Magnetohydrodynamic clearing and antibody staining

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­PRODUCT OPPORTUNITIES

Devices and methods for moving charged molecules into and out of tissue samples

PRODUCT OPPORTUNITIES

COMPETITIVE ADVANTAGES

• Significantly reduces the time required to clear tissue samples
• Significantly reduces the time required for histological procedures in large tissue samples
• Removes biomarkers from tissue samples
• Minimizes overall damage to the biological tissue samples
• Maximizes quality of biological tissue samples
• Allows deeper penetration/analysis of biological tissue
• Allows for multiple rounds of histological staining and de-staining in a single sample
• Low-cost of production and durable device

TECHNOLOGY DESCRIPTION

This invention provides devices and methods for the interrogation of molecular structure and function of virtually any biological tissue  by allowing histological analyses of large biological tissues with numerous biomarkers (antibodies, RNAs, chemical labels). In addition, this technique maintains the integrity of large tissue samples making it possible to perform multiple rounds of histological staining to resolve 3-D organization of biological structures at the macroscopic and microscope scale.

ABOUT THE INVENTOR

Joseph Began is an Associate Professor in the Department of Psychological and Brain Sciences at the University of Massachusetts Amherst. His research focuses on behavioral neuroscience where they seek to understand the principles of how social and defensive stimuli are encoded in the activity of neurons and how this process can be modulated by behavior state, experience, and neuromodulation.

AVAILABILITY:

Available for Licensing and/or Sponsored Research

DOCKET:

UMA 17-049

PATENT STATUS:

Patent Issued US 11,863,041 B2

NON-CONFIDENTIAL INVENTION DISCLOSURE

LEAD INVENTOR:

Joseph Bergan Ph.D

CONTACT:

This invention provides devices and methods for the interrogation of molecular structure and function of virtually any biological tissue  by allowing histological analyses of large biological tissues with numerous biomarkers (antibodies, RNAs, chemical labels). In addition, this technique maintains the integrity of large tissue samples making it possible to perform multiple rounds of histological staining to resolve 3-D organization of biological structures at the macroscopic and microscope scale.