Search Results - life+sciences+%3e+therapeutics

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Precision Gene Therapy for Diseases Driven by Endothelial Dysfunction

SHORT DESCRIPTION Dual promoter system constructs for tissue-specific and cell-type-specific gene expression, enabling precision gene therapy targeting endothelial dysfunction in specific organs. INVENTORS Youyang Zhao* Ann & Robert H Lurie Children's Hospital of Chicago * Principal Investigator NU...

Published: 4/27/2026 | Updated: 4/27/2026 | Inventor(s):

Keywords(s): Cardiology and Cardiovascular disease, CMD - Cardiometabolic disease, CPD - Cardiopulmonary disease, Gene therapy, Pulmonary disease, Regenerative medicine, Targeted therapy, Therapeutics, Vascular disease

Category(s): Life Sciences > Therapeutics

STING Agonist 8803 for Blood-Brain Barrier Opening in Glioblastoma Treatment

SHORT DESCRIPTION Chemical compound that opens the blood-brain barrier to enhance delivery of therapeutics for treating glioblastoma. INVENTORS Amy Heimberger* Northwestern University Feinberg School of Medicine, Department of Neurological Surgery * Principal Investigator NU 2025-212 IP STATUS US...

Published: 4/27/2026 | Updated: 4/27/2026 | Inventor(s):

Keywords(s): AD - Alzheimer’s Disease, Adjunct therapy, ALS - Amyotrophic Lateral Sclerosis, Animal Model, Autoimmune disease, Cancer/Oncology, CNS - Central Nervous System, Drug delivery, Immunology, Immunotherapy, MS - Multiple Sclerosis, Neurodegenerative disease, Neurologic disease, PD - Parkinson's Disease, Repurposed Drugs, Research tool, Small molecule, Targeted therapy, TBI - Traumatic brain injury

Category(s): Life Sciences > Therapeutics, Life Sciences > Biomarkers & Biomedical Research Tools

Selective PAD2 Inhibitors for Neuroprotection in Traumatic Brain Injury

SHORT DESCRIPTION Novel PAD2-selective inhibitor platform targeting neuroinflammation to support both acute neuroprotection and long-term functional recovery as a first-in-class treatment of traumatic brain injury. INVENTORS Hasan Alam* Northwestern University Feinberg School of Medicine, Department of Surgery (Trauma...

Published: 4/27/2026 | Updated: 4/27/2026 | Inventor(s):

Keywords(s): CNS - Central Nervous System, CVA - Cerebrovascular Accident, Neurodegenerative disease, Neuroinflammation, Neurologic disease, Neurology, Small molecule, Targeted therapy, TBI - Traumatic brain injury, Therapeutics

Category(s): Life Sciences > Therapeutics

Biomolecular Condensates as Protein Degradation Tools for Intracellular Targets

SHORT DESCRIPTION A targeted-protein degradation platform for intracellular targets, addressing resistant oncogenic and neurodegenerative targets. INVENTORS Shana Kelley* Weinberg College of Arts & Sciences, Department of Chemistry Yi Li * Principal Investigator NU 2025-050 IP STATUS PCT...

Published: 4/27/2026 | Updated: 4/27/2026 | Inventor(s):

Keywords(s): AD - Alzheimer’s Disease, Biologic, Biomolecular condensates, Cancer/Oncology, Drug delivery, Nanoparticle, Neurodegenerative disease, Neurologic disease, Neurology, PD - Parkinson's Disease, Platform technology, Targeted protein degradation, Targeted therapy, Therapeutics

Category(s): Life Sciences > Therapeutics, Life Sciences > Biomarkers & Biomedical Research Tools

Methods to Treat Neurodegenerative Disorders by Reducing Nuclear Aggregates and Modulating Adenosine‑to‑Inosine RNA Editing

SHORT DESCRIPTION Novel disease‑modifying approach that dissolves toxic nuclear RNA–protein aggregates and restores synaptic function in neurodegenerative diseases by inhibiting adenosine‑to‑inosine (A‑to‑I) RNA editing and modulating ADAR enzymes. INVENTORS Joseph Mazzulli* Northwestern University Feinberg School...

Published: 4/27/2026 | Updated: 4/27/2026 | Inventor(s):

Keywords(s): Lewy bodies, Neurodegenerative disease, Neurology, PD - Parkinson's Disease, RNA - Ribonucleic Acid, Small molecule, Targeted therapy, Therapeutics

Category(s): Life Sciences > Therapeutics

Mitigating aberrant Cdk5 Activation in SMA – A Novel Therapeutic Strategy Targeting Mitochondrial Function

SHORT DESCRIPTION A targeted strategy that mitigates aberrant Cdk5 activity to restore mitochondrial function and reduce motor neuron degeneration in SMA models. INVENTORS Yongchao Ma* Northwestern University Feinberg School of Medicine, Department of Pediatrics * Principal Investigator NU Tech...

Published: 4/27/2026 | Updated: 4/27/2026 | Inventor(s):

Keywords(s): Adjunct therapy, Neurodegenerative disease, Neurologic disease, Neurology, Rare diseases, SMA - Spinal muscular atrophy, Targeted therapy, Therapeutics

Category(s): Life Sciences > Therapeutics

Use of Neuronal NOS Inhibitors for Alzheimer's Therapeutic Intervention

PROPOSED TITLE (cut & paste into Alternate Title): Use of Neuronal NOS Inhibitors for Alzheimer's Therapeutic Intervention NU 2023-007 SHORT DESCRIPTION A small molecule based approach that mitigates Alzheimer's neurodegeneration by inhibiting neuronal nitric oxide synthase to prevent tau phosphorylation and reduce Aβ oligomer formation. INVENTORS Richard...

Published: 4/27/2026 | Updated: 4/27/2026 | Inventor(s):

Keywords(s): AD - Alzheimer’s Disease, Covalent inhibitor, Kinase Inhibitor, Neurodegenerative disease, Neurology, nNOS, Small molecule, Targeted therapy, Therapeutics

Category(s): Life Sciences > Therapeutics

Inhibitors of TRIP8b for Novel Mood Disorder Therapeutics

SHORT DESCRIPTION For mood disorder treatment, these novel inhibitors disrupt TRIP8b-HCN binding to offer an alternative antidepressant mechanism. INVENTORS Gary Schiltz* Weinberg College of Arts and Sciences, Department of Chemistry Dane Chetkovich Ye Han Iredia Iyamu Kyle Lyman * Principal...

Published: 4/27/2026 | Updated: 4/27/2026 | Inventor(s):

Keywords(s): Antidepressant, Depression, Mood disorder, Neurologic disease, Neurology, Psychiatric disease, Targeted therapy, Therapeutics

Category(s): Life Sciences > Therapeutics

N-desmethyl Tamoxifen and Derivatives for Effective Pain Relief

SHORT DESCRIPTION A novel state-dependent tamoxifen‑derived small molecule anti-pain medication that selectively blocks peripheral voltage‑gated sodium channels to deliver potent, non‑opioid analgesia in chronic and inflammatory pain. INVENTORS Paul DeCaen* Northwestern University Feinberg School of Medicine, Department...

Published: 4/27/2026 | Updated: 4/27/2026 | Inventor(s):

Keywords(s): Chronic pain, Neurology, Non-opioid, Pain management, Small molecule, Therapeutics

Category(s): Life Sciences > Therapeutics, Life Sciences > Biomarkers & Biomedical Research Tools

Drug Repurposing for Age-Impaired Vascular Repair in COVID-19, Sepsis, and ARDS

SHORT DESCRIPTION Methods and compositions for treating COVID-19, sepsis, acute respiratory distress syndrome (ARDS), and cardiovascular diseases in elderly patients by either inhibiting vascular endothelial injury/inflammation or promoting FOXM1-dependent endothelial regeneration and vascular repair. INVENTORS Youyang Zhao Northwestern...

Published: 4/27/2026 | Updated: 4/22/2026 | Inventor(s):

Keywords(s): ARDS - Acute Respiratory Distress Syndrome, COVID-19, Immunology, Infectious disease, Inflammation, Pulmonary disease, Therapeutics, Vascular disease, Vascular repair

Category(s): Life Sciences > Therapeutics

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