Search Results - life+sciences+%3e+therapeutics

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Small Molecule Inhibitors of Pleckstrin-2 for Treating Myeloproliferative Neoplasms
SHORT DESCRIPTION Small molecule inhibitors of Pleckstrin-2 (Plek2) for treating cell proliferative diseases and disorders, particularly myeloproliferative neoplasms (MPNs). NU Tech IDs: NU 2018-169, NU 2021-005 PRINCIPAL INVESTIGATOR Peng Ji Northwestern University Feinberg School of Medicine, Department of Pathology IP...
Published: 4/16/2026   |   Updated: 4/16/2026   |   Inventor(s):  
Keywords(s): Breast cancer, Cancer/Oncology, Colon cancer, Leukemia, Lung cancer, Pancreatic cancer, Small molecule, Therapeutics
Category(s): Life Sciences > Therapeutics
Nano-therapeutics Targeting Cholesterol Efflux Transporter in Macrophages for Cancer Immunotherapy
NU 2025-160 INVENTORS Jason Miska* Feinberg School of Medicine, Department of Neurological Surgery Peng Zhang* Feinberg School of Medicine, Department of Neurological Surgery SHORT DESCRIPTION Novel nanoparticle technology that modulates macrophage cholesterol metabolism to boost anti-tumor immunity in GBM. BACKGROUND Glioblastoma...
Published: 4/16/2026   |   Updated: 4/14/2026   |   Inventor(s):  
Keywords(s): Adjunct therapy, Brain cancer, Cancer/Oncology, CNS - Central Nervous System, Drug delivery, Immunotherapy, Nanoparticle, Neurologic disease, Therapeutics
Category(s): Life Sciences > Therapeutics
SEC61 Complex as a Novel Therapeutic Target to Enhance Immunotherapy Response in Glioblastoma
NU 2023-011 INVENTORS Irina Balyasnikova* Northwestern University Feinberg School of Medicine, Department of Neurological Surgery Joseph Duffy SHORT DESCRIPTION A targeted therapeutic approach that inhibits the SEC61 complex to enhance responses to immunotherapy in glioblastoma. BACKGROUND Glioblastoma (GBM) is the most aggressive primary...
Published: 4/14/2026   |   Updated: 4/14/2026   |   Inventor(s):  
Keywords(s): Brain cancer, Cancer/Oncology, Immunotherapy, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics
Anti-TYRP1 Bi-specific T cell Engager for Treatment of TYRP1-expressing melanoma
NU 2022-123 INVENTORS Irina Balyasnikova (Feinberg School of Medicine, Department of Neurological Surgery)* Isabelle Le Poole (Feinberg School of Medicine, Department of Dermatology)* SHORT DESCRIPTION A bispecific T cell engager that targets CD3+ T cells and TYRP1-expressing melanoma cells. BACKGROUND Melanoma is the deadliest form of skin...
Published: 4/14/2026   |   Updated: 4/14/2026   |   Inventor(s):  
Keywords(s): Biologic, Cancer/Oncology, Immunotherapy, Melanoma, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics
JNK Inhibitors Targeting Bergmann Glia Inflammation to Mitigate Spinocerebellar Ataxia and Other Neurodegenerative Disorders
SHORT DESCRIPTION Novel therapeutic strategy targeting Bergmann glia inflammation using JNK inhibition for treatment of spinocerebellar ataxia type 1 (SCA1) and other neurodegenerative disorders. INVENTORS Puneet Opal* Northwestern University Feinberg School of Medicine, Professor of Neurology Chandrakanth...
Published: 4/16/2026   |   Updated: 4/14/2026   |   Inventor(s):  
Keywords(s): Bergmann glia inflammation, Neurodegenerative disease, Neuroinflammation, Neurologic disease, Neurology, Rare diseases, SCA - Spinocerebellar ataxia, Small molecule, Therapeutics
Category(s): Life Sciences > Therapeutics
Synthetic Receptors for IL-23
NU 2024-093 SHORT DESCRIPTION Synthetic IL-23 receptors for cell engineering to enable real-time sensing and drive precise autoimmune and cancer immunotherapy interventions. INVENTORS Joshua Leonard* McCormick School of Engineering, Department of Chemical and Biological Engineering Aaron Morris William...
Published: 4/14/2026   |   Updated: 4/14/2026   |   Inventor(s):  
Keywords(s): Autoimmune disease, Cell engineering, Cell therapy, Diagnostics, IBD - Inflammatory bowel disease, Immunology, Immunotherapy, Inflammation, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics, Life Sciences > Biomarkers & Biomedical Research Tools
Responsive Probiotic Therapy for Local Detection and Treatment of IBD Flares
NU 2024-047 SHORT DESCRIPTION An engineered probiotic that senses intestinal inflammation via calprotectin and locally releases therapeutic antibodies in the gastrointestinal tract only during inflammatory flares. INVENTORS Arthur Prindle* McCormick School of Engineering, Department of Chemical and Biological Engineering Jonathan...
Published: 4/14/2026   |   Updated: 4/14/2026   |   Inventor(s):  
Keywords(s): Autoimmune disease, Biologic, Cell therapy, Diagnostics, Gastrointestinal and Hepatic disease, IBD - Inflammatory bowel disease, Immunology, Immunotherapy, Inflammation, Synthetic biology, Therapeutics
Category(s): Life Sciences > Therapeutics
Bi-specific Lipid Nanoparticles for Boosting Antitumor Immunity in Glioblastoma
NU 2022-151 SHORT DESCRIPTION A bispecific lipid nanoparticle that bridges tumor-associated myeloid cells (TAMCs) and glioma cells by dual checkpoint blockade and simultaneously reprograms TAMCs into antitumor effectors via targeted delivery of a STING agonist. INVENTORS Maciej Lesniak* Northwestern University Feinberg...
Published: 4/14/2026   |   Updated: 4/14/2026   |   Inventor(s):  
Keywords(s): Brain cancer, Cancer/Oncology, Drug delivery, Immunotherapy, Nanoparticle, Nanotechnology, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics
Recombinant Annexin Therapy for Muscle, Cardiac, and Neuronal Cell Membrane Repair
NU 2022-008 SHORT DESCRIPTION An annexin-based biological therapeutic that enhances the body's natural cell membrane repair process to reduce skeletal muscle, cardiac, and neuronal cell death and preserve tissue function. INVENTORS INVENTORS Elizabeth McNally* Feinberg School of Medicine, Department of Medicine (Cardiology...
Published: 4/14/2026   |   Updated: 4/14/2026   |   Inventor(s):  
Keywords(s): Biologic, Cardiomyopathy, DMD - Duchenne muscular dystrophy, Inflammation, Membrane injury and repair, Neurodegenerative disease, Rare diseases, SCI - Spinal cord injury, TBI - Traumatic brain injury, Therapeutics
Category(s): Life Sciences > Therapeutics
Neuronal nitric oxide synthase (nNOS) inhibitors for targeted therapy of melanoma and neurodegenerative disorders
NU 2025-113 (NU 2016-137, NU 2018-176, NU 2019-179, NU 2023-007, NU 2024-250, NU 2025-038) INVENTORS Richard Silverman (Weinberg College of Arts and Sciences, Department of Chemistry) SHORT DESCRIPTION Novel highly selective neuronal nitric oxide synthase (nNOS) inhibitors for targeted therapy of melanoma and other cancers with high expression...
Published: 4/14/2026   |   Updated: 4/1/2026   |   Inventor(s):  
Keywords(s): ALS - Amyotrophic Lateral Sclerosis, AUTM26C1, BIAUTM1, Cancer/Oncology, Cardiology and Cardiovascular disease, Immunodeficiency, Immunology, Immunotherapy, Melanoma, Neurodegenerative disease, Neuroinflammation, nNOS, Small molecule, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics
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