Search Results - life+sciences+%3e+therapeutics

134 Results Sort By:
MEK7 inhibitors for acute lymphoblastic leukemia (ALL) treatment
NU 2023-060 INVENTORS Karl Scheidt* Dalton Kim Meghan Orr SHORT DESCRIPTION Rational design of highly potent and selective covalent MEK7 inhibitors BACKGROUND Acute lymphoblastic leukemia (ALL) is a deadly blood cancer, the most common hematological malignancy in patients under 14 years of age. Despite advancements in treatment, ALL relapse...
Published: 9/12/2024   |   Inventor(s):  
Keywords(s):  
Category(s): Life Sciences > Therapeutics
Self-assembling peptides with hyaluronic acid binding domains to form hydrogels
NU 2022-016 INVENTORS Kyle M. Koss Terrance J. Sereda* Jason A. Wertheim* ABSTRACT A new class of self-assembling peptides with hyaluronic acid-binding domains shows great promise for biomedical applications, particularly in treating injuries, cancer, and enhancing the function of implantable devices. These peptides self-assemble into nanofibers...
Published: 9/10/2024   |   Inventor(s):  
Keywords(s):  
Category(s): Life Sciences > Therapeutics
Self-Manageable Abnormal Scar Treatment with Spherical Nucleic Acids (SNAs) Technology
NU 2018-071 INVENTORS Anthony Sprangers Shengshuang Zhu Adam Ponedal Chad Mirkin* ABSTRACT A self-administrable scar treatment based on spherical nucleic acids (SNAs) that penetrates skin and suppressed TGFβ1 expression to prevent abnormal scar formation. Non-invasive and offers patients an accessible, painless solution for scar care...
Published: 9/10/2024   |   Inventor(s):  
Keywords(s): Therapeutics
Category(s): Life Sciences > Therapeutics
Nanoparticle technology for targeted therapeutic and diagnostic delivery
The invention involves nanoparticles for targeted delivery of therapeutic and diagnostic agents. These nanoparticles accumulate in specific tissues, disintegrate upon stimuli, and release active agents, enhancing treatment specificity and efficacy while minimizing systemic effects. Background Nanoparticles have their potential to revolutionize drug...
Published: 9/10/2024   |   Inventor(s): Zhengrong Cui, Abdulaziz Aldayel
Keywords(s):  
Category(s): Life sciences > Therapeutics
Aesthetics and Wound Healing-related Technologies
NU2014-173; NU2014-168; NU2015-071; NU2015-101; NU2017-011; NU2018-071; NU2018-151; NU2020-033; NU2020-249; NU2022-016; NU2022-079; NU2024-094 Transform your wound care and tissue repair solutions with our portfolio of technologies that provide cutting-edge solutions for wound care, tissue engineering, and disease treatment. This includes hydrogels...
Published: 9/10/2024   |   Inventor(s):  
Keywords(s): Adhesive, Biomedical, Biotechnology, General surgery, Hydrogel, Wound Healing
Category(s): Life Sciences > Therapeutics, Life Sciences > Healthcare Devices, Tools & IT
New Lipiodol Formulation for Treating Hepatocellular Carcinoma with Transarterial Chemoimmunoembolization
NU 2021-148 INVENTORS Dong Hyun Kim* Heegon Kim SHORT DESCRIPTION A new Lipiodol formulation designed to improve the efficacy and safety of transarterial chemoembolization in combination with immunotherapy. BACKGROUND Transarterial chemoembolization...
Published: 9/4/2024   |   Inventor(s):  
Keywords(s): Cancer/Oncology, Drug delivery, Gastrointestinal and Hepatic disease, Immunotherapy, Therapeutics
Category(s): Life Sciences > Therapeutics
Novel Therapeutics for Pediatric Embryonal Tumors Using PLK4 inhibitors
LU 2017-124 INVENTORS Simone T. Sredni* Tadanori Tomita SHORT DESCRIPTION Embryonal tumors such as malignant rhabdoid tumors (MRTs) are aggressive and frequently metastatic embryonal tumors of infancy. However, available therapies often elicit modest anti-tumor response leading to poor survival, or induce highly toxicity in patients of young...
Published: 8/26/2024   |   Inventor(s):  
Keywords(s): Therapeutics
Category(s): Life Sciences > Therapeutics
Peptide Amphiphiles for Sonic Hedgehog Regulation of Pelvic Nerves for Treatment of Stress Urinary Incontinence and Erectile Dysfunction
NU 2018-075, 2018-076, 2018-077 INVENTORS Caroline Podlasek Kevin McVary Daniel Harrington Samuel Stupp* SHORT DESCRIPTION Novel peptide amphiphile (PA) nanofiber hydrogel is used to deliver sonic hedgehog (SHH) protein to nerves of the major pelvic ganglia and the rhabdospincter as a treatment for erectile dysfunction and urinary incontinence. BACKGROUND Urinary...
Published: 7/11/2024   |   Inventor(s):  
Keywords(s): Materials, Therapeutics
Category(s): Life Sciences > Therapeutics
Therapy for acute kidney injury
NU 2022-202 INVENTORS Pinelopi Kapitsinou* Ratnakar Tiwari SHORT DESCRIPTION Inhibition of MCT4 slows the progression of acute kidney inury to chronic kidney disease BACKGROUND Acute kidney inury (AKI) is a sudden onset of kidney dysfunction, often caused by factors such as ischemia, toxins, or infections, leading to impaired filtration and accumulation...
Published: 8/26/2024   |   Inventor(s):  
Keywords(s): Inflammation, Renal Disease, Therapeutics
Category(s): Life Sciences > Therapeutics
Human Spinal Cord Injury Organoids for Therapeutic Discovery
NU 2023-116 INVENTORS Nozomu Takata Nicholas Sather Samuel Stupp* SHORT DESCRIPTION A human organoid model to simulate spinal cord injury in vitro and test potential therapeutics. BACKGROUND Injury in organs triggers cellular and molecular rearrangements that induce intrinsic repair and regeneration, but the human central nervous system has...
Published: 7/24/2024   |   Inventor(s):  
Keywords(s):  
Category(s): Life Sciences > Therapeutics
1 2 3 4 5 6 7 8 9 10 ...