Search Results - kejian+zhang

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Method for 3D Nonlinear Structured Illumination Super-resolution Imaging

Researchers at the University of Arizona have developed a super-resolution microscopy method that is faster, easier to use, and has less artifacts than current super-resolution methods. The result is a 3D dual-color stimulated emission depletion (STED) nonlinear structured illumination (NL-SIM) microscope. Using a combination of low coherent light and...

Published: 4/3/2023 | Inventor(s): Leilei Peng, Yu Li, Han Zhang

Keywords(s):

Category(s): Technology Classifications > Imaging & Optics, Technology Classifications > Imaging & Optics > Medical Imaging, Technology Classifications > Imaging & Optics > Microscopy, Spectroscopy, Polarimetry

Making Oligonucleotides Better Biopharmaceuticals with Brush Polymer-Assisted Compaction

INV-16006 Background Oligonucleotide-based gene therapy holds tremendous promise for treating a variety of disorders with a genetic basis, including cancers, neurological diseases, and metabolic conditions. However, due to difficulties including poor accumulation at target sites, removal by immune responses, nuclease degradation, and low biochemical...

Published: 9/10/2024 | Inventor(s): Ke Zhang, Xueguang Lu

Keywords(s):

Category(s): -Chemistry, -Cancer, Technology Classifications > 1. Life Science, Technology Classifications > 1. Life Science > Biotechnology, Technology Classifications > 1. Life Science > Drug Delivery

Oligonucleotide-based therapeutics targeting COVID-19

Background Oligonucleotides (ONs) are a promising class of agents in the fight against a wide variety of diseases including cancers, neuropathies, and metabolic disorders. Despite decades of research results indicating widespread clinical success, the therapeutic use of ONs have yet to be realized, which is somewhat due to the bio-pharmaceutical difficulties...

Published: 9/10/2024 | Inventor(s): Ke Zhang

Keywords(s): COVID

Category(s): -Sensors, Technology Classifications > 1. Life Science > Therapeutics

Bi-Functional RGD Peptide and a Co-Signaling Mechanism to Promote Therapeutic Angiogenesis

Bi-Functional RGD Peptide to Promote Therapeutic Angiogenesis, Treat Ischemic Diseases Technology: While previous studies have focused on the identification of biological ligands to improve the functions of endothelial cells, MUSC and Clemson University researchers have combined modern bioinformatics and a newly established peptide functionalized...

Published: 3/23/2023 | Inventor(s): Chung-Jen (James) Chou, Ying Mei, Jia Jia

Keywords(s):

Category(s): BioPharma

Cold Sterilization of Tissue Engineering Scaffolds with Compressed Carbon Dioxide

Reference #: 00774The University of South Carolina is offering licensing opportunities for this technologyInvention Description:A process for sterilizing tissue engineering materials by using compressed carbon dioxide into which selected additives have been incorporated. This method is effective for sterilizing complex structures, without causing adverse...

Published: 6/4/2018 | Inventor(s): Michael Matthews, Jian Zhang, Aidaris Jimenez

Keywords(s):

Category(s): Biomedical and Life Sciences

Methods and Compositions for Inactivating Allergens and Allergen-Producing Organisms

Reference #: 00690The University of South Carolina is offering licensing opportunities for this technologyPotential Applications:This technology has the potential to be used on a full-scale industrial level for purposes such as home carpet cleaning.Advantages and Benefits:With the combination of killing and removing dust mites and dust mite feces, indoor...

Published: 2/2/2018 | Inventor(s): Michael Matthews, Jian Zhang

Keywords(s):

Category(s): Chemistry and Biochemistry

Personalized Pain Management Diagnostic

This technology evaluated more than 70 relevant SNPs for their clinical utility in determining inter-individual variability in response to a dose of morphine and opioids. By confirming many of the previous genotype-phenotype associations reported in literature, our researchers have found several strong novel associations with clinical outcome measures,...

Published: 10/18/2023 | Inventor(s): Senthilkumar Sadhasivam, Vidya Chidambaran, John Mcauliffe, Kejian Zhang

Keywords(s): 1 - Diagnostic, Diagnostic Tests, Therapeutic Interventions

Category(s): Diagnostics