Search Results - ivan+dmochowski

6 Results Sort By:
Xenon Biosensors Improve Early Breast Cancer Detection
A nuclear magnetic resonance (NMR) based enzyme-detection system comprising xenon (129Xe) biosensors complexed with an enzyme-specific peptide substrate. Problem: In 2023, about 298,000 American women will be diagnosed with breast cancer, with an estimated 43,700 deaths. Early cancer detection in the localized stage increases the five-year relative...
Published: 10/16/2023   |   Inventor(s): Ivan Dmochowski, Qian Wei, Nicholas Kuzma, Aru Hill
Keywords(s): Bioengineering, Imaging Agents, Neurology, Oncology, Radiology, Women's Health
Category(s): Technology Classifications > Diagnostics, Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Imaging
Tunable, Caged Molecules For In Vivo and In Situ Transcriptomic Analyses
Compounds are designed to detect and characterize specific RNAs in a cell or sub-cellular compartment using light activation. Problem: Cellular RNAs provide critical information on gene expression and regulation. A variety of methods have been developed to isolate mRNA from target cells to understand gene function; however, these methods lack the...
Published: 10/16/2023   |   Inventor(s): Ivan Dmochowski, James Eberwine, Sean Yeldell, Julianne Griepenburg, Teresa Rapp, Jennifer Singh, Jai-Yoon Sul, Jae Hee Lee
Keywords(s): Bioengineering, Neurology, Small Molecule
Category(s): Technology Classifications > Diagnostics, Technology Classifications > Chemical Processes and Synthesis
Tri-functionalized cryptophane biosensors for biomolecular imaging and MRI diagnostics
Cryptophanes with high xenon affinity enable ultrasensitive detection of analytes in solution using Xe-129 NMR/MRI Technology Overview: The Dmochowski Lab has developed biosensors comprised of tri-functionalized cryptophane with high affinity for hyperpolarized 129Xe. These biosensors can be designed to detect molecular markers associated with cancer...
Published: 1/5/2024   |   Inventor(s): Ivan Dmochowski
Keywords(s):  
Category(s): Technology Classifications > Diagnostics, Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Imaging
Photo-modulation of gene expression and RNA hydrolysis through photoactivatable oligonucleotide constructs
Light-activated DNA hairpin to control RNA digestion in gene silencing with mRNA-antisense complexes Technology Overview: Gene silencing can be achieved by targeting messenger RNA (mRNA) during the transcription process. Antisense oligodeoxynucleotides can be designed to bind to a complementary mRNA sequence, where formation of the DNA-mRNA duplex...
Published: 1/5/2024   |   Inventor(s): Ivan Dmochowski
Keywords(s):  
Category(s): Technology Classifications > Diagnostics, Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Research Tools & Reagents
A genetically encoded β-lactamase reporter for ultrasensitive 129Xe NMR and MRI in mammalian cells
Hyperpolarized xenon chemical exchange saturation transfer (CEST) contrast agent for molecular imaging Problem: While genetically encoded optical reporters have enabled biomolecular imaging, the strong scattering of light by tissue is problematic. Optical reporters are limited to examining single cells and transparent model organisms. Alternate non-invasive...
Published: 1/5/2024   |   Inventor(s): Ivan Dmochowski
Keywords(s): Imaging Agents, Radiology
Category(s): Technology Classifications > Diagnostics, Technology Classifications > Research Tools & Reagents, Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Imaging
Ruthenium photolinkers for manipulating molecular structure and function in materials science and biology
New paradigm for caging and photoreleasing polymeric systems with visible light responsive ruthenium photolinkers. Problem: Photochemical methods can manipulate and regulate molecular structure, function, and localization. Site-specifically incorporating a photolabile moiety within an oligonucleotide has remained a synthetic challenge. Moreover,...
Published: 1/5/2024   |   Inventor(s): Ivan Dmochowski
Keywords(s):  
Category(s): Technology Classifications > Research Tools & Reagents, Technology Classifications > Chemical Processes and Synthesis, Technology Classifications > Imaging, Technology Classifications > Materials