Search Results - life+sciences+%3e+therapeutics

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Aminopyrimidine-based Kinase Inhibitors for Treatment of Cancer
NU 2015-098 Inventors Leonidas C. Platanias* Gary E. Schiltz Rama K. Mishra Short Description A small molecule to treat glioblastoma multiforme by blocking the Mnk pathway. Background Glioblastoma multiforme (GBM) is an aggressive brain cancer associated with a low survival rate, high recurrence, and limited therapeutic options. Most diagnosed...
Published: 3/5/2026   |   Inventor(s):  
Keywords(s): AD - Alzheimer’s Disease, Cancer/Oncology, Small molecule, Therapeutics
Category(s): Life Sciences > Therapeutics
Covalent PRC2 Inhibitors for Advanced Cancer Therapeutics
SHORT DESCRIPTION Covalent inhibitors and proteolysis-targeting chimera (PROTAC) degraders targeting components of the PRC2 complex (EZH and EED) to block both enzymatic and non-enzymatic functions, offering robust anti-tumor efficacy. INVENTORS Gary Schiltz (Weinberg College of Arts and Sciences, Department of Chemistry)* Jindan...
Published: 3/5/2026   |   Inventor(s):  
Keywords(s): AUTM26C1, BIAUTM1, Bladder cancer, Breast cancer, Cancer/Oncology, Covalent inhibitor, Lymphoma, Melanoma, PreSeed/Seed, Prostate cancer, PROTAC, Small molecule, Targeted protein degradation, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics
Inhibition of BACH1 for pulmonary arterial hypertension therapy
LU 2024-222 INVENTORS Youyang Zhao* SHORT DESCRIPTION This invention identifies a protein called BACH1 as a key driver of pulmonary arterial hypertension (PAH). By targeting and inhibiting BACH1, particularly in the pulmonary endothelium, this technology provides methods for preventing or reversing the abnormal thickening of pulmonary vasculature,...
Published: 3/5/2026   |   Inventor(s):  
Keywords(s): Cardio-Pulmonary, Pulmonary disease, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics
Antibodies for treatment of coronavirus disease
NU 2023-247 INVENTORS Huiping Liu* Deyu Fang* Hannah Mubarak Andrew Hoffmann Nurmaa Dashzeveg Lamiaa El-Shennawy Juncheng Wei Wuwei Tan Yang Shen SHORT DESCRIPTION Computationally redesigned antibodies targeting SARS-CoV-2 for treating COVID-19. BACKGROUND The continuous evolution of SARS-CoV-2 has allowed the virus to escape most therapeutic...
Published: 2/26/2026   |   Inventor(s):  
Keywords(s): Antibody, Artificial Intelligence & Machine Learning, Biologic, Infectious disease, Research tool, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics
Engineered T-cell receptor platforms for targeted detection and treatment of cytomegalovirus-infected cells
This technology uses highly engineered T-cell receptors to precisely detect and target cytomegalovirus-infected cells, offering improved therapies and diagnostics by enhancing binding strength, stability, and resistance to viral immune evasion. Background Cytomegalovirus (CMV) is a widespread herpesvirus that poses significant health risks, particularly...
Published: 2/26/2026   |   Inventor(s): Jennifer Maynard, Ellen Wagner, Ahlam Qerqez, Annalee Nguyen
Keywords(s):  
Category(s): Life sciences > Immunology, Life sciences > Therapeutics
Aqueous Formulations of Cytotoxic Taxanes with Cyclodextrin
NU 2022-109 INVENTORS Brittney Williams Matthew Thompson Nathan Gianneschi* SHORT DESCRIPTION This invention describes aqueous formulations of cytotoxic taxane drugs conjugated to fatty acids, solubilized using cyclodextrin inclusion complexes, providing water-soluble chemotherapy formulations that eliminate the need for toxic organic solvents...
Published: 2/26/2026   |   Inventor(s):  
Keywords(s):  
Category(s): Life Sciences > Therapeutics
Methods of Using Modified Cytotoxins to Treat Cancer
NU 2019-135 INVENTORS Nathan Gianneschi* SHORT DESCRIPTION Methods for treating cancers that overexpress fatty acid uptake proteins using small-molecule cytotoxic drugs conjugated to long-chain fatty acid moieties. See also NU2022-111 and NU2022-109. BACKGROUND While prior work (under NU2022-111) demonstrated that lipid-mimicking cytotoxin...
Published: 2/26/2026   |   Inventor(s):  
Keywords(s): Cancer/Oncology, Small molecule, Therapeutics
Category(s): Life Sciences > Therapeutics
Modified Cytotoxins and their Therapeutic Use
NU 2022-111 INVENTORS Cassandra Callmann Matthew Thompson Clare LeGuyader Paul Bertin Nathan Gianneschi* SHORT DESCRIPTION This invention is for chemically modified small-molecule cytotoxic drugs conjugated to long-chain fatty acid-like hydrophobic moieties that bind non-covalently to albumin, creating improved cancer therapeutics with enhanced...
Published: 2/26/2026   |   Inventor(s):  
Keywords(s):  
Category(s): Life Sciences > Therapeutics
Cooperative Catalysis System for Enantioselective Transformations of Oxocarbenium Ions
NU 2019-063 INVENTORS Karl Scheidt* Mark Andrew Maskeri SHORT DESCRIPTION This invention introduces a cooperative catalysis system that enhances the reactivity and selectivity of oxocarbenium ions, facilitating new enantioselective transformations and enabling the synthesis of pharmacologically active tetrahydropyranoindole compounds. BACKGROUND...
Published: 2/24/2026   |   Inventor(s):  
Keywords(s):  
Category(s): Life Sciences > Therapeutics
Novel Serotonin Receptor Agonist to Treat Neurological Disease
NU 2018-135 INVENTORS Karl Scheidt* Adam Csakai Herbert Meltzer SHORT DESCRIPTION A novel small molecule that selectively targets serotonin 5-HT2c receptors for the treatment of psychiatric, mental, and/or neurological diseases. BACKGROUND Serotonin is a neurotransmitter known to regulate a variety of neurological functions, and alterations in...
Published: 2/24/2026   |   Inventor(s):  
Keywords(s): Neurodegenerative disease, Neurologic disease, Small molecule, Therapeutics
Category(s): Life Sciences > Therapeutics
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