Search Results - neuroscience%2fpain

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Small Molecule Compound to Treat Neurological Diseases
Application NMDAR agents for the treatment of various neurological diseases. Key Benefits Exemplary compound EU1180-490 is a potent and selective potentiator of GluN1/GluN3 NMDARs. The compound has excellent Lipinski drug-like properties including low molecular weight and cLogP, as well as water solubility. The initial studies have determined...
Published: 7/30/2024   |   Inventor(s): Dennis Liotta, Stephen Traynelis, Hongjie Yuan, Matthew Epplin, Samantha Summer, David Menaldino, Leon Jacobs, Adam McCallum
Keywords(s): Neuroscience/Pain, Small Molecule
Category(s): TechPub Algolia > Drug Discovery, TechPub Algolia > Therapeutics
SPIRIT Intervention Training Manual And SPIRIT Intervention Guide
Application Training manual and intervention guide designed for care providers of dementia patients to promote patients’ and their family caregivers’ decision-making regarding end-of-life care. Key Benefits Helps patients and their family caregivers prepare for end-of-life decision making. Provides training and intervention guide for...
Published: 7/30/2024   |   Inventor(s): Mi-Kyung Song
Keywords(s): Education & Training, Neuroscience/Pain
Category(s): TechPub Algolia > Non-Therapeutics
Strategy to Identify miRNAs for Disease Diagnosis
Application Method to measure precursor and mature miRNA specifically. Key Benefits Unique primers can specifically identify miRNAs and precursor miRNAs by standard qRT-PCR without the requirement for an additional detection probe. Allows for amplification and quantification of both mature miRNA and precursor miRNAs. Potential technology to evaluate...
Published: 9/26/2024   |   Inventor(s): Wenming Li
Keywords(s): Enzyme/Protein, Neuroscience/Pain, Oncology
Category(s): TechPub Algolia > Research Tools
Psychosis Prediction Using Speech Patterns
Application Linguistic software to predict and diagnose psychosis. Key Benefits New method of diagnosing psychosis. Very high accuracy rate (86.7%). Market Summary Psychotic disorders are mental illnesses characterized by delusions, hallucinations, and disorganized thinking and speaking. Schizophrenia is an example of a psychotic disorder....
Published: 7/30/2024   |   Inventor(s): Phillip Wolff, Jinho Choi
Keywords(s): Artificial Intelligence, Neuroscience/Pain, Research Study Tools
Category(s): TechPub Algolia > Software, TechPub Algolia > Diagnostics, TechPub Algolia > Research Tools
ADGRB3/BAI3 Knockout Mouse
ApplicationKnockout mouse models for adhesion G protein-coupled receptors B3, brain-specific angiogenesis inhibitor-3 (ADGRB3/BAI3) gene study.Technical SummaryEmory University researchers have developed a knockout mouse model for the ADGRB3/BAI3 gene. Mice were generated by CRISP/cas9 technology on C57Bl6 background. These mice can be used to study...
Published: 10/28/2024   |   Inventor(s): Erwin Van Meir
Keywords(s): Animal Model, COVID19, Microbiology/Infectious Diseases, Musculoskeletal, Neuroscience/Pain, Oncology
Category(s): TechPub Algolia > Research Tools
3q29 Deletion Mice
Application Mouse models with the deletion of 3q29 for the study of neurological disorders such as schizophrenia, autism, and anxiety disorders. Technical Summary Copy Number Variants (CNV’s) are large genomic deletion or duplications. One of the CNV’s, the 3q29 deletion, confers more than 40 fold increase in risk of schizophrenia. Most...
Published: 9/26/2024   |   Inventor(s): Tamara Caspary, David Weinshenker, Stephen Theodore Warren
Keywords(s): Animal Model, Genetic Disorders, Neuroscience/Pain
Category(s): TechPub Algolia > Research Tools
Human Induced Pluripotent Stem Cells
ApplicationHuman induced pluripotent stem cells useful for human stem cell biology, Lesch-Nyhan disease or DYT1 dystonia.Technical SummaryLesch-Nyhan syndrome (juvenile gout) is a rare, inherited disorder caused by deficiency in hypoxanthine-guanine phosphoribosyltransferase (HGPRT). The disease causes overproduction of uric acid often leading to gout...
Published: 9/26/2024   |   Inventor(s): Hyder Jinnah
Keywords(s): Cell Line, Genetic Disorders, Neuroscience/Pain
Category(s): TechPub Algolia > Research Tools
Small Molecule Potentiators of NMDA Receptors for Treating Neurological Conditions
Application Multiple series of small molecules that selectivity potentiate NMDA receptors composed of specific subunits including GluN2B, GluN2C, GluN2B/GluN2C/GluN2D, and GluN2C/GluN2D. Key Benefits Small molecule potentiators enhance endogenous signals without exogenous activation. Subunit selectivity allows targeting of specific subtypes of...
Published: 7/30/2024   |   Inventor(s): Dennis Liotta, Ethel Garnier-Amblard, Gabriela Fernandez-Cuervo, Lanny Liebeskind, Pavan Kumar Reddy Gangireddy, Stephen Traynelis, Katie Strong, Rose Santangelo-Freel
Keywords(s): Neuroscience/Pain, Small Molecule
Category(s): TechPub Algolia > Drug Discovery, TechPub Algolia > Therapeutics
Progesterone to Treat Traumatic Brain Injury
Application The use of progesterone to treat patients with traumatic brain injury (TBI) via a tapered administration protocol. Key Benefits Early administration of progesterone reduces cerebral edema and neural loss, and improves behavioral recovery from traumatic brain injury (TBI) in pre-clinical animal models. Tapered progesterone withdrawal...
Published: 7/30/2024   |   Inventor(s): Donald Stein, Stuart Wayne Hoffman, Arthur Kellermann, David Wright, Douglas Lowery-North, Sarah Cutler
Keywords(s): Accident and Trauma, Neuroscience/Pain
Category(s): TechPub Algolia > Therapeutics
ReliefLink: a Suicide Prevention App
Application ReliefLink is a mobile companion app for suicide prevention. Key Benefits A companion app that includes mood tracking, reminders and safety plans. Location aware for finding the nearest hospitals and mental health treatment centers. Includes personalized coping mechanisms and assistance for finding therapists and support groups. Market...
Published: 7/30/2024   |   Inventor(s): Nadine Kaslow, Stephanie Johnson, Zhe (eric) Li, Lu Dong, R. Shawn Williams, Claire Lisco
Keywords(s): Mobile App, Neuroscience/Pain
Category(s): TechPub Algolia > Software
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