Search Results - mingyan+liu

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Tumor-pH–Triggered Doxorubicin Prodrug with On-Demand Shelf-Stable Precursor
This invention introduces a small-molecule doxorubicin prodrug that remains inert in blood and rapidly activates in the mildly acidic tumor microenvironment. Featuring a shelf-stable maleimide pre-prodrug that converts on demand to the ultra-acid-labile DMA form, it enables targeted chemotherapy with improved selectivity, scalable synthesis, and reduced...
Published: 11/12/2025   |   Inventor(s): Ming An, Lan Yao, Vladyslav Nazarenko
Keywords(s): Technologies
Category(s): Campus > Binghamton University
Multi-parametric Acoustic, Optical and Mechanical Imaging of Cervical Tissue Insufficiencies to Predict Preterm Birth
An enhanced image-guidance system that integrates ultrasound and photoacoustic into existing ablation systems to provide an enhanced image-guidance system for identification of cervical tissue changes during pregnancy and postpartum. Technology Summary Preterm delivery is a main cause of perinatal morbidity and mortality worldwide, which is associated...
Published: 10/1/2025   |   Inventor(s): Mohammad Mehrmohammadi, Sonia Hassan, Edgar Hernandez-Andrade, Yan Yan, Maryam Basij
Keywords(s): Driving Lifelong Health
Category(s): Technology Category > Women's Health, Technology Category > Medical Devices, Technology Category > Life Science, Technology Category > Imaging, Technology Category > Acoustics
Detection and Prediction of Mild Cognitive Impairment using Resting-State EEG
VALUE PROPOSITION Early discrimination and prediction of mild cognitive impairment (MCI) are crucial for the study of neurodegenerative mechanisms and interventions to promote cognitive resiliency. Existing work mainly focuses on the detection of MCI before Alzheimer’s onset; however, quantitative methods which enable prediction of progression...
Published: 4/22/2025   |   Inventor(s): Tongtong Li, Jinxian Deng, Boxin Sun, Bruno Giordani, Mingyan Liu, Voyko Kavcic
Keywords(s):  
Category(s): Medical
DNA Methylation Barriers
In normal differentiated cells, most of the genome is densely methylated, except CpG islands near promoters of actively transcribed genes. Maintaining this boundary between unmethylated promoter-associated and adjacent methylated regions is crucial as loss of segregation can lead to disease. Unfortunately, it is not clear where these boundaries are,...
Published: 2/13/2025   |   Inventor(s): Li Liu, Jingmin Shu
Keywords(s):  
Category(s): Applied Technologies, Genomic Assays/Reagents/Tools, Life Science (All LS Techs), Diagnostic Assays/Devices
An OCT method to improve scleral lens fitting
Summary The current technology allows for accurate and objective 3-dimensional (3D) mapping of the external limbus, which could ultimately improve the process of scleral lens fitting. Technology Overview Rigid scleral lenses are difficult to fit to patients because they must rest on the eye but vault over the cornea and the limbus, which is the transition...
Published: 9/4/2025   |   Inventor(s): David Huang, Yan Li, Clara Llorens Quintana
Keywords(s): Imaging, Imaging - Other, Software, Software - Diagnostic/Detection
Category(s): Imaging, Software
Self-Expanding Stent for Valve Replacement
Aortic stenosis and aortic regurgitation are the most common types of aortic valvular diseases. Such diseased aortic valves in the body are traditionally replaced with valve prosthesis by an open surgical implantation. Available for licensing and commercial development is intellectual property covering stents for use with valve prostheses. As illustrated...
Published: 10/28/2024   |   Inventor(s): Dumitru Mazilu, Ming Li, Keith Horvath
Keywords(s): AB3AXX, AB3CXX, AB3XXX, ABXXXX, Aortic Retinosis, AXXXXX, Patent Category - Mech/Elect/Soft, Self-expanding, STENT, Valve
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing
PMU-Embedded Analytics for Online Event Detection and Classification in Power Grids
The energy requirement of the world is increasing exponentially every year. With the power demand sites concentrated in the region with the highest population density, energy production sites must be located remotely. This isolation requires lengthy and complicated grids to be designed and manufactured to transmit power over long distances. Grid failures...
Published: 9/12/2025   |   Inventor(s): Payman Dehghanian, Shiyuan Wang, Li Li
Keywords(s):  
Category(s): Technology Classifications > Industrial or Consumer Tech > Energy Infrastructure and Environment
Control Plane System to Safely and Accurately Transfer Large Amounts of Data
Establishes Dedicated Bandwidths and Reserves Specific Channels to Efficiently Convey InformationThis device is designed to control access to a network which can be utilized by a variety of industries to safely and accurately transfer large amounts of data. High Bandwidth Systems are increasingly using control plane for managing the traffic on the network....
Published: 4/21/2023   |   Inventor(s): Sartaj Sahni, Sanjay Ranka, Yan Li, Eun-Sung Jung, Nara Kamath, Nageshwara Rao
Keywords(s): Backend Signaling, Bandwidth Scheduling, broadband technologies, data processing/data interchange, middleware, data protection, storage technology, cryptogr, Dedicated Bandwidth Channels, Future Resource Scheduling, GMPLS, In-Advance Circuit Provisioning, internet technologies/communication (wireless
Category(s): Technology Classifications > Engineering > Computer Science
Cell Cycle Nucleic Acids, Polypeptides and Uses Thereof - Wee1
This invention improves transformation frequency by changing levels of protein expression in the target cells, altering the cell cycle, specifically by modulating the activity of a gene known as RB3 which influences the cell's progression from G1 to S phase in the cell cycle. Overexpression of RB3 can be induced through existing methods of transient...
Published: 4/3/2023   |   Inventor(s): Paolo Sabelli, Yan Liu, Chunsheng Zhang, William Gordon-Kamm, Keith Lowe, Matthew Bailey, Xun Wang, Carolyn Gregory, George Hoerster, John Mcelver, Shane Abbitt, Benjamin Bowen, Brian Larkins, Brian Dilkes, Ricardo Dante, Yeujin Sun
Keywords(s):  
Category(s): Technology Classifications > Agriculture & Horticulture, Technology Classifications > Life Sciences, Technology Classifications > Agriculture & Horticulture > Crop Improvement, Technology Classifications > Life Sciences > Therapeutics
Distributed Feedback Fiber Laser Pumped by Multimode Diode Lasers
Researchers at the University of Arizona College of Optical Sciences and Canada's Carleton University recently succeeded in fabricating high reflectivity (>99%) Fiber Bragg Gratings (FBGs) into phosphate glass fibers using UV light and a phase mask technique. With this new manufacturing technique, fiber lasers can be created as single monolithic...
Published: 4/3/2023   |   Inventor(s): Nasser Peyghambarian, Axel Schülzgen, Li Li, Jacques Albert
Keywords(s):  
Category(s): Technology Classifications > Imaging & Optics, Technology Classifications > Imaging & Optics > Lasers & Other Sources
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