This technology evaluated more than 70 relevant SNPs for their clinical utility in determining inter-individual variability in response to a dose of morphine and opioids. By confirming many of the previous genotype-phenotype associations reported in literature, our researchers have found several strong novel associations with clinical outcome measures, gene-gene interactions and gene-non-genetic factor interactions which are critical in connecting clinically important dots in predicting and personalizing care and reducing adverse clinical and economical outcomes in children and adults.