compositions and Methods for Increased Circulation Half-Life

Single domain antibody composition that enable half-life extension and increased blood:tissue ratios. Background: While strategies such as PEGylation (PEG, polyethylene glycol), albumin binding, and Fc-fusion have been employed to extend the half-life of biological and pharmaceutical agents, there remains a need for additional strategies that not...

Published: 2/2/2024 | Inventor(s): Brandon Bordeau, Joseph Balthasar, Toan Nguyen

Keywords(s): Featured, Technologies

Category(s): Campus > University at Buffalo, Technology Classifications > Antibodies, Technology Classifications > Therapeutics and Vaccines

IgA Monoclonal Antibodies as a Prophylactic and Therapeutic Treatment for Dengue Virus Infection

Enables the prevention and treatment of dengue by avoiding the challenge of Antibody Dependent Enhancement. Background: Dengue virus is one of the most widespread vector-borne viral pathogens in the world. Nearly 400 million dengue virus infections occur each year, resulting in approximately 20,000 deaths. In addition, dengue-associated illness comprises...

Published: 7/11/2023 | Inventor(s): Adam Waickman, Adam Wegman

Keywords(s): antibody, antibody therapy, biologics, biomedical, disease prevention, immunotherapy, monoclonal antibody, Technologies, viral immunology, viral pathogenesis

Category(s): Technology Classifications > Therapeutics and Vaccines, Technology Classifications > Antibodies, Technology Classifications > Healthcare, Technology Classifications > Viral Vectors, Campus > Upstate Medical University

Drug Discovery Based on Surface-Enhanced Raman Spectroscopy (SERS)

Enables drug discovery without introducing modifications to the molecules, while lowering costs by requiring only small amounts of the tested molecules. Background: Surface-enhanced Raman spectroscopy (SERS) is a novel, label-free, sensitive, specific, fast, and relatively inexpensive tool for drug discovery. It offers the potential to detect and...

Published: 3/12/2024 | Inventor(s): Igor Lednev, Lamyaa Almehmadi, Jia Sheng

Keywords(s): Raman spectroscopy, RNA, RNA chemistry, TAF, Technologies

Category(s): Campus > University at Albany, Technology Classifications > Antibodies, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Drug Delivery, Technology Classifications > Healthcare, Technology Classifications > Therapeutics and Vaccines

Antibody Against Inositol 1,4,5-Trisphosphate Receptor Type 2 (anti-IP3R antibody)

Antibody against the inositol 1,4,5-trisphosphate (IP3) receptor (IP3R) type 2 Background: The inositol 1,4,5-trisphosphate receptor type 2 (IP3R2) is an intracellular Ca²⁺-release channel located on the endoplasmic reticulum (ER). IP3R2 is characterized by a high sensitivity to both IP3 and ATP and is biphasically regulated by Ca²⁺. Furthermore,...

Published: 1/3/2024 | Inventor(s): Richard Wojcikiewicz

Keywords(s): antibodies, antibody

Category(s): Technology Classifications > Antibodies, Campus > Upstate Medical University

Easily Produced Nanoscale Hot Spots for More Sensitive Raman Scattering Using Liquid Metal Structures

A novel nanophotonic sensor that enhances Raman scattering signals by several orders of magnitude by creating nanoscale hot spots formed by liquid metal. Background: Analytes in the hot spots of such nanophotonic sensors will experience drastically enhanced interactions with the incident light, and therefore produce much more optical sensing signals....

Published: 7/9/2024 | Inventor(s): Peter Liu, Xianglong Miao, Shreyan Datta

Keywords(s): Featured, Technologies

Category(s): Campus > University at Buffalo, Technology Classifications > Antibodies, Technology Classifications > Biomedical Science and Engineering

Targeted Delivery of Matrix-Modulating Enzymes

For enhanced monoclonal antibody uptake and distribution in solid tumors. Background: Penetration of anti-tumor therapies is often limited by the tumor microenvironment, which can include a high density of extracellular matrix as well as elevated interstitial fluid pressure, both of which create a barrier to distribution. It is well established...

Published: 9/3/2024 | Inventor(s): Joseph Balthasar, Brandon Bordeau

Keywords(s): Technologies

Category(s): Technology Classifications, Technology Classifications > Antibodies, Technology Classifications > Therapeutics and Vaccines, Campus > University at Buffalo

A New Bioorthogonal Reaction

A fast, stable, versatile biomolecule coupling technology based on a bioorthogonal reaction that can occur at neutral pH and room temperature Background: “Click Chemistry” reactions are high yielding, wide in scope, create only byproducts that can be removed without chromatography, simple to perform, and can be conducted in easily removable...

Published: 7/13/2022 | Inventor(s): Susan Bane Tuttle, Özlem Dilek, Kamalika Mukherjee

Keywords(s): #SUNYresearch, Technologies

Category(s): Technology Classifications > Research Tools and Reagents, Technology Classifications > Screens and Assays, Technology Classifications > Antibodies, Campus > Binghamton University