Search Results - research+tools+and+reagents

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Knockdown of miR-21 Expression Sensitizes Cancer Cell to Apoptosis Induced by Interferon
The micro RNA, miR-21, is overexpressed in many human cancers, and accumulating evidence indicates that miR-21 has oncogenic activity. Here we report that the cytokine IFNa/b rapidly induced the miR-21 transcript in several human and mouse cell lines. Pathways known to be involved in regulating cell death were identified as downstream targets for miR-21,...
Published: 4/27/2022   |   Inventor(s): Lawrence Pfeffer, Chuan Yang, Junming Yue, Charles Handorf
Keywords(s): Research Tools and Reagents
Category(s): Human Health, Research Tools
Establishing a murine cell line with high human IFNAR1 expression to characterize type I interferon ligand binding
A mouse cell line was established by transfection that stably expresses the human IFNAR1 chain with various portions of the intracellular domain deleted. The cell line can be used in human interferon bioassays such as ligand binding and antiviral assays.
Published: 12/6/2022   |   Inventor(s): Lawrence Pfeffer
Keywords(s): Research Tools and Reagents
Category(s): Research Tools, Human Health
A New Oxyma Derivative for Amide-Forming Reactions in Water
Reference: PD 12110Technical Field:Research Tool: Chemical ReagentBackground:In amide-forming reactions with R-amino acids, the use of a coupling additive such as benzotriazole derivatives [e.g., 1-hydroxy-7-azabenzotriazole (HOAt) and hydroxybenzotriazole (HOBt)] is essential to suppress racemization and improve the efficacy of peptide synthesis.Oxyma,...
Published: 9/23/2020   |   Inventor(s): Michio Kurosu, Qinghui Wang, Yong Wang
Keywords(s): Chemical reagent, Peptide synthesis, Peptides, Research Tools and Reagents
Category(s): Chemistry & Materials