Search Results - junfeng+wang%2c

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Telaprevir-derived Enterovirus D68 2A protease inhibitors are antiviral drug candidates
Published data for lead compounds, the telaprevir-derived 2Apro inhibitor Jun11762 and others, demonstrate substantial improvement over Telaprevir in plaque assay. See link to paper below. ​ Invention Summary: The genus Enterovirus of Picornaviridae contains many significant pathogens related to human and mammalian diseases. Enterovirus D68...
Published: 7/31/2025   |   Inventor(s): Jun Wang, Bin Tan, Prakash Jadhav, Kan Li
Keywords(s): Antiviral, Small molecules
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Infectious Disease, Technology Classifications > Therapeutics
Fumaramide SARS-CoV-2 papain-like protease inhibitors are antiviral drug candidates
​ Published data for lead compound, the fumaramide PLpro inhibitor Jun13728, demonstrate potent inhibition of SARS-CoV2 variants including nirmatrelvir-resistant mutant (light blue). Link to paper below. Invention Summary: The COVID-19 pandemic significantly accelerated the development of antiviral therapies and vaccines. Recent efforts for...
Published: 7/31/2025   |   Inventor(s): Jun Wang, Bin Tan, Prakash Jadhav, Ahmadullah Ansari, Francesc Ruiz Figueras, Edward Arnold
Keywords(s):  
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Therapeutics
Quinoline-derived SARS-CoV-2 papain-like protease inhibitors are oral antiviral drug candidates
​ A lead compound, the quinoline-derived PLpro inhibitor Jun13296, demonstrates substantial protection against SARS-CoV-2 infection and adverse clinical outcomes. Invention Summary: The COVID-19 pandemic significantly accelerated the development of antiviral therapies and vaccines. Recent efforts for research to support pandemic preparedness...
Published: 7/31/2025   |   Inventor(s): Jun Wang, Prakash Jadhav, Bin Tan, Haozhou Tan
Keywords(s): Antiviral
Category(s): Technology Classifications > COVID-19, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Infectious Disease, Technology Classifications > Therapeutics
Enterovirus D68 capsid inhibitors as antivirals
​ Plaque assay results of Jun11-46-1 and Jun11-54-1 against EV-D68 US/MO/14-18947. Invention Summary: Enterovirus D68 (EV-D68) is an RNA virus that mainly affects children and results in moderate to severe respiratory illness, with the most extreme cases resulting in muscle weakness, paralysis, and death. Currently, there are no antivirals...
Published: 1/27/2025   |   Inventor(s): Jun Wang, Yanmei Hu, Kan Li
Keywords(s): Antibacterial, Small molecules
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Infectious Disease, Technology Classifications > Therapeutics
Wearable tongue tracker for silent speech interfaces
MagTrack is a lightweight, wearable device that utilizes magnetic fields to track tongue movements, enabling silent speech recognition and other applications like speech therapy. Background Silent speech interfaces (SSIs) aim to restore communication for individuals who have lost their voice but retain the ability to articulate, such as those who...
Published: 10/23/2024   |   Inventor(s): Jun Wang, Beiming Cao
Keywords(s):  
Category(s): Life sciences > Diagnostic, Life sciences > Imaging
Simulation-based Real-time Production Control
In many production systems like semiconductor manufacturing, food industry, and battery production, the amount of time a part can spend in successive buffers is limited in many production systems because of possible quality concerns. If a part's residence time exceeds these limits, it must be trashed, which results in waste and lost output. To prevent...
Published: 2/13/2025   |   Inventor(s): Feng Ju, Feifan Wang
Keywords(s): Algorithm Development, Machine Learning, Manufacturing, PS-Manufacturing,Construction,Mechanical, Real-Time System
Category(s): Manufacturing/Construction/Mechanical, Physical Science, Computing & Information Technology
Machine Learning Algorithm for Inferring User Activities from IoT Device Events
The ubiquitous and heterogeneous deployment of internet of things (IoT) devices in smart homes has created new opportunities to extract knowledge, awareness, and intelligence via monitoring and understanding the devices’ interactions with their environments and users. Meaningful information from network traffic of IoT devices in smart homes can...
Published: 2/13/2025   |   Inventor(s): Guoliang Xue, Yinxin Wan, Kuai Xu, Feng Wang, Xuanli Lin
Keywords(s): Algorithm Development, Internet of Things, Machine Learning, Networks, IT, Software and Communication, PS-Computing and Information Technology, PS-Wireless and Networking, Security
Category(s): Computing & Information Technology, Physical Science, Wireless & Networking
Algorithm for Inferring User Activities from IoT Network Traffic
Recently, the surge in Internet-of-things (IoT) device deployment within smart homes has led to a large need for understanding user activities through the vast data generated by these devices. While studies have explored individual device behaviors and network traffic patterns, there remains a gap in leveraging this data collectively to infer and monitor...
Published: 2/13/2025   |   Inventor(s): Guoliang Xue, Yinxin Wan, Kuai Xu, Feng Wang
Keywords(s): Algorithm Development, Internet of Things, Networks, IT, Software and Communication, PS-Computing and Information Technology, PS-Wireless and Networking, Security
Category(s): Computing & Information Technology, Physical Science, Wireless & Networking
SARS-COV-2 papain-like protease inhibitors as antivirals
Novel compounds and their use as an inhibitor for SARS-CoV-2. Invention Summary: Two oral SARS-CoV-2 antivirals are available, molnupiravir and Paxlovid. However, the limited efficacy, drug-drug interaction, and drug resistance are main challenges facing these two drugs. Additional oral antivirals with novel mechanisms of actions are clearly needed....
Published: 7/9/2025   |   Inventor(s): Jun Wang, Edward Arnold, Francesc Ruiz Figueras, Prakash Jadhav, Bin Tan, Ahmadullah Ansari, Ashima Chopra
Keywords(s): Antiviral, Small molecules
Category(s): Technology Classifications > COVID-19, Technology Classifications > Infectious Disease, Technology Classifications > Therapeutics, Technology Classifications > Healthcare & Life Sciences
Novel Main Protease Inhibitors as SARS-CoV-2 Antivirals
This technology encompasses the development of novel inhibitors for the main protease, or Mpro, of SARS-CoV-2. The main protease of SARS-CoV-2 is a validated drug target and could be key to the development of antiviral drugs against the virus. The inhibitors proposed in this technology are notable, as they are potent main protease inhibitors with high...
Published: 2/2/2024   |   Inventor(s): Jun Wang
Keywords(s):  
Category(s): Technology Classifications > Life Sciences
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