Search Results - lawrence+pfeffer

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Benzylthiophene Derivatives
 
Published: 6/17/2022   |   Inventor(s): Lawrence Pfeffer, Yinan Wang, Chuan Yang
Keywords(s): Cancer, Cancer therapeutics, Oncology
Category(s): Human Health
Knockdown of miR-21 Expression Sensitizes Cancer Cell to Apoptosis Induced by Interferon
The micro RNA, miR-21, is overexpressed in many human cancers, and accumulating evidence indicates that miR-21 has oncogenic activity. Here we report that the cytokine IFNa/b rapidly induced the miR-21 transcript in several human and mouse cell lines. Pathways known to be involved in regulating cell death were identified as downstream targets for miR-21,...
Published: 4/27/2022   |   Inventor(s): Lawrence Pfeffer, Chuan Yang, Junming Yue, Charles Handorf
Keywords(s): Research Tools and Reagents
Category(s): Human Health, Research Tools
Establishing a murine cell line with high human IFNAR1 expression to characterize type I interferon ligand binding
A mouse cell line was established by transfection that stably expresses the human IFNAR1 chain with various portions of the intracellular domain deleted. The cell line can be used in human interferon bioassays such as ligand binding and antiviral assays.
Published: 12/6/2022   |   Inventor(s): Lawrence Pfeffer
Keywords(s): Research Tools and Reagents
Category(s): Research Tools, Human Health
Bromodomaine Inhibitors to Target Therapy-Resistant Cancer
The Problem:Glioblastoma multiforme (GBM) is the most common and the most aggressive malignant brain tumor in adults, having an overall incidence of approximately three new cases per 100,000 persons per year. Presently, GBM is highly lethal, with a median survival of 14 to15 months after diagnosis and no effective treatment for a significant long-term...
Published: 4/27/2022   |   Inventor(s): Duane Miller, Lawrence Pfeffer, Yali He, Debolina Ganguly
Keywords(s): Cancer, Cancer therapeutics, Therapeutics
Category(s): Human Health