Search Results - 1+-+diagnostic

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This technology evaluated more than 70 relevant SNPs for their clinical utility in determining inter-individual variability in response to a dose of morphine and opioids. By confirming many of the previous genotype-phenotype associations reported in literature, our researchers have found several strong novel associations with clinical outcome measures,...

Published: 10/18/2023 | Inventor(s): Senthilkumar Sadhasivam, Vidya Chidambaran, John Mcauliffe, Kejian Zhang

Keywords(s): 1 - Diagnostic, Diagnostic Tests, Therapeutic Interventions

Category(s): Diagnostics

SapC-DOPS Agents in Imaging Arthritis

(CHMC Ref. Id: 2011-0503) Overview: Rheumatoid arthritis (RA) is a chronic inflammatory disease that affects about 1% of the population and is characterized by the destruction of cartilage and bone ultimately leading to loss of joint function. To date, reliable and non-invasive techniques that accurately measure arthritic disease onset and progression...

Published: 8/7/2018 | Inventor(s): Sherry Thornton, Xiaoyang Qi, Matthew Flick

Keywords(s): 1 - Diagnostic, Inflammation/Immunity/Immune Therapy, Protein Sci/Structural Bio/Medicinal Che

Category(s): Diagnostics

Simultaneous ASL/BOLD Functional MRI

This technology can provide a fundamental building block for studies of functional neuropathology in subjects using functional MR methods. Abnormalities in the neural substrates of attention, language, and memory may be better understood against the backdrop of normal age-dependent trends. Arterial spin labeling (ASL) functional imaging provides...

Published: 10/10/2019 | Inventor(s): Scott Holland, Vincent Schmithorst, Jennifer Vannest, Luis Hernandez-Garcia

Keywords(s): 1 - Diagnostic, Diagnostic Tests

Category(s): Diagnostics

Diagnostic for Progression of Fatty Liver Disease

Diagnostic for Progression of Fatty Liver Disease (CHMC Ref. Id: 2009-1204) Overview: Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide today. However, there is currently no widely validated and reliable non-invasive biomarker for fibrosis progression in non-alcoholic steatohepatitis (NASH), the...

Published: 5/14/2024 | Inventor(s): Rohit Kohli, Michael Miles, Stavra Xanthakos

Keywords(s): 1 - Diagnostic, Diagnostic Tests, Protein Sci/Structural Bio/Medicinal Che, Systems Biology

Category(s): Diagnostics

IL-13 Induced Gene Signature for Eosinophilic Esophagitis

IL-13 Induced Gene Signature for Eosinophilic Esophagitis (CHMC Ref. Id: 2007-0811) Overview: Eosinophilic esophagitis (EE) is an emerging worldwide disease. The current treatment for EE is with swallowed glucocorticoids, however, only a subset of EE patients experience remission from the disease following treatment with topical steroids. Dr....

Published: 8/20/2018 | Inventor(s): Marc Rothenberg

Keywords(s): 1 - Diagnostic, Diagnostic Tests, Genomics/Epigenomics, Inflammation/Immunity/Immune Therapy

Category(s): Diagnostics

Lupus Nephritis Diagnostic Biomarker Panel

Four renal biomarkers: transferrin (TF), ceruloplasmin (Cp), lipocalin-type prostaglandin-D synthetase (L-PGDS), and alpha-1-acid glycoprotein (AGP), are capable of accurately diagnosing and determining the course of LN in both children and adults with systemic lupus erythematosis (SLE). While each individual biomarker can be used alone, the combination...

Published: 9/11/2022 | Inventor(s): Prasad Devarajan, Hermine Brunner

Keywords(s): 1 - Diagnostic, Diagnostic Tests, Genomics/Epigenomics

Category(s): Diagnostics

Serum Biomarker for Stratifying Patients in Septic Shock Clinical Trials

Overview: Currently, there exists no method for stratifying pediatric septic shock clinical trial candidates. Specifically, there is no way to eliminate patients that would have a high likelihood of a positive outcome with standard care from these trials. Dr. Wong at Cincinnati Children's Hospital has demonstrated that there is a marked increase...

Published: 8/20/2018 | Inventor(s): Hector Wong

Keywords(s): 1 - Diagnostic, Diagnostic Tests, Health Serv/Outcomes/Quality/Sys Improv

Category(s): Diagnostics

Diagnostic and Prognostic for Crohn's Disease and Ulcerative Colitis

Diagnostic and Prognostic for Crohn's Disease and Ulcerative Colitis (CHMC Ref. Id: 2007-0105) Overview: Several defects in neutrophil function have been noted in Crohn's Disease (CD), including reduced phagocytosis, adhesion, chemotaxis, and oxidative burst. This has been shown to reduce neutrophil accumulation at sites of injury, promoting...

Published: 10/31/2023 | Inventor(s): Lee Denson, Bruce Trapnell, Kanji Uchida

Keywords(s): 1 - Diagnostic, Diagnostic Tests, Genomics/Epigenomics, Health Serv/Outcomes/Quality/Sys Improv, Inflammation/Immunity/Immune Therapy, Protein Sci/Structural Bio/Medicinal Che, Systems Biology

Category(s): Diagnostics

Diagnostic and Prognostic for Crohn's Disease

Diagnostic and Prognostic for Crohn's Disease (CHMC Ref. Id: 2006-0202) Overview: Standard therapies for IBD include steroids and immunomodulators which lead to a sustained remission in approximately 50% of patients. Currently, there are no reliable predictors of response, leading Dr. Denson and colleagues to prepare and stratify patient...

Published: 2/8/2023 | Inventor(s): Lee Denson, Bruce Aronow, Huan Xu

Keywords(s): 1 - Diagnostic, Diagnostic Tests, Genomics/Epigenomics, Health Serv/Outcomes/Quality/Sys Improv, Inflammation/Immunity/Immune Therapy, Systems Biology

Category(s): Diagnostics

Expression Profile for Acute Childhood Asthma

Asthma is the most common chronic disease of childhood and has a strong genetic component. This technology identifies gene expression signatures that differentiate stable asthma and acute exacerbations. Researchers profiled gene expression patterns in nasal respiratory epithelial cells from children who had stable asthma, those experiencing asthma exacerbation,...

Published: 6/28/2022 | Inventor(s): Gurjit Hershey, Bruce Aronow, Marsha Wills-Karp

Keywords(s): 1 - Diagnostic, Diagnostic Tests, Genomics/Epigenomics

Category(s): Diagnostics

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