Search Results - life+sciences+%3e+therapeutics

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Covalent ERK inhibitors for suppressing cancer
BI-78D3, a small molecule, covalently binds to ERK1/2’s D-recruitment site, disrupting ERK signaling crucial for cancer cell growth. This shows promise for treating ERK-dependent cancers, including those resistant to BRAF inhibitors. This disrupts ERK signaling crucial for cell proliferation and survival, particularly in certain cancers like...
Published: 11/8/2024   |   Inventor(s): Kevin Dalby, Ramakrishna Edupuganti, Tamer Kaoud, Chelsea Massaro
Keywords(s):  
Category(s): Life sciences > Therapeutics > Drug delivery, Life sciences > Therapeutics
Lipid nanocarriers for promoting angiogenesis
This invention describes a new way to deliver a protein called transmembrane stem cell factor (tmSCF) using tiny carriers made of lipids (fats). This helps promote the growth of new blood vessels and could treat peripheral vascular disease. Background Peripheral vascular disease (PVD) affects a significant portion of the aging population, often leading...
Published: 10/23/2024   |   Inventor(s): Aaron Baker, Eri Takematsu
Keywords(s):  
Category(s): Life sciences > Therapeutics > Biologic, Life sciences > Therapeutics
Cellulose nanofiber spray for enhanced filtration efficiency
This invention is a water-soluble, biodegradable, and biocompatible spray composed of cellulose nanofibers and polyvinyl alcohol that enhances the filtration efficiency of textiles by creating a protective layer that can break the membranes of pathogens. Background The need for effective filtration systems, particularly in personal protective equipment...
Published: 10/22/2024   |   Inventor(s): Jonathan Chen, Sophia Jackson
Keywords(s):  
Category(s): Life sciences > Medical technology, Life sciences > Therapeutics
Advanced Cancer Therapeutic Targeting Removal of H2O2 in Cell Nuclei
NU2023-013 INVENTORS Marcelo Bonini BACKGROUND Northwestern University Scientists have developed a potential therapeutic to treat advanced stage cancers. It has been shown that in cancer cells, hydrogen peroxide oxidizes histone H3.1. Removal of this hydrogen perioxide from the nucleus of cancer cells with NLS-catalase protected H3.1 was...
Published: 10/17/2024   |   Inventor(s):  
Keywords(s):  
Category(s): Life Sciences > Therapeutics
Electrical modulation for the treatment of brain tumors
NU2022-229 INVENTORS Timothy Sita* BACKGROUND Glioblastoma (GBM) is a type of incurable brain tumor with poor prognosis. Despite a combination of treatments, including surgery, radiation, and chemotherapy, most patients do not survive longer than two years following diagnosis. GBM and other types of brain tumors hijack our brain’s...
Published: 11/13/2024   |   Inventor(s):  
Keywords(s):  
Category(s): Life Sciences > Therapeutics
Revolutionizing Lung Transplantation - A Comprehensive Approach to Combatting Primary Graft Dysfunction
NU 2022-147 INVENTOR Ankit Bharat* Emilia Lecuona Wenbin Yang BACKGROUND Primary graft dysfunction (PGD) is a critical barrier to successful lung transplantation. Our research identifies pre-existing lung autoantibodies as key contributors to PGD, opening new avenues for prevention and treatment. We propose a streamlined tri-fold approach...
Published: 10/17/2024   |   Inventor(s):  
Keywords(s):  
Category(s): Life Sciences > Therapeutics
PROTACs for TG2 Degradation
NU2022-106 INVENTORS Gary Schiltz* Daniela Matei* BACKGROUND Proteolysis-targeting chimeric molecules (PROTACs) are an emergent form of technology that may be utilized to target previously “undruggable” targets, transcription factors, and non-enzymatic proteins related to disease. Despite the increased use of PROTACs to leverage...
Published: 10/17/2024   |   Inventor(s):  
Keywords(s):  
Category(s): Life Sciences > Therapeutics
Compositions and Methods for the Treatment of Intestinal Inflammation
NU 2021-252 INVENTORS Matthew Bury Muthukumar Gunasekaran Sunjay Kaushal Arun Sharma Tiffany Sharma BACKGROUND Crohn’s Disease (CD) is partly caused by a highly pro-inflammatory lesion microenvironment which subsequently causes numerous clinical complications. Northwestern University scientists have developed a method to control...
Published: 10/17/2024   |   Inventor(s):  
Keywords(s):  
Category(s): Life Sciences > Therapeutics
A CSF-derived therapy for psychiatric disorders
NU2023-196 INVENTORS Peter Penzes* Marc Dos Santos BACKGROUND Currently, there is a lack of treatments which address the negative and cognitive symptoms of psychiatric disorders such as schizophrenia. Northwestern researchers have designed a recombinant form of ⍺2d-1 protein, a subunit of the voltage-gated calcium channel, to restore protein...
Published: 10/17/2024   |   Inventor(s):  
Keywords(s): Biologic, Psychiatric disease, Therapeutics
Category(s): Life Sciences > Therapeutics
CAR T Cells Armored with IL15 for Treating Glioblastoma
NU 2022-074 INVENTORS Irina V. Balyasnikova* BACKGROUND Glioblastoma is a devastating brain cancer for which no effective treatment exists, leading to short patient survival. Although investigations are underway to explore chimeric antigen receptor T (CAR-T) cells as glioblastoma therapy, the immunosuppressive tumor microenvironment (TME) in...
Published: 10/17/2024   |   Inventor(s):  
Keywords(s):  
Category(s): Life Sciences > Therapeutics
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