Search Results - medical+devices%2c+diagnostics+%26+biosensors

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Customizable genomic sequencing library Generation
PAGE TITLE Overview PAGE SUMMARY This innovation is a high-accuracy, low-cost, customizable genome sequencing method compatible with several long-read sequencing systems. It can be used to tailor target specific genomic sequencing -- increasing custom product offerings for sequencing service providers and kit manufacturers.. This technology...
Published: 2/19/2025   |   Inventor(s):  
Keywords(s):  
Category(s): Medical Devices, Diagnostics & Biosensors
Tools for Genomic Applications Powered by CRISPR/CAS9 Based DNA Labeling
PAGE TITLE Overview PAGE SUMMARY Executive Statement: Drexel has a portfolio of tools and platforms for genomics applications based on the CRISPR/CAS9 system. The portfolio has applications in clinical diagnostics, cell and gene therapy, and genomics research among others. We are seeking licensing partners to translate the platforms and diagnostic...
Published: 2/19/2025   |   Inventor(s):  
Keywords(s):  
Category(s): Medical Devices, Diagnostics & Biosensors
Biomimetic aggrecan injection for lower back pain treatment
PAGE TITLE Overview PAGE SUMMARY Proteoglycans (PGs) are a major building block and a hydrating agent in the extracellular matrix, which maintains structural organization of cells within tissues. PGs retain water and regulate flow of minerals and other nutrients, lubricate and provide mechanical support to the tissues. The combination of PGs and...
Published: 2/20/2025   |   Inventor(s): Michele Marcolongo, Caroline Schauer, Sumona Sarkar, Edward Vresilovic, Benjamin Jackson
Keywords(s): Aggrecan, Biomaterial, Biomimetic, Degenerative disc disease, Injectable, Lower back pain, Minimally Invasive, Spine
Category(s): Medical Devices, Diagnostics & Biosensors
Non-invasive quantitative monitor of depth of anesthesia and sedation
PAGE TITLE Overview PAGE SUMMARY Drexel researchers have developed a non-invasive device for quantitative, real-time monitoring of the depth of anesthesia both during general anesthesia in surgery and sedation in endoscopy and colonoscopy procedures. The device uses functional near-infrared (fNIR) spectroscopy to measure physiological parameters...
Published: 2/20/2025   |   Inventor(s): Kambiz Pourrezaei, Kurtulus Izzetoglu, Banu Onaral, Jay Horrow, Scott Bunce, Meltem Izzetoglu
Keywords(s): NIR - near infrared
Category(s): Medical Devices, Diagnostics & Biosensors
Low-cost manufacturing of highly sensitive label-free molecular detection substrates
PAGE TITLE Overview PAGE SUMMARY Label-free detection and characterization of molecules is an important tool for detecting a composition of a substance, be it a water, soil, chemical product or biological sample. Its main advantage is the ability to measure quantities of different molecules without knowing their identity in advance. Examples...
Published: 2/20/2025   |   Inventor(s): Som Tyagi, Kambiz Pourrezaei
Keywords(s):  
Category(s): Medical Devices, Diagnostics & Biosensors, Advanced Materials & Chemicals
Telomere assay for the detection of alternative lengthening of telomere (ALT) activity in cells
PAGE TITLE Overview PAGE SUMMARY Executive Statement: A unique tool for distinguishing cancer cells based on telomere maintenance mechanisms, providing potential biomarkers for cancer subtypes and therapeutic responses. Description: This technology provides detailed telomere profiling from individual chromosomes, capable of differentiating...
Published: 2/19/2025   |   Inventor(s): Ming Xiao
Keywords(s):  
Category(s): Medical Devices, Diagnostics & Biosensors
Quantification of On-off target gene editing by optical mapping
PAGE TITLE Overview PAGE SUMMARY Executive Statement: A revolutionary methodology for quantifying on-target and off-target gene editing activity using CRISPR-Cas9 and optical mapping. Description: This technology comprises a single-molecule optical mapping strategy using CRISPR-Cas9 to fluorescently label the modified genes. The method involves...
Published: 2/19/2025   |   Inventor(s): Ming Xiao, Yilin Wang, Lahari Uppuluri
Keywords(s):  
Category(s): Medical Devices, Diagnostics & Biosensors
Multicolor whole-genome mapping for genetic analysis
PAGE TITLE Overview PAGE SUMMARY Executive Statement: A novel method for precise genome mapping and sequencing using Cas9-mediated labeling within nanochannels. Description: This technology is a method for mapping a whole genome using a universal multi-color mapping strategy in nanochannels that combines a conventional sequence-motif labeling...
Published: 2/19/2025   |   Inventor(s): Ming Xiao, Lahari Uppuluri
Keywords(s):  
Category(s): Medical Devices, Diagnostics & Biosensors
Linked-read sequencing library preparation
PAGE TITLE Overview PAGE SUMMARY Executive Statement: Innovative methods for generating sequence-linked DNA fragments for high-quality, low-cost genome sequencing. Description: This technology describes a novel strategy to construct a long-read sequencing library such that adjacent fragments are linked with end-terminal duplications. The...
Published: 2/19/2025   |   Inventor(s): Ming Xiao, Lahari Uppuluri
Keywords(s):  
Category(s): Medical Devices, Diagnostics & Biosensors
Single molecule real-time long DNA mapping and sequencing
PAGE TITLE Overview PAGE SUMMARY Executive Statement: The invention offers an innovative way to immobilize and optically map/sequence oligonucleotides on a micropatterned substrate for efficient large-scale genomic assembly. Description: This technology presents a method for immobilizing and linearizing oligonucleotides on a micropatterned...
Published: 2/19/2025   |   Inventor(s): Ming Xiao, Dharma Varapula, Eric LaBouff, Moses (hongseok) Noh
Keywords(s):  
Category(s): Medical Devices, Diagnostics & Biosensors
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