Search Results - life+sciences+%3e+therapeutics

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A platform for mapping reactive cysteines within the immunopeptidome
NU 2024-044 INVENTORS Xiaoyu Zhang* Chenlu Zhang Chen Zhou SHORT DESCRIPTION This invention provides novel chemical probes for mapping reactive cysteine residues within the major histocompatibility complex class I (MHC-I) immunopeptidome. BACKGROUND The immune system's recognition of infected or malignant cells hinges on the presentation...
Published: 10/31/2025   |   Inventor(s):  
Keywords(s):  
Category(s): Life Sciences > Therapeutics
Spherical Nucleic Acids with Sheddable PEG Layers
Spherical Nucleic Acids with Sheddable PEG Layers for Enhanced Tumor Targeting NU 2017-169 INVENTORS Chad Mirkin* (Northwestern University, Weinberg College of Arts and Sciences, Department of Chemistry, Director of the International Institute for Nanotechnology (IIN)) Brian Meckes Wuliang Zhang SHORT DESCRIPTION For oncology applications,...
Published: 10/30/2025   |   Inventor(s):  
Keywords(s): Biologic, Biomarker, Biomedical, Cancer/Oncology, Chemicals, Diagnostics, Drug delivery, Nanoparticle, Nanotechnology, Personalized medicine, Therapeutics
Category(s): Life Sciences > Therapeutics, Life Sciences > Healthcare Devices, Tools & IT, Life Sciences > Biomarkers & Biomedical Research Tools
Cord Blood Protein Biomarkers to Identify Early-Onset Neonatal Sepsis
LNU 2024-090 INVENTORS Leena Mithal* SHORT DESCRIPTION A diagnostic assay developed using proteomic biomarkers from umbilical cord blood to rapidly risk stratify newborns for early-onset neonatal sepsis, enabling targeted antibiotic therapy and improved outcomes. BACKGROUND Current approaches to diagnose early-onset sepsis rely on postnatal...
Published: 10/30/2025   |   Inventor(s):  
Keywords(s):  
Category(s): Life Sciences > Therapeutics
TauSeeK: Disease Specific Tau Protein Fibrils & Seeding Proteins
NU 2024-154 INVENTORS Songi Han* Austin Dubose Michael Vigers Andrew Longhini Vishnu Vijayan Kenneth Kosik Samuel Lobo Peter C. Ryffel Lokeswara Rao Potnuru Karen Tsay Chung-Ta Han SHORT DESCRIPTION Compositions, kits, and methods for generating synthetic miniature tau peptides and fibrils, and synthetic full-length pathogenic tau...
Published: 10/30/2025   |   Inventor(s):  
Keywords(s):  
Category(s): Life Sciences > Therapeutics
Covalent ATG4B Inhibitors for Treatment of Cancer
NU2025-186 INVENTORS Karl Scheidt* Claire Trudeau Shiyuan Cheng SHORT DESCRIPTION The invention introduces a novel class of peptidyl covalent reversible ketoamide inhibitors designed to target the cysteine protease ATG4B. BACKGROUND Glioblastoma (GBM) is an aggressive and highly malignant tumor of the central nervous system, characterized...
Published: 10/28/2025   |   Inventor(s):  
Keywords(s):  
Category(s): Life Sciences > Therapeutics
Fungal Natural Product Discovery Using FAC-MS Technology
NU 2016-068 INVENTORS Neil Kelleher* Kenneth Clevenger Paul Thomas SHORT DESCRIPTION This platform uses fungal artificial chromosomes and ultra‐high mass accuracy LC-MS to profile secondary metabolites. It offers a rapid, scalable approach for natural product discovery in drug and agricultural research. BACKGROUND Current natural product...
Published: 10/21/2025   |   Inventor(s):  
Keywords(s): Therapeutics
Category(s): Life Sciences > Therapeutics
Methods for assembling peptides into peptide amphiphile nanofibers
TITLE: Peptide Nanofiber Assembly for Enhanced Therapeutic Delivery NU 2020-081 SHORT DESCRIPTION This technology uses self-assembling peptide amphiphile nanofibers to protect and deliver therapeutic peptides. It reduces degradation and improves delivery efficiency for advanced treatment applications. BACKGROUND Peptide therapeutics offer promise...
Published: 10/21/2025   |   Inventor(s):  
Keywords(s): Drug delivery, Nanomaterials
Category(s): Life Sciences > Therapeutics
Covalent MEK4 Inhibitors for Targeted Cancer Therapy
NU 2025-154 INVENTORS Karl Scheidt* Gina Connors SHORT DESCRIPTION This technology introduces novel covalent inhibitors of MEK4, built upon previously-developed reversible inhibitors (see NU2019-059 and NU2021-217). A covalent inhibition strategy offers enhanced potency, selectivity, and prolonged duration of action compared to reversible...
Published: 10/20/2025   |   Inventor(s):  
Keywords(s): Cancer/Oncology, Covalent Inhibition, Kinase Inhibitor, MEK4, MEK7
Category(s): Life Sciences > Therapeutics
Methods for Treatment of Sepsis and Acute Respiratory Distress Syndrome
LU2025-192 INVENTORS Youyang Zhao Colin Evans SHORT DESCRIPTION This invention identifies endothelial ALOX15 and its lipid product, 1-Palmitoyl-2-Oleoyl-3-Arachidonoyl-rac-glycerol (POLAR), as key targets for treating sepsis and acute respiratory distress syndrome (ARDS). BACKGROUND Sepsis-induced acute lung injury (ALI) and acute...
Published: 10/17/2025   |   Inventor(s):  
Keywords(s):  
Category(s): Life Sciences > Therapeutics
Clinical Bacterial Isolate Engineered as Prostate Cancer Immunotherapy
NU 2015-087 INVENTORS Praveen Thumbikat* Anthony Schaeffer Jonathan Anker Sarki Abdulkadir SHORT DESCRIPTION This technology uses a genetically modified CP1 E. coli as an immunotherapeutic agent for prostate cancer. It offers a non-invasive treatment option designed to stimulate an immune response in both early stage and advanced disease. BACKGROUND Existing...
Published: 10/10/2025   |   Inventor(s):  
Keywords(s): Cancer/Oncology, Therapeutics
Category(s): Life Sciences > Therapeutics
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