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RNA-aptamer-mediated Bacteriophage Purification
A more productive, less expensive method for purifying nanoscale biological entities such as bacteriophages, viruses, virus-like particles (VLPs), and ribosomes. Background: Working with nanometer-sized biological entities, such as viruses, virus-derivatives, and super-molecular assemblies, typically requires a purification step. Currently, this...
Published: 10/24/2025   |   Inventor(s): Ing-Nang Wang, Hua Shi, Jia Sheng, Alan Chen
Keywords(s): bacteriophage purification, phage purification, phage therapy, RNA aptamer, Technologies
Category(s): Campus > University at Albany, Technology Classifications > Biological Materials, Technology Classifications > Biomedical Science and Engineering, Technology Classifications > Healthcare, Technology Classifications > Research Tools and Reagents, Technology Classifications > Therapeutics and Vaccines
Rechargeable battery electrolytes for extreme cycling conditions
Background As the world increasingly relies on portable electronics, electric vehicles, and renewable energy storage, the demand for high-performance, reliable, and durable rechargeable batteries continues to grow. However, current lithium-ion batteries (LIBs) face significant challenges under extreme operating condi­tions, such as subzero temperatures,...
Published: 10/6/2025   |   Inventor(s): Arumugam Manthiram, Zehao Cui, Chen Liu
Keywords(s):  
Category(s): Physical sciences > Energy > Battery or electrochemical
CBLs as a biomarker of and target to treat systemic lupus erythematosus (SLE)
SLE DIAGNOSTIC TOOL CBL protein levels used as a molecular diagnostic marker to diagnose and assess severity of Systemic Lupus Erythematosus (SLE) Systemic Lupus Erythematosus patient (photo: NCRD) UNMET NEED Systemic Lupus Erythematosus (SLE) is an autoimmune disease, especially prevalent in women, and without curative treatment. In addition,...
Published: 9/11/2025   |   Inventor(s): Xin Li, Zhe-Xiong Lian, Hua Gu
Keywords(s): Innovation
Category(s): Applications > Soins et santé > Diagnostic, English Applications > Health and care > Diagnostic-ENG, Secteurs > Sciences de la vie, Sectors > Life sciences, Objectifs de Développement Durable > ODD 03 : Bonne santé et bien-être, Sustainable Development Goals > Goal 03: Good Health and Well-Being
M4 Foldamer Peptidomimetic: Targeting Amyloid-beta (Aβ) Aggregation to Restore Neuronal Function in Alzheimer’s Disease
Adantages Enhanced Blood-Brain Barrier (BBB) Penetration allows for efficient therapeutic targeting Superior serum stability enables a longer therapeutic window compared to conventional peptide therapeutics Multimodal therapeutic mechanism simultaneously addresses multiple pathological hallmarks of Alzheimer’s Disease (AD) Summary Alzheimer’s...
Published: 10/16/2025   |   Inventor(s): Jianfeng Cai, Heng Liu, Donghui Zhu, Firoz Akhter
Keywords(s): Alzheimer's Disease, Neurodegenerative Diseases, Therapeutics
Category(s): zzNeurodegenerative Diseases Treatment, Technology Classifications > Medical > Neuroscience, Technology Classifications > Medical > Therapeutics
A method for approximate searching very large files using Pigeonhole Principle
Big Data is the new term for the exponential growth of data in the Internet and traditional methods for searching large datasets with fuzzy criteria often rely on brute-force techniques, which can be inefficient and time-consuming. These approaches typically involve sequentially scanning through data, leading to performance bottlenecks, especially...
Published: 9/12/2025   |   Inventor(s): Maryam Yammahi, Simon (Semyon) Berkovich, Chen Shen
Keywords(s):  
Category(s): Technology Classifications > Therapeutics, Technology Classifications > Computers Electronics & Software > Cloud Computing, Technology Classifications > Computers Electronics & Software > Databases
AdaPipe: Adaptive Pipelines for Smart Manufacturing
THE CHALLENGE In modern industrial cyber-physical systems, the challenge lies in efficiently selecting the right data-processing pipelines to handle ever-changing manufacturing conditions, diverse datasets, and time-sensitive demands. As manufacturers increasingly rely on real-time analytics for monitoring, prediction, and control, the sheer number...
Published: 7/15/2025   |   Inventor(s): Ran Jin, Chen Xiaoyu
Keywords(s):  
Category(s): Technology Classifications > Software
LORI: Local Low-Rank Imputation for Context-Aware AI
THE CHALLENGE Leveraging Artificial Intelligence (AI) for data-driven decision-making faces a major challenge in automatically configuring and optimizing complex AI pipelines across different use cases. As organizations deal with diverse datasets and fast-changing requirements, selecting the right combination of processing steps becomes increasingly...
Published: 10/17/2025   |   Inventor(s): Ran Jin, Chen Xiaoyu
Keywords(s):  
Category(s): Technology Classifications > Software
Attention-on-Attention for Human-Guided AI
THE CHALLENGE A major challenge facing industries like advanced manufacturing and quality inspection is the gap between human expertise in visual search and the limited capabilities of current AI systems. While skilled inspectors can dynamically scan, interpret, and integrate subtle visual cues over time, most existing automated solutions rely on static...
Published: 10/17/2025   |   Inventor(s): Ran Jin, Chen Xiaoyu
Keywords(s):  
Category(s): Technology Classifications > Communication, Technology Classifications > Software
Sensitive Point-of-Care miRNA Detection Using a One-Pot, Isothermal Assay
Rapid, RNA Extraction-Free Detection of miRNAs Biomarkers for Accurate Cancer Diagnosis and Prognosis This CRISPR-Cas12a-based assay allows for the rapid, sensitive detection of microRNAs using a one-pot, isothermal process. MicroRNAs(miRNAs) are endogenous and short, non-coding single-stranded RNAs. They participate in various biological functions...
Published: 5/30/2025   |   Inventor(s): Yong Zeng, He Yan
Keywords(s):  
Category(s): Technology Classifications > Human Health Care > Diagnostics, Technology Classifications > Veterinary > Diagnostics
Anti-Thrombin Nanoparticles and Therapeutics to Treat Necrotizing Enterocolitis
Advantages: Bivalirudin-tagged nanoparticles bind and neutralize nascent thrombin in clots, minimizing systemic anticoagulant effects Anti-thrombin nanoparticle confines its anticoagulant activity to sites of clot formation, limiting excessive systemic coagulation inhibition Dual therapeutic and diagnostic potential allows clinicians to treat NEC...
Published: 2/5/2025   |   Inventor(s): Akhil Maheshwari, Samuel Wickline, Koppenruncholan Namachivayam, Hua Pan
Keywords(s): Gastrointestinal / Digestive Health, Pharmaceuticals
Category(s): Technology Classifications > Medical > Pharmaceuticals
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