Search Results - life+sciences+%3e+therapeutics

179 Results Sort By:
A transient closed-loop system
PROPOSED TITLE (cut & paste into Alternate Title): Transient Closed-Loop System for Autonomous Cardiac Electrotherapy NU NUMBER NU 2021-255 INVENTORS Igor Efimov* John Rogers* Hyoyoung Jeong Rose Yin Yeonsik Choi SHORT DESCRIPTION For cardiac care providers, this novel system integrates wireless, body-integrated devices to provide autonomous,...
Published: 12/9/2025   |   Inventor(s):  
Keywords(s):  
Category(s): Life Sciences > Healthcare Devices, Tools & IT, Life Sciences > Therapeutics
The use of complex or fusion protein of soluble MIC (Smic) and antibody to treat MIC-negative cancer
NU 2019-146 INVENTORS Jennifer Wu* SHORT DESCRIPTION A fusion protein complex comprising soluble MIC and a non-blocking sMIC-neutralizing antibody that effectively activates CD8 T cells for the treatment of MIC-negative cancer. BACKGROUND Effective T cell co-stimulation is critical for durable tumor control, yet many current immunotherapies...
Published: 12/9/2025   |   Inventor(s):  
Keywords(s): Antibody, Cancer/Oncology, Research tool
Category(s): Life Sciences > Therapeutics
Engineered B-cell Therapy for Cancer Treatment
NU 2022-218 INVENTORS Catalina Lee Chang* Maciej Lesniak* SHORT DESCRIPTION Engineered B cells with reduced expression of key immune checkpoint proteins designed to boost cancer immunotherapy efficacy. BACKGROUND Immunotherapy has transformed cancer treatment; however, its application to brain tumors remains limited by the immunosuppressive...
Published: 12/3/2025   |   Inventor(s):  
Keywords(s): Cancer/Oncology
Category(s): Life Sciences > Therapeutics
The Use of Annexins in Preventing and Treating Muscle Membrane Injury
NU 2018-119 INVENTORS Elizabeth McNally* Alexis Demonbreun SHORT DESCRIPTION An annexin-based biological therapeutic that enhances the body's natural cell membrane repair process to reduce muscle cell death and preserve tissue function. BACKGROUND Cell membrane integrity is critical for survival, especially in tissues under constant mechanical...
Published: 12/9/2025   |   Inventor(s):  
Keywords(s): Neurodegenerative disease, Therapeutics
Category(s): Life Sciences > Therapeutics
New Therapeutic Approach for the Treatment of Acute Myeloid Leukemia
NU 2017-214 Inventors Ali Shilatifard* Zibo Zhao Short Description A new therapeutic approach for the treatment of acute myeloid leukemia using casein kinase inhibitors. Background Leukemia is a group of cancers that affects the bone marrow and results in the overproduction of dysfunctional white blood cells (WBCs). The mixed lineage leukemia...
Published: 11/18/2025   |   Inventor(s):  
Keywords(s): Cancer/Oncology, Therapeutics
Category(s): Life Sciences > Therapeutics
Arylazanylpyrazolone Inhibition of Mutant SOD1 Mediated Cytotoxicity and Application to the Treatment of ALS
✅ Feedback form for Tech ID 2012-178 PROPOSED TITLE: Arylazanylpyrazolone Inhibition of Mutant SOD1 Cytotoxicity for ALS Treatment NU 2012-178 INVENTORS Richard Silverman* Yinan Zhang SHORT DESCRIPTION Compounds based on arylazanylpyrazolone derivatives inhibit mutant SOD1-mediated cytotoxicity, offering a promising approach for ALS treatment. BACKGROUND Amyotrophic...
Published: 11/18/2025   |   Inventor(s):  
Keywords(s): Therapeutics
Category(s): Life Sciences > Therapeutics
2-(Pyridin-3-yl)quinazoline compounds as glucocerebrosidase modulators
✅ Feedback form for Tech ID 2015-064 PROPOSED TITLE: 2-(Pyridin-3-yl) quinazoline Compounds as Glucocerebrosidase Modulators NU 2015-064 INVENTORS Richard Silverman* Dimitri Krainc Jianbin Zheng SHORT DESCRIPTION Novel substituted quinazoline compounds that modulate glucocerebrosidase activity, offering a promising therapeutic approach for...
Published: 11/18/2025   |   Inventor(s):  
Keywords(s): Neurodegenerative disease, Neurologic disease, PD - Parkinson's Disease, Research tool, Therapeutics
Category(s): Life Sciences > Therapeutics
Development of Therapeutics for Amyotrophic Lateral Sclerosis (ALS)
NU 2008-163 and NU2009-098 Inventors Richard B. Silverman* Richard Morimoto P. Hande Ozdinler Short Description Three series of New Chemical Entities (NCEs) that exhibit efficacy in an ALS animal model Background ALS causes muscle weakness and atrophy due to the degeneration of the upper and lower motor neurons. This disease is both genetic...
Published: 11/18/2025   |   Inventor(s):  
Keywords(s): Neurodegenerative disease, Neurologic disease, Therapeutics
Category(s): Life Sciences > Therapeutics
Pyrimidine-2,4,6-Trione Derivatives Preparation and Their Use for the Treatment of Amyotrophic Lateral Sclerosis (ALS) ALS Therapy
NU 2009-072 INVENTORS Richard Morimoto* Richard Silverman* Gavin Guoyao Xia SHORT DESCRIPTION This invention discloses novel pyrimidine-2,4,6-trione derivatives (PYT compounds) that prevent abnormal protein aggregation associated with ALS, offering a promising new therapeutic approach for neurodegenerative diseases. BACKGROUND Amyotrophic...
Published: 11/18/2025   |   Inventor(s):  
Keywords(s): ALS - Amyotrophic Lateral Sclerosis, Neurodegenerative disease, Therapeutics
Category(s): Life Sciences > Therapeutics
Compounds and methods for FBXW7-R465C-mediated protein degradation
NU 2024-224 INVENTORS Xiaoyu Zhang* Ananya Basu SHORT DESCRIPTION This invention describes novel heterobifunctional compounds that exploit a somatic mutant of the FBXW7 E3 ligase for targeted protein degradation. BACKGROUND Targeted protein degradation (TPD) is a powerful therapeutic strategy that harnesses the cell's natural machinery...
Published: 11/18/2025   |   Inventor(s):  
Keywords(s):  
Category(s): Life Sciences > Therapeutics
1 2 3 4 5 6 7 8 9 10 ...