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In normal differentiated cells, most of the genome is densely methylated, except CpG islands near promoters of actively transcribed genes. Maintaining this boundary between unmethylated promoter-associated and adjacent methylated regions is crucial as loss of segregation can lead to disease. Unfortunately, it is not clear where these boundaries are,...

Published: 6/5/2024 | Inventor(s): Li Liu, Jingmin Shu

Keywords(s):

Category(s): Applied Technologies, Genomic Assays/Reagents/Tools, Life Science (All LS Techs), Diagnostic Assays/Devices

Peptide Mimetic Ligands of Polo-like Kinase 1 Polo Box Domain (“Plk1 PBD Portfolio”)

Abstract: Polo-like kinase 1 (Plk1) is a critical protein involved in regulation of mitosis, and aberrant expression of this kinase is found in various cancer types. Inhibition of Plk1 is currently being pursued in pre-clinical drug development for novel anti-cancer therapeutics. Plk1 contains an allosteric domain, known as the polo-box domain (PBD),...

Published: 5/22/2024 | Inventor(s): Terrence Burke, Jung-Eun Park, Wen-Jian Qian, Fa Liu, Kyung Lee

Keywords(s): Burke, CANCER, mitosis, Peptide Inhibitor, polo-box domain (PBD), Polo-like kinase 1 (Plk1), therapeutic

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Oncology, Application > Therapeutics

PMU-Embedded Analytics for Online Event Detection and Classification in Power Grids

The energy requirement of the world is increasing exponentially every year. With the power demand sites concentrated in the region with the highest population density, energy production sites must be located remotely. This isolation requires lengthy and complicated grids to be designed and manufactured to transmit power over long distances. Grid failures...

Published: 7/30/2024 | Inventor(s): Payman Dehghanian, Shiyuan Wang, Li Li

Keywords(s):

Category(s): Technology Classifications > Industrial or Consumer Tech > Energy Infrastructure and Environment

JobViz: User Interface for Visualization of Majors & Jobs

Invention Summary: University (and industry) career search portals and web-based job search engines allow users to search on many items (e.g., education, location, level, etc.) and then present a text based list of potential job opportunities. University career portals are not as conductive to exploration by job and career searchers as they could...

Published: 9/8/2022 | Inventor(s): Deborah Silver, Li Liu

Keywords(s):

Category(s): Technology Classifications > Software & Copyright, Technology Classifications > Software & Algorithms

Monolithic White and Multi-Color Lasers Tunable in Full Visible Spectrum

Semiconductor lasers able to emit over the full visible color spectrum have a wide range of practical applications such as solid-state lighting, full-color displays, visible color communications, and multi-color fluorescence sensing. To the human eye, light with a mixture of four monochromatic lasers is visually equivalent to a white illuminant. Current...

Published: 2/23/2023 | Inventor(s): Cun-Zheng Ning, Sunay Turkdogan, Zhicheng Liu, Fan Fan

Keywords(s): Materials and Electronics

Category(s): Advanced Materials/Nanotechnology, Chemical/Biological Sensors, Energy & Power, Imaging, Medical Imaging, Physical Science, Physics, Proteomic Assays/Reagents/Tools, Semiconductor Devices, Semiconductors, Materials & Processes

Fuel Cell With Dynamic Response Capability Based On Energy Storage Electrodes

UC Case No. 2017-231SUMMARYUCLA researchers in the Department of Chemical Engineering have developed fuel cells with energy-storage capabilities.BACKGROUNDCurrent fuel cell technologies are limited by cost and lifetime, as well as poor response to operating condition fluctuations. Adding energy storage devices to fuel cells can improve their dynamic...

Published: 7/19/2023 | Inventor(s): Yunfeng Lu, Jing Liu, Gurong Shen, Fang Liu, Haobin Wu, Jinlai Li, John Lemmon

Keywords(s): Energy & Water

Category(s): Energy & Environment > Energy Storage, Energy & Environment > Energy Storage > Fuel Cells

Distributed Feedback Fiber Laser Pumped by Multimode Diode Lasers

Researchers at the University of Arizona College of Optical Sciences and Canada's Carleton University recently succeeded in fabricating high reflectivity (>99%) Fiber Bragg Gratings (FBGs) into phosphate glass fibers using UV light and a phase mask technique. With this new manufacturing technique, fiber lasers can be created as single monolithic...

Published: 4/3/2023 | Inventor(s): Nasser Peyghambarian, Axel Schülzgen, Li Li, Jacques Albert

Keywords(s):

Category(s): Technology Classifications > Imaging & Optics, Technology Classifications > Imaging & Optics > Lasers & Other Sources

All-Fiber Multicore Fiber Laser Devices

Researchers at the University of Arizona have developed a compact, power-scalable, alignment-free fiber laser that takes a new approach to stabilizing phase-locked operation of multi-core fiber lasers by completely removing all free space optical components. This high-brightness, all-fiber laser package uses passive optical fiber spliced at both ends...

Published: 4/3/2023 | Inventor(s): Nasser Peyghambarian, Axel Schülzgen, Li Li

Keywords(s):

Category(s): Technology Classifications > Imaging & Optics, Technology Classifications > Imaging & Optics > Fiber Optics, Technology Classifications > Imaging & Optics > Lasers & Other Sources