Search Results - life+sciences+%3e+therapeutics

181 Results Sort By:
Selective DOT1L Protein Degraders for Precision Cancer Therapy
NU 2022-081 INVENTORS Sarki Abdulkadir (PI)* Gary Schiltz (PI)* SHORT DESCRIPTION A small molecule PROTAC technology that degrades DOT1L protein for targeted treatment of leukemia and prostate cancer. BACKGROUND Current cancer treatments, especially for MLL-rearranged leukemia and prostate cancer, face challenges of off-target effects and...
Published: 2/3/2026   |   Inventor(s):  
Keywords(s): Cancer/Oncology, Leukemia, Prostate cancer, PROTAC, Small molecule, Targeted protein degradation, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics
Covalent PRC2 Inhibitors for Advanced Cancer Therapeutics.
NU 2020-217 (NU 2020-215, NU 2020-216, NU 2020-217) INVENTORS Gary Schiltz (Weinberg College of Arts and Sciences, Department of Chemistry)* Jindan Yu (Feinberg School of Medicine, Department of Medicine (Hematology & Oncology Division))* - **Now at Emory** SHORT DESCRIPTION Covalent inhibitors and proteolysis-targeting chimera (PROTAC) degraders...
Published: 2/3/2026   |   Inventor(s):  
Keywords(s): Bladder cancer, Breast cancer, Cancer/Oncology, Covalent inhibitor, Lymphoma, Melanoma, Prostate cancer, PROTAC, Small molecule, Targeted protein degradation, Targeted therapy, Therapeutics
Category(s): Life Sciences > Therapeutics
Antibody compositions for improving detection and treatment of Bacillus anthracis infections
This technology uses specially designed antibodies with enhanced ability to detect or treat Bacillus anthracis infections, improving both diagnosis and therapy for anthrax. Background Bacillus anthracis, the causative agent of anthrax, is a highly virulent bacterium that poses significant threats to both public health and national security. Anthrax...
Published: 1/27/2026   |   Inventor(s): George Georgiou, Brent Iverson, Barrett Harvey
Keywords(s):  
Category(s): Life sciences > Immunology, Life sciences > Therapeutics
Transient Closed-Loop System for Autonomous Cardiac Electrotherapy
SHORT DESCRIPTION For cardiac care providers, this novel system integrates wireless, body-integrated devices to provide autonomous, temporary electrotherapy. It improves patient mobility while reducing healthcare risks and costs. INVENTORS Igor Efimov* Professor of Biomedical Engineering and Medicine (Division of Cardiology),...
Published: 1/30/2026   |   Inventor(s):  
Keywords(s):  
Category(s): Life Sciences > Healthcare Devices, Tools & IT, Life Sciences > Therapeutics
The use of complex or fusion protein of soluble MIC (Smic) and antibody to treat MIC-negative cancer
NU 2019-146 INVENTORS Jennifer Wu* SHORT DESCRIPTION A fusion protein complex comprising soluble MIC and a non-blocking sMIC-neutralizing antibody that effectively activates CD8 T cells for the treatment of MIC-negative cancer. BACKGROUND Effective T cell co-stimulation is critical for durable tumor control, yet many current immunotherapies...
Published: 12/9/2025   |   Inventor(s):  
Keywords(s): Antibody, Cancer/Oncology, Research tool
Category(s): Life Sciences > Therapeutics
Engineered B-cell Therapy for Cancer Treatment
NU 2022-218 INVENTORS Catalina Lee Chang* Maciej Lesniak* SHORT DESCRIPTION Engineered B cells with reduced expression of key immune checkpoint proteins designed to boost cancer immunotherapy efficacy. BACKGROUND Immunotherapy has transformed cancer treatment; however, its application to brain tumors remains limited by the immunosuppressive...
Published: 12/3/2025   |   Inventor(s):  
Keywords(s): Cancer/Oncology
Category(s): Life Sciences > Therapeutics
The Use of Annexins in Preventing and Treating Muscle Membrane Injury
NU 2018-119 INVENTORS Elizabeth McNally* Alexis Demonbreun SHORT DESCRIPTION An annexin-based biological therapeutic that enhances the body's natural cell membrane repair process to reduce muscle cell death and preserve tissue function. BACKGROUND Cell membrane integrity is critical for survival, especially in tissues under constant mechanical...
Published: 12/9/2025   |   Inventor(s):  
Keywords(s): Neurodegenerative disease, Therapeutics
Category(s): Life Sciences > Therapeutics
New Therapeutic Approach for the Treatment of Acute Myeloid Leukemia
NU 2017-214 Inventors Ali Shilatifard* Zibo Zhao Short Description A new therapeutic approach for the treatment of acute myeloid leukemia using casein kinase inhibitors. Background Leukemia is a group of cancers that affects the bone marrow and results in the overproduction of dysfunctional white blood cells (WBCs). The mixed lineage leukemia...
Published: 11/18/2025   |   Inventor(s):  
Keywords(s): Cancer/Oncology, Therapeutics
Category(s): Life Sciences > Therapeutics
Arylazanylpyrazolone Inhibition of Mutant SOD1 Mediated Cytotoxicity and Application to the Treatment of ALS
✅ Feedback form for Tech ID 2012-178 PROPOSED TITLE: Arylazanylpyrazolone Inhibition of Mutant SOD1 Cytotoxicity for ALS Treatment NU 2012-178 INVENTORS Richard Silverman* Yinan Zhang SHORT DESCRIPTION Compounds based on arylazanylpyrazolone derivatives inhibit mutant SOD1-mediated cytotoxicity, offering a promising approach for ALS treatment. BACKGROUND Amyotrophic...
Published: 11/18/2025   |   Inventor(s):  
Keywords(s): Therapeutics
Category(s): Life Sciences > Therapeutics
2-(Pyridin-3-yl)quinazoline compounds as glucocerebrosidase modulators
✅ Feedback form for Tech ID 2015-064 PROPOSED TITLE: 2-(Pyridin-3-yl) quinazoline Compounds as Glucocerebrosidase Modulators NU 2015-064 INVENTORS Richard Silverman* Dimitri Krainc Jianbin Zheng SHORT DESCRIPTION Novel substituted quinazoline compounds that modulate glucocerebrosidase activity, offering a promising therapeutic approach for...
Published: 11/18/2025   |   Inventor(s):  
Keywords(s): Neurodegenerative disease, Neurologic disease, PD - Parkinson's Disease, Research tool, Therapeutics
Category(s): Life Sciences > Therapeutics
1 2 3 4 5 6 7 8 9 10 ...