Search Results - life+sciences+%3e+therapeutics

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New Bacterial Nitric Oxide Synthase Inhibitors
NU 2014-182B INVENTORS Richard B Silverman* Soosung Kang SHORT DESCRIPTION New antibacterial compounds targeting bacterial nitric oxide synthase show promise against resistant bacterial strains. ABSTRACT Methicillin-resistant Staphylococcus aureus (MRSA) is a major cause of hospital-acquired infections. Furthermore, rates of morbidity and...
Published: 5/21/2025   |   Inventor(s):  
Keywords(s):  
Category(s): Life Sciences > Therapeutics
Bone-Promoting Thermoresponsive Macromolecules
PROPOSED TITLE Bone-Promoting Thermoresponsive Macromolecules NU 2016-201 INVENTORS Guillermo Ameer* Simona Morochnik SHORT DESCRIPTION Injectable, thermoresponsive PPCN-based hydrogels that are liquid at room temperature and gel at body temperature to provide controlled release of therapeutic agents and promote bone repair and formation. BACKGROUND The...
Published: 5/19/2025   |   Inventor(s):  
Keywords(s): Therapeutics
Category(s): Life Sciences > Therapeutics
Small molecule inhibits the interaction between tristetraprolin and CNOT1 for therapeutic use in metabolic disorders
NU 2024-057 INVENTORS Hossein Ardehali* Jason Shapiro SHORT DESCRIPTION Compound that inhibits the interaction between tristetraprolin (TTP) and CCR4-NOT Transcription Complex Subunit 1 (CNOT1) offers potential therapeutic avenue for metabolic disorders by modulating mRNA degradation without inflammatory side effects. BACKGROUND Metabolic disorders...
Published: 5/5/2025   |   Inventor(s):  
Keywords(s): Cardiology and Cardiovascular disease, Diabetes, Small molecule, Therapeutics
Category(s): Life Sciences > Therapeutics
Sliding Bioactive Peptides for Therapeutic Delivery
NU 2023-142 INVENTORS Samuel I. Stupp* Federico Lancia Madison E. Strong Matias A. Alvarez-Saavedra SHORT DESCRIPTION This technology involves the design and engineering of peptide amphiphile nanofibers that deliver bioactive peptides both extra- and intra-cellularly. The bioactive peptides can slide along these structures...
Published: 5/2/2025   |   Inventor(s):  
Keywords(s): Biomaterials, Drug delivery
Category(s): Life Sciences > Therapeutics
Improved MEK4 Inhibitors for the Treatment of Cancer
NU 2021-217 INVENTORS Karl Scheidt* Ada Jade Kwong Hidayatullah Munshi Thao Nguyen Pham SHORT DESCRIPTION This technology introduces novel indazole derivatives as potent and selective MEK4 inhibitors for cancer treatment, particularly in advanced prostate cancer and pancreatic adenocarcinoma. The lead molecule is optimized over first-generation...
Published: 4/23/2025   |   Inventor(s):  
Keywords(s):  
Category(s): Life Sciences > Therapeutics
3-Arylindazoles as Selective MEK4 Inhibitors
NU 2019-059 INVENTORS Karl Scheidt* Matthew Clutter Ada Jade Kwong Gary Schiltz SHORT DESCRIPTION This technology discloses novel 3-arylindazole compounds as highly potent and selective MEK4 inhibitors for treating various cancers, including metastatic prostate cancer. The compounds offer promise both as clinical agents and valuable chemical...
Published: 4/23/2025   |   Inventor(s):  
Keywords(s):  
Category(s): Life Sciences > Therapeutics
Cell-Free System For Tissue Regeneration
Cell-Free System for Tissue Regeneration NU2024-006 INVENTORS Mitali Kini Matthew Bury Arun Sharma* SHORT DESCRIPTION Total conditioned media (TCM) consisting of proteins and other molecules secreted from co-cultured human bone marrow mesenchymal stem cells (BM-MSCs) and CD34+ hematopoietic stem/progenitor cells (HSPCs) drive bladder tissue...
Published: 4/24/2025   |   Inventor(s):  
Keywords(s):  
Category(s): Life Sciences > Therapeutics
Advanced Haptic Actuators and Wearable Sensory Substitution Systems
NU 2024-099 INVENTORS John Rogers* SHORT DESCRIPTION A novel wearable haptic device that leverages a bistable electromechanical design and the skin’s natural elastic energy to deliver both dynamic and static stimuli. This technology transmits a range of tactile sensations, including pressure and twisting motions, for immersive and assistive...
Published: 4/23/2025   |   Inventor(s):  
Keywords(s): Bioelectronics, Electronics & Circuits, Flexible electronics, Haptic, Sensors, Sensory substitution, Wearable haptics
Category(s): Physical Sciences > Engineering & Technology, Physical Sciences > Software & Services, Life Sciences > Healthcare Devices, Tools & IT, Life Sciences > Therapeutics
Cell-type specific disruption of M1 muscarinic acetylcholine receptor expression to alleviate Parkinson's disease
NU 2024-244 INVENTORS Dalton J. Surmeier Jr* Tatiana Tkatch Shenyu Zhai SHORT DESCRIPTION Gene therapy targeting M1 muscarinic receptor expression in striatal spiny projection neurons to enhance levodopa response and slow Parkinson’s Disease progression. BACKGROUND Parkinson’s Disease (PD) is the second most common age-related...
Published: 4/24/2025   |   Inventor(s):  
Keywords(s): Neurodegenerative disease, Neurologic disease
Category(s): Life Sciences > Therapeutics
Gene therapy for levodopa-induced dyskinesia
NU 2024-086 INVENTORS Dalton J. Surmeier Jr* Weixing Shen Shenyu Zhai Tatiana Tkatch Qiaoling Cui Zhong Xie SHORT DESCRIPTION Gene therapy targeting GRIN2B in striatal spiny projection neurons to treat levodopa-induced dyskinesia. BACKGROUND Parkinson’s Disease (PD) is the second most common age-related neurodegenerative disease...
Published: 4/24/2025   |   Inventor(s):  
Keywords(s): Neurodegenerative disease, Neurologic disease, Neurology, Parkinson's Disease
Category(s): Life Sciences > Therapeutics
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