Search Results - life+sciences+%3e+therapeutics

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SAFE, AUTOMATED, AND HIGH YIELDING METHOD FOR SYNTHESIZING DEOXYOLIGONUCLEICGUANIDINES (DNG) STRANDS

yle> NU2019-109 Short Description Spherical nucleic acids (SNAs) incorporating deoxynucleic guanidine (DNG)-modified oligonucleotides enable improved cellular uptake and intracellular delivery by introducing positively charged backbone modifications. Background Oligonucleotide therapeutics, including antisense and RNA interference (RNAi) approaches,...

Published: 5/18/2026 | Updated: 5/18/2026 | Inventor(s):

Keywords(s): Drug delivery, Nucleic Acids, Platform technology, Research tool

Category(s): Life Sciences > Therapeutics

Piperacillin for Targeted Lyme Disease Treatment

Piperacillin for Targeted Lyme Disease Treatment SHORT DESCRIPTION For infectious disease clinicians, this piperacillin-based therapeutic approach targets Lyme disease by inhibiting bacterial cell wall synthesis to reduce disease progression. INVENTORS INVENTORS Brandon Jutras* * Principal Investigator NU Tech ID:...

Published: 5/18/2026 | Updated: 5/18/2026 | Inventor(s):

Keywords(s):

Category(s): Life Sciences > Therapeutics

Northwestern Startup: Akava Therapeutics

Founded: 2019 Northwestern Inventor: Richard Silverman Weinberg College of Arts and Sciences Department of Chemistry and Department of Molecular Biosciences Feinberg School of Medicine Department of Pharmacology AKAVA Therapeutics is developing first-in-class small molecule therapeutics that inhibit enzymes, inhibit cancer, and inhibit protein...

Published: 5/13/2026 | Updated: 5/13/2026 | Inventor(s):

Keywords(s): ALS - Amyotrophic Lateral Sclerosis, Neurodegenerative disease, Neurology, Therapeutics

Category(s): Life Sciences > Therapeutics

Epigenetic Gene Editing in Cardiomyopathy to Improve Heart Function

SHORT DESCRIPTION A precision cardiac gene‑regulation platform that deletes a MYH7 enhancer to shift ventricular myosin isoform balance toward faster α‑MHC and activates upstream MYH6 enhancers to increase MYH6 expression and improve contractility, creating a dual toolkit for disease‑modifying therapy in cardiomyopathy and heart failure. INVENTORS Elizabeth...

Published: 5/15/2026 | Updated: 5/12/2026 | Inventor(s):

Keywords(s): Cardiology and Cardiovascular disease, Cardiomyopathy, Gene therapy, Regenerative medicine, Therapeutics

Category(s): Life Sciences > Therapeutics

Targeted Nanoparticle-Mediated HIF Stabilization in Myeloid Cells for Enhanced Transplant Tolerance

SHORT DESCRIPTION A PEG-PPS nanoparticle technology for targeted delivery of roxadustat to myeloid cells to promote transplantation tolerance. INVENTORS Edward Thorp* Northwestern University Feinberg School of Medicine, Department of Pathology Evan Scott* McCormick School of Engineering, Department...

Published: 5/7/2026 | Updated: 5/7/2026 | Inventor(s):

Keywords(s): Drug delivery, Immunotherapy, Nanoparticle, Therapeutics, Tolerance induction, Transplantation

Category(s): Life Sciences > Therapeutics

Targeting Autoimmunity-Associated T cells via AHR Pathway Control

SHORT DESCRIPTION Use of AHR agonists to inhibit pathogenic Tfh/Tph cell differentiation, potentially reducing disease activity. INVENTORS Jaehyuk Choi* Northwestern University Feinberg School of Medicine, Department of Dermatology **(Now at UT Southwestern)** Deepak Rao Brigham and Women's...

Published: 5/7/2026 | Updated: 5/7/2026 | Inventor(s):

Keywords(s): Autoimmune disease, Immunology, Immunotherapy, Inflammation, RA - Rheumatoid arthritis, SLE - Systemic lupus erythematosus, Small molecule, Therapeutics

Category(s): Life Sciences > Therapeutics

Antisense Oligonucleotides to Prevent Genetic Mis-Splicing for ALS/FTD Therapeutics

SHORT DESCRIPTION Antisense oligonucleotides (ASOs) that correct TDP‑43–dependent mis‑splicing of KCNQ2 thereby reducing neuronal hyperexcitability in ALS/FTD and related TDP‑43 proteinopathies. INVENTORS Evangelos Kiskinis* Northwestern University Feinberg School of Medicine, Department of Neurology Jonathan...

Published: 5/12/2026 | Updated: 5/7/2026 | Inventor(s):

Keywords(s): ALS - Amyotrophic Lateral Sclerosis, FTD - Frontotemporal Dementia, Neurodegenerative disease, Neurologic disease, Neurology, Nucleic Acids, Rare diseases, Targeted therapy, Therapeutics

Category(s): Life Sciences > Therapeutics

Incomplete Autophagy Induction for the Treatment of Cancer

SHORT DESCRIPTION This incomplete autophagy inducer triggers caspase-mediated apoptosis in cancer cells by inducing incomplete autophagy, leading to tumor reduction and improved survival. INVENTORS INVENTORS Maciej Lesniak* Northwestern University Feinberg School of Medicine, Department of Neurological Surgery Jawad...

Published: 5/13/2026 | Updated: 5/7/2026 | Inventor(s):

Keywords(s): Autophagy, Brain cancer, Breast cancer, Cancer/Oncology, Lung cancer, Melanoma, Repurposed Drugs, Small molecule, Therapeutics

Category(s): Life Sciences > Therapeutics

Once-Weekly Glucocorticoid Steroid Dosing for Enhanced Muscle Function and Metabolic Health

SHORT DESCRIPTION A glucocorticoid regimen that preserves the benefits of steroids on muscle mass and function while mitigating many of the metabolic and growth‑related toxicities seen with daily dosing in various inflammatory, autoimmune, respiratory, and neuromuscular disease settings. INVENTORS Elizabeth McNally*, MD, PhD Northwestern...

Published: 5/11/2026 | Updated: 5/7/2026 | Inventor(s):

Keywords(s): Aging, DMD - Duchenne muscular dystrophy, Immunology, Inflammation, Metabolic disorders, Muscle metabolism, Rare diseases, Small molecule, Therapeutics

Category(s): Life Sciences > Therapeutics

Northwestern Startup: Acumen Pharmaceuticals, Inc.

Founded: 1996 Northwestern Inventor: William Klein Weinberg College of Arts and Sciences Department of Neurobiology and Physiology Grant Krafft Feinberg School of Medicine Department of Molecular Pharmacology and Biological Chemistry Acumen Pharmaceuticals develops therapeutics for Alzheimer's Disease (AD) based upon the discovery and characterization...

Published: 5/7/2026 | Updated: 5/7/2026 | Inventor(s):

Keywords(s): Antibody, Neurodegenerative disease, Neurologic disease, Therapeutics

Category(s): Life Sciences > Therapeutics, Life Sciences > Healthcare Devices, Tools & IT

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