Search Results - hyun-jin+kim

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Inhibition of T Cell Differentiation and Senescence by Overexpression of Transcription Factor c-Myb
Abstract: Adoptive Cell Therapy (ACT) is a promising technique that uses a patient's own T cells to treat cancer. The process requires removing and engineering a patient's T cells to express a chimeric antigen receptor (CAR) or T cell receptor (TCR) that targets a specific cancer antigen. When the modified T cells are reintroduced into the patient,...
Published: 4/8/2024   |   Inventor(s): Sanjivan Gautam, Yun Ji, Luca Gattinoni
Keywords(s): act, Adoptive Cell Transfer, CANCER, CAR, chimeric antigen receptor, Gattinoni, Immunotherapy, Infectious Disease, Stem Cell, T cell, T Cell Receptor, TCR
Category(s): Collaboration Sought > Collaboration, Application > Therapeutics, TherapeuticArea > Oncology, Collaboration Sought > Licensing
Overexpression of Phf19 on T Cells Enhances Therapeutic Effects of T Cell-Based Therapies (such as Chimeric Antigen Receptor [CAR] Therapies)
Abstract: T cell-based immunotherapy (such as CAR therapies) is a promising approach for the treatment of several cancers. However, T cells currently employed for various T cell-based immunotherapies are usually senescent and terminally differentiated leading to poor proliferative and survival capacity, limiting their therapeutic effectiveness once...
Published: 4/8/2024   |   Inventor(s): Yun Ji, Luca Gattinoni
Keywords(s): CAR-T Therapy, CD8, chimeric antigen receptor, Gattinoni, Phf19, T cell
Category(s): TherapeuticArea > Oncology, Collaboration Sought > Licensing, Collaboration Sought > Collaboration, Application > Therapeutics
Nandrolone 17 Beta-Carbonates
Abstract: The available options for male contraceptives are limited. Androgens are administered as part of hormone-based male contraception and have also been used in the treatment of hypogonadism and hormone replacement therapy HRT. Many synthetic androgens require an oil-based delivery vehicle and have limited durations of action. This technology...
Published: 7/1/2024   |   Inventor(s): Richard Blye, Hyun Kim, Min Lee
Keywords(s): 19-nortestosterone, Androgenic Compounds, Blye, Male Contraceptive, Nandrolone, National Institute of Child Health and Human Development, NICHD
Category(s): TherapeuticArea > Endocrinology, Collaboration Sought > Licensing, Application > Therapeutics, Collaboration Sought > Collaboration, TherapeuticArea > Reproductive Health
Cell-free RNA biomarkers capable of distinguishing cancer from premalignant disease
Summary Early cancer detection is critical for improving long-term patient survival and highlights a need for new sensitive and minimally-invasive early detection methods. The current technology includes novel sets of cell-free RNA biomarkers that can be used to potentially distinguish between malignant and pre-malignant forms of certain cancers using...
Published: 6/15/2022   |   Inventor(s): Thuy Ngo, Hyun Kim, Josiah Wagner, Breeshey Roskams-Hieter, Pavana Anur
Keywords(s): Diagnostics, Diagnostics - Cancer
Category(s): Diagnostics
Research Tool: Stable reporter system for promoter activity in Listeria monocytogenes
Stable reporter system for promoter activity in Listeria monocytogenes
Published: 4/2/2020   |   Inventor(s): Abraham Sonenshein, Hyun-Jin Kim
Keywords(s):  
Category(s): Research tool: expression system