Search Results - high-throughput+screen

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Cotranslational Protein Expression System for High-throughput Screening
Reporter gene-based assays are used extensively in high-throughput screening (HTS) to identify chemical modulators of cellular pathways for drug discovery and development. However, such screening frequently results in a large number of false “hits” due to interactions of screened compounds with reporter proteins, producing confounding results. Thus,...
Published: 10/28/2024   |   Inventor(s): Chih-Chien (Ken) Cheng, Samuel Hasson, James Inglese
Keywords(s): AC4XXX, ACXXXX, AXXXXX, Coincidence, drug discovery, Drug Screening, High-throughput, High-throughput screen, HTS, REPORTER, reporter gene
Category(s): Collaboration Sought > Collaboration
Inhibitors of Glucose Kinases: Update 2-27-2019
Reference #: 01401 The University of South Carolina is offering licensing opportunities for Monosaccharide Amine and 3-Nitro-2-Phenyl-2H-Chromene Based Inhibitors of Glucose Kinases Background: When a kissing bug bites a human, they can be infected with a Kinetoplastid parasite such as Trypanosoma cruzi (T. cruzi). A need exists for new drugs that...
Published: 9/4/2022   |   Inventor(s): Edward D'antonio
Keywords(s): African Sleeping Sickness, Chagas' Disease, drug discovery, Glucokinase, Glucose Kinases, Glycolysis, Hexokinase, High-Throughput Screen, HTS, inhibitor, Inhibitor constant (Ki), Leishmanisis, Parasite, Parasitic Infections, Pentose Phosphate Pathway, Trypanosoma brucei, Trypanosoma cruzi, Trypanosome
Category(s): Chemistry and Biochemistry, Biomedical and Life Sciences