Search Results - life+sciences+%3e+therapeutics

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Cell-Free System For Tissue Regeneration
Cell-Free System for Tissue Regeneration NU2024-006 INVENTORS Mitali Kini Matthew Bury Arun Sharma* SHORT DESCRIPTION Total conditioned media (TCM) consisting of proteins and other molecules secreted from co-cultured human bone marrow mesenchymal stem cells (BM-MSCs) and CD34+ hematopoietic stem/progenitor cells (HSPCs) drive bladder tissue...
Published: 4/8/2025   |   Inventor(s):  
Keywords(s):  
Category(s): Life Sciences > Therapeutics
Advanced Haptic Actuators and Wearable Sensory Substitution Systems
NU 2024-099 INVENTORS John Rogers* SHORT DESCRIPTION A novel wearable haptic device that leverages a bistable electromechanical design and the skin’s natural elastic energy to deliver both dynamic and static stimuli. This technology transmits a range of tactile sensations, including pressure and twisting motions, for immersive and assistive...
Published: 4/2/2025   |   Inventor(s):  
Keywords(s): Bioelectronics, Electronics & Circuits, Flexible electronics, Haptic, Sensors, Sensory substitution, Wearable haptics
Category(s): Physical Sciences > Engineering & Technology, Physical Sciences > Software & Services, Life Sciences > Healthcare Devices, Tools & IT, Life Sciences > Therapeutics
Cell-type specific disruption of M1 muscarinic acetylcholine receptor expression to alleviate Parkinson's disease
NU 2024-244 INVENTORS Dalton J. Surmeier Jr* Tatiana Tkatch Shenyu Zhai SHORT DESCRIPTION Gene therapy targeting M1 muscarinic receptor expression in striatal spiny projection neurons to enhance levodopa response and slow Parkinson’s Disease progression. BACKGROUND Parkinson’s Disease (PD) is the second most common age-related...
Published: 4/4/2025   |   Inventor(s):  
Keywords(s): Neurodegenerative disease, Neurologic disease
Category(s): Life Sciences > Therapeutics
Gene therapy for levodopa-induced dyskinesia
NU 2024-086 INVENTORS Dalton J. Surmeier Jr* Weixing Shen Shenyu Zhai Tatiana Tkatch Qiaoling Cui Zhong Xie SHORT DESCRIPTION Gene therapy targeting GRIN2B in striatal spiny projection neurons to treat levodopa-induced dyskinesia. BACKGROUND Parkinson’s Disease (PD) is the second most common age-related neurodegenerative disease...
Published: 4/4/2025   |   Inventor(s):  
Keywords(s): Neurodegenerative disease, Neurologic disease, Neurology, Parkinson's Disease
Category(s): Life Sciences > Therapeutics
Targeting Calcium Channels to treat Early-Stage Parkinson’s Disease
NU 2024-179 INVENTORS Dalton J. Surmeier Jr* Jack Nguyen SHORT DESCRIPTION Novel compounds to inhibit Cav1.3 calcium channels and slow the progression of Parkinson's Disease. BACKGROUND Parkinson’s Disease (PD) is the second most common age-related neurodegenerative disease after Alzheimer’s Disease, affecting nearly one million...
Published: 4/4/2025   |   Inventor(s):  
Keywords(s): Neurodegenerative disease, Small molecule, Therapeutics
Category(s): Life Sciences > Therapeutics
Use of interferon-gamma antibody to reduce damage to the heart after myocardial infarction
Use of interferon-gamma antibody to reduce damage to the heart after myocardial infarction NU 2024-243 INVENTORS Hossein Ardehali* Sam E. Weinberg Amir Mahmoodzadeh SHORT DESCRIPTION Interferon-gamma antibodies to improve heart function after myocardial infarction (MI) BACKGROUND Myocardial infarction (MI) can trigger inflammation that...
Published: 4/4/2025   |   Inventor(s):  
Keywords(s):  
Category(s): Life Sciences > Therapeutics
Collagen IV binding Vascular Endothelial Growth Factor (VEGF) Bioconjugates for Vascularization
Collagen IV binding Vascular Endothelial Growth Factor (VEGF) Bioconjugates for Vascularization NU2022-150 INVENTORS Kyle M. Koss* Yangxi Liu Jason A. Wertheim* SHORT DESCRIPTION Bioconjugates that localize and concentrate VEGF within scaffold structures to support long-term cell survival and promote vascularization in tissue engineering...
Published: 4/4/2025   |   Inventor(s):  
Keywords(s):  
Category(s): Life Sciences > Therapeutics
Compositions and Methods for the Treatment of Intestinal Inflammation
NU 2021-252 INVENTORS Matthew Bury Muthukumar Gunasekaran Sunjay Kaushal Arun Sharma Tiffany Sharma BACKGROUND Crohn’s Disease (CD) is partly caused by a highly pro-inflammatory lesion microenvironment which subsequently causes numerous clinical complications. Northwestern University scientists have developed a method to control...
Published: 4/4/2025   |   Inventor(s):  
Keywords(s):  
Category(s): Life Sciences > Therapeutics
Small Molecule for Bladder Repair
NU 2021-153 INVENTORS Arun Sharma* Matthew Bury Natalie Fuller SHORT DESCRIPTION A small molecule to improve the regenerative outcomes of injured or diseased urinary bladder tissue ABSTRACT Northwestern researchers have identified a small molecule that facilitates the repair and restoration of damaged urinary bladder tissue following loss of...
Published: 4/4/2025   |   Inventor(s):  
Keywords(s): Drug discovery, Small molecule, Therapeutics, Urology
Category(s): Life Sciences > Therapeutics
Nanotherapy to Treat Intestinal Inflammation
NU 2015-160 PRIMARY INVENTOR Arun Sharma SHORT DESCRIPTION Potent anti-inflammatory nanomolecules to treat chronic intestinal inflammation (ileitis) that is detrimental to tissue function BACKGROUND Clinical complications of inflammatory bowel disease (IBD) such as Crohn’s disease (CD) can be observed throughout the digestive tract as tissue...
Published: 4/4/2025   |   Inventor(s):  
Keywords(s): Gastrointestinal and Hepatic disease, Inflammation, Small molecule, Therapeutics
Category(s): Life Sciences > Therapeutics
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